Verbascoside Verbasnol
Also known as: Acteoside, VerbasnolTM, Verbascoside
Overview
Verbascoside, also known as acteoside, is a phenylpropanoid glycoside with the chemical formula C29H36O15 and CAS number 61276-17-3. It is a naturally occurring compound found in various plants, including *Rehmannia glutinosa*, and is recognized for its antioxidant properties. Verbascoside is commonly utilized in topical and oral supplements due to its potential anti-inflammatory, anti-aging, and skin-protective benefits. It exhibits strong antioxidant capabilities, with mechanisms including the inhibition of enzymes like tyrosinase and collagenase, which play roles in skin pigmentation and aging. While there is some preliminary evidence supporting its beneficial effects, particularly in skincare, more comprehensive clinical research is necessary to validate efficacy and safety for various applications.
Benefits
Research indicates that verbascoside may help inhibit tyrosinase, which could lead to skin lightening, and reduce collagenase activity, potentially promoting youthful skin. It is particularly noted for its antioxidant and anti-inflammatory effects, which may benefit individuals with conditions such as acne or those seeking overall skin health improvements. However, quantified outcomes in human studies remain limited, and the clinical significance of these effects requires further validation through randomized clinical trials.
How it works
Verbascoside functions primarily as an antioxidant, exhibiting its effects by inhibiting the activity of enzymes like tyrosinase and collagenase. It also appears to modulate inflammatory responses by influencing pro-inflammatory chemokines such as IL-8. Additionally, verbascoside may promote healthy skin and potentially influence hair follicle health by inhibiting 5α-reductase, thus contributing to its multifaceted benefits for skin and hair.
Side effects
Verbascoside is generally considered safe for topical applications; however, safety data regarding oral consumption is limited. No significant side effects have been documented in the available literature, with reports largely absent. Potential drug interactions have not been extensively studied, and while there are no specified contraindications, caution is recommended due to the lack of comprehensive safety data. Pregnant and breastfeeding women should consult healthcare providers prior to use, as specific safety profiles for these populations are not established.
Dosage
For topical use, a concentration of 0.5-1% of verbascoside is recommended to achieve desired effects. For oral supplementation, a suggested dosage is 10 mg, although both efficacy and safety at this dosing level remain inadequately substantiated. There are no defined optimal dosage ranges or maximum safe doses specified in the literature, nor are there established timing considerations for either form of administration. Verbascoside is available in both topical and oral forms, but details on absorption and bioavailability in humans are scarce.
FAQs
Is verbascoside safe to use?
Generally, verbascoside is considered safe for topical applications, but comprehensive safety data for oral use is lacking.
What benefits can I expect from using verbascoside?
Potential benefits include improved skin health and anti-aging effects, although human studies documenting these effects are limited.
How should I apply verbascoside?
For topical use, apply products with a concentration of 0.5-1%. For oral supplements, a typical dosage is about 10 mg.
Are there any known side effects?
Documented side effects are minimal, and no significant adverse effects have been reported in the current literature.
Can pregnant or breastfeeding women use verbascoside?
It is advisable for pregnant or breastfeeding women to consult their healthcare providers before using verbascoside due to limited safety data.
Research Sources
- https://magistralbr.caldic.com/storage/product-files/1116208663.pdf – This source discusses the properties and applications of verbascoside, emphasizing its antioxidant and anti-inflammatory effects, particularly in skincare.
- https://nulivscience.com/ingredients/verbasnol/ – Nuliv Science provides insights into VerbasnolTM, highlighting its use as a beneficial ingredient in various formulations due to its skin-protective properties.
- https://www.mdpi.com/2076-3921/13/9/1040 – This study published in MDPI outlines the mechanisms underlying verbascoside's biological effects, focusing on its antioxidant capabilities and skin health benefits.
- https://www.vitalproteins.com/pages/ingredient-verbascoside-verbasnol – Vital Proteins outlines the benefits and applications of verbascoside, focusing on its role in enhancing skin health and its potential anti-aging effects.
