Vasodilase
Also known as: Vasodilase, Vasodilase (Proprietary Blend)
Overview
Vasodilase appears to be a proprietary or commercial name for a supplement blend, rather than a single chemical or botanical entity. No direct peer-reviewed data on "Vasodilase" as a distinct supplement ingredient or formulation was found in scientific databases. By inference, based on its name, it is designed as a vasodilatory supplement, likely containing ingredients that promote blood vessel dilation and improve vascular function. Common vasodilatory agents often found in such blends include alpha-lipoic acid (ALA), folic acid, and magnesium, all of which have been extensively studied for their cardiovascular benefits. These types of supplements typically aim to improve blood flow, reduce blood pressure, and enhance endothelial function by improving the lining of blood vessels, reducing arterial stiffness, or directly lowering blood pressure. While there are no direct randomized controlled trials (RCTs) or meta-analyses on "Vasodilase" specifically, related compounds commonly associated with vasodilation have moderate to high-quality evidence supporting their vascular benefits.
Benefits
Since no direct evidence on "Vasodilase" was found, the benefits are inferred from key vasodilatory agents commonly found in such supplements. Alpha-lipoic acid (ALA) has been shown to reduce both systolic and diastolic blood pressure. A meta-analysis of 11 RCTs involving 674 patients found ALA supplementation reduced SBP by approximately 5.46 mmHg and DBP by 3.36 mmHg over up to 12 weeks, with moderate evidence due to potential publication bias. Folic acid significantly improves endothelial function, specifically flow-mediated dilation (FMD), which is crucial for vascular health. A systematic review and dose-response meta-analysis indicated a significant increase in FMD and FMD% in adults with cardiovascular risk factors, showing a clear dose-response relationship. Magnesium supplementation, particularly long-term (≥6 months), has been shown to improve endothelial function, especially in individuals with pre-existing health conditions. A systematic review and meta-analysis highlighted its benefits in improving vascular health.
How it works
The presumed mechanism of action for "Vasodilase" is based on the known effects of common vasodilatory ingredients it likely contains. Alpha-lipoic acid (ALA) functions as a potent antioxidant, which helps reduce oxidative stress and enhances the bioavailability of nitric oxide (NO). Increased NO leads to vasodilation, thereby lowering blood pressure. Folic acid improves endothelial function by increasing the production of nitric oxide and reducing homocysteine levels, a compound that can impair vascular health, thus promoting better vascular dilation. Magnesium acts as a natural calcium antagonist, which means it helps relax the smooth muscle cells in blood vessel walls, leading to vasodilation and improved endothelial function.
Side effects
As there is no direct safety data available for "Vasodilase" itself, the safety profile is based on its likely constituent ingredients: alpha-lipoic acid (ALA), folic acid, and magnesium. These individual agents are generally considered safe when taken at recommended doses, with a low incidence of adverse effects. The most commonly reported side effects for these supplements are mild gastrointestinal symptoms, such as nausea, stomach upset, or diarrhea. These effects are typically transient and resolve with continued use or dose adjustment. No significant drug interactions have been consistently reported in the meta-analyses and systematic reviews for ALA, folic acid, or magnesium at typical supplemental doses. However, individuals on specific medications, such as blood thinners or certain heart medications, should consult a healthcare professional before taking any vasodilatory supplements. Pregnant or breastfeeding women and individuals with pre-existing medical conditions should also seek medical advice prior to use. There are no specific contraindications identified for a blend like "Vasodilase" beyond those for its individual components.
Dosage
Without specific information on the formulation of "Vasodilase," dosage guidelines are based on its likely active ingredients. For Alpha-Lipoic Acid (ALA), effective doses for blood pressure reduction are typically less than 800 mg per day, with benefits observed for up to 12 weeks. For Folic Acid, benefits on endothelial function are seen with typical supplementation doses, often ranging from 400 to 800 mcg per day, with a clear dose-response relationship. For Magnesium, improvements in endothelial function are generally observed with supplementation lasting at least 6 months, with common daily doses ranging from 200 to 400 mg of elemental magnesium. It is important to note that the specific dosage for "Vasodilase" would depend on the concentration and combination of these ingredients within the proprietary blend. Users should always follow the manufacturer's recommended dosage on the product label and consult with a healthcare professional for personalized advice, especially if they have underlying health conditions or are taking other medications.
FAQs
What is Vasodilase?
Vasodilase appears to be a proprietary supplement blend, not a single ingredient. It is likely formulated to promote vasodilation and improve blood flow, possibly containing ingredients like alpha-lipoic acid, folic acid, and magnesium.
Are there any direct studies on Vasodilase?
No direct peer-reviewed studies or clinical trials on 'Vasodilase' as a specific product were found. Research on its potential benefits is inferred from studies on its likely individual components.
How long does it take to see benefits from vasodilatory supplements?
Benefits from vasodilatory supplements, such as those containing ALA, folic acid, or magnesium, typically require weeks to months of consistent supplementation to manifest, with some studies showing effects after 12 weeks or even 6 months.
Are there any side effects of Vasodilase?
Based on its likely ingredients, Vasodilase is generally considered safe at recommended doses. Mild gastrointestinal upset is the most common side effect for its potential components like ALA, folic acid, and magnesium.
Research Sources
- https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1272837/full – This meta-analysis of 11 RCTs (674 patients, ≤12 weeks) found that alpha-lipoic acid supplementation significantly reduced systolic blood pressure by 5.46 mmHg and diastolic blood pressure by 3.36 mmHg. The study provides moderate evidence for SBP reduction, noting potential publication bias and short duration as limitations.
- https://pubmed.ncbi.nlm.nih.gov/36829207/ – This systematic review and dose-response meta-analysis demonstrated that folic acid supplementation significantly improved endothelial function, as measured by flow-mediated dilation (FMD). The study highlighted a clear dose-response relationship and included multiple RCTs, indicating high quality evidence for its vascular benefits.
- https://pubmed.ncbi.nlm.nih.gov/31845310/ – This systematic review and meta-analysis concluded that oral magnesium supplementation improved endothelial function, particularly in unhealthy subjects, after at least 6 months of use. The study suggests that longer duration and variable doses are factors to consider, providing moderate evidence for magnesium's role in vascular health.
