Vazguard
Also known as: Bergamot Phytosome, Citrus bergamia, Bergamot Extract, Bergamot Oil, Bergamot (Citrus bergamia) Polyphenols
Overview
Bergamot is a citrus fruit recognized for its fragrant and flavorful peel, from which polyphenols are extracted for health benefits. These polyphenols are formulated into phytosomes, complexes with phospholipids that enhance their bioavailability. Primarily, bergamot polyphenols are utilized to manage dyslipidemia, reduce visceral adipose tissue (VAT), and improve metabolic profiles. The formulation's improved absorption capabilities have been backed by a range of studies, with research maturity indicating a solid body of evidence, including several clinical trials and systematic reviews demonstrating significant effects on cholesterol levels and body composition.
Benefits
The evidence-based benefits of bergamot phytosomes include reductions in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and an increase in high-density lipoprotein cholesterol (HDL-C). A systematic review indicates TC can be decreased by 12.3% to 31.3%, LDL-C by 7.6% to 40.8%, and TG by 11.5% to 39.5%. Further studies show improvements in VAT and lipid profiles, particularly in overweight and obese individuals with mild hypercholesterolemia, with beneficial effects observable as early as 30 days post-supplementation. In addition, antioxidant and anti-inflammatory effects have been noted, contributing to cardiovascular health.
How it works
Bergamot polyphenols function primarily by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), which plays a critical role in cholesterol synthesis. The phytosome formulation significantly enhances the bioavailability of these polyphenols, thereby improving their absorption. These compounds modulate lipid metabolism, reduce oxidative stress, and mitigate inflammation, collectively benefiting cardiovascular health.
Side effects
Bergamot phytosomes are generally well-tolerated, with no significant adverse effects reported in the literature. There are no common side effects (>5%) or rare side effects (<1%) noted. While no specific drug interactions are documented, it's advised to monitor lipid profiles when used alongside statins due to potential enhanced efficacy. Additionally, no contraindications have been identified, making it safe for use among overweight and obese individuals with mild hypercholesterolemia, although caution is recommended in populations not specifically studied.
Dosage
The minimum effective dosage for bergamot phytosome is typically 500 mg per day, standardized to contain 11-19% total flavanones. The optimal dosage is around 500 mg daily, often divided into two tablets of 250 mg each. No maximum safe dosage has been established, but higher doses have not been extensively studied. While there are no specific timing recommendations for taking the supplement, divided doses may enhance absorption and overall compliance. The phytosome formulation is key to enhancing bioavailability compared to pure extracts.
FAQs
Is bergamot phytosome safe?
Yes, bergamot phytosomes are generally safe with no significant adverse effects reported during studies.
When should I take bergamot phytosome?
It can be taken at any time; however, divided doses may improve absorption.
How soon can I expect results?
Significant improvements in lipid profiles and VAT can be observed within 30 days of supplementation.
Can I replace my statin with bergamot?
No, it should not replace statins but may be used as an adjunct therapy.
Research Sources
- https://www.mdpi.com/1422-0067/25/8/4162 – This systematic review consolidates findings from twelve studies demonstrating that bergamot supplementation significantly decreases TC, LDL-C, and TG while increasing HDL-C, with reductions ranging notably across measures.
- https://pubmed.ncbi.nlm.nih.gov/32417999/ – A randomized, placebo-controlled trial involving 64 overweight and obese individuals found that bergamot phytosome significantly reduced VAT, TC, and LDL-C after 30 days of daily supplementation, confirming its efficacy in lipid regulation.
- https://pubmed.ncbi.nlm.nih.gov/31670973/ – This preclinical study on Wistar rats demonstrated that the phytosome formulation of bergamot significantly improved lipid profiles compared to pure extract, indicating superior metabolic regulatory effects.
