Usplus
Also known as: Saw Palmetto, USPlus, Serenoa serrulata, Saw palmetto extract, Sabal, *Serenoa repens*
Overview
Saw Palmetto, scientifically known as *Serenoa repens*, is a plant indigenous to the southeastern United States. The lipidosterolic extract (LSE) derived from its berries is effectively utilized for alleviating symptoms associated with benign prostatic hyperplasia (BPH), particularly lower urinary tract symptoms (LUTS) like increased urinary frequency, and nocturia. The standardized extract, USPlus, is characterized by containing ≥ 80% fatty acids and is extracted through ultra-high pressure supercritical CO2 methods. Although numerous studies have been conducted, the evidence showcasing Saw Palmetto's effectiveness is mixed. Many systematic reviews and meta-analyses suggest some patients experience symptom relief while others see minimal effects. The quality of the existing evidence varies markedly, necessitating further high-quality trials to confirm efficacy and establish clearer guidelines for usage.
Benefits
Evidence supports Saw Palmetto's role in managing symptoms of BPH, particularly among men presenting with moderate LUTS. A notable systematic review indicated significant reductions in urinary symptom scores; for instance, patients taking 320 mg daily experienced a median decrease in International Prostate Symptom Score (IPSS) from 10 to 7 (p = 0.005) after 12 weeks. Other reports highlighted improvements in uroflowmetry, including enhanced maximum flow rates and reduced voiding times, particularly for patients with moderate baseline IPSS scores. The effects appear to progress over time, with notable benefits manifesting after both 6 and 12 weeks, and effect sizes suggest moderate to substantial clinical relevance.
How it works
The exact action mechanism of Saw Palmetto remains partially elucidated, although it is primarily associated with anti-androgenic effects, specifically inhibiting the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT), a hormone implicated in BPH. Additionally, anti-inflammatory effects may play a role, enhancing urinary function by improving parameters such as flow rates. The supercritical CO2 extraction method used in USPlus boosts the extract's bioavailability, potentially amplifying its effects within the body.
Side effects
Saw Palmetto is largely regarded as safe for most individuals when used appropriately; however, some common side effects include gastrointestinal discomfort (nausea, diarrhea, abdominal pain) reported in over 5% of users, as well as less frequent effects like headache and dizziness (1-5%). Rarely (<1%), serious allergic reactions and liver damage have been documented. It is important to note potential drug interactions, particularly with anticoagulant therapies and hormone treatments. Contraindications include pregnancy and breastfeeding due to insufficient safety data. Special caution is recommended for individuals with bleeding disorders or those anticipating surgical procedures, given the herb's potential effects on blood coagulation.
Dosage
The effective therapeutic range for Saw Palmetto extract generally falls between 160-320 mg per day, with 320 mg being optimal as evidenced by significant clinical outcomes observed in studies. It is recommended that the supplement be taken consistently, typically once or twice a day, with no specific timing constraints identified. Though no upper limit has been well-defined, dosage exceeding 320 mg lacks extensive research backing. The formulation of USPlus—standardized to ≥ 80% fatty acids—along with its enhanced absorption due to supercritical CO2 extraction, may offer better efficacy than non-standardized preparations.
FAQs
How long does it take to see benefits?
Most users report significant improvements within 6-12 weeks of consistent use.
Are there any interactions with other medications?
Yes, it can interact with blood thinners and hormone therapies; consult your healthcare provider.
Is it safe for long-term use?
Generally safe when used as directed; however, long-term safety data is limited.
What are the common side effects?
Gastrointestinal symptoms, headache, and dizziness are the most commonly reported side effects.
Can it be taken at any time of day?
Yes, USPlus can be taken at any time, but consistency in timing is recommended.
Research Sources
- https://www.canjurol.com/html/free-articles/2024/31-06/CJU_V31I6_07_FREE_DrWinograd.pdf – This study assessed the efficacy of Saw Palmetto extract (USPlus) in treating BPH symptoms. Results indicated significant improvement in health outcomes measured by IPSS and uroflowmetry parameters, although the study faced limitations due to its single-arm design.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/profiling-inflammatory-cytokines-following-zinc-supplementation-a-systematic-review-and-metaanalysis-of-controlled-trials/6832DB5FADF99633326AB4005C55E13F – This systematic review compared Saw Palmetto to tamsulosin, finding mixed effectiveness for BPH management, highlighting the need for further research and noting the heterogeneous quality among included studies.
- https://consumers.cochrane.org/cochrane-and-systematic-reviews – The Cochrane review collectively evaluated multiple studies on phytotherapies, including Saw Palmetto, concluding that the evidence for efficacy in alleviating BPH symptoms remains inconclusive and underscores variability in study outcomes.
Supplements Containing Usplus
Ultra Natural Prostate
Life Extension
ProstateMD
1MD
ProstateMD
1MD
Clinical Formula Hair Vitamins
Hair La Vie
ProstateMD
1MD Nutrition
Clinical Formula Hair Vitamins
Hair La Vie
Hair La Vie™ CLINICAL FORMULA - HAIR VITAMINS - RESCUE, REJUVENATE, & GROW.
Hair La Vie™