Vineatrol 20 Grapevine Extract
Also known as: Vineatrol 20, Grapevine shoot extract, Grapevine cane extract, Vitis vinifera extract, Resveratrol extract, Stilbenoid-rich extract, Vineatrol 20 Grapevine Extract
Overview
Vineatrol 20 is a branded extract derived from grapevine shoots (*Vitis vinifera*), standardized to contain a minimum of 5% trans-resveratrol, 5% trans-ε-viniferin, and a total of 20% resveratrol monomers and oligomers. It is marketed as a polyphenol antioxidant supplement, primarily for cardiovascular health support, antioxidant effects, and potential calorie restriction mimetic properties. The active components, including trans-resveratrol and trans-ε-viniferin, are stilbenoids, a class of polyphenolic compounds. Research on Vineatrol 20 is emerging, with preclinical and some clinical data suggesting potential benefits. It is considered to have moderate research maturity, with evidence including animal studies demonstrating cardioprotective effects and some human trials on grape-derived polyphenols. However, direct, high-quality randomized controlled trials (RCTs) specifically on Vineatrol 20 are limited.
Benefits
Vineatrol 20 exhibits several potential benefits, primarily related to cardiovascular health and antioxidant activity. Animal studies have demonstrated cardioprotective effects, including improved plasma lipid profiles, reduced cardiac tissue necrosis, and enhanced antioxidant defenses, suggesting reduced oxidative stress and improved heart function. The extract also shows angiotensin-converting enzyme (ACE) inhibitory activity, potentially lowering blood pressure and reducing cardiovascular risk. The stilbenoid content contributes to antioxidant and anti-inflammatory properties, reducing lipid peroxidation and DNA damage in cardiac tissue. Secondary benefits may include improved lipid metabolism and reduced oxidative stress markers. Individuals at risk of heart disease may benefit most from these effects. While effect sizes are well-demonstrated in animal models, human clinical data specific to Vineatrol 20 are limited.
How it works
Vineatrol 20's mechanism of action involves several biological pathways. Its antioxidant activity reduces reactive oxygen species and lipid peroxidation, while it also upregulates endogenous antioxidant enzymes like glutathione peroxidase. The extract's ACE inhibition leads to vasodilation and blood pressure reduction. It also modulates inflammatory pathways and cellular stress responses. The primary interaction is with the cardiovascular system, affecting the heart and blood vessels, with systemic antioxidant effects. Molecular targets include the ACE enzyme, oxidative stress pathways, mitochondrial function, and possibly sirtuins, which are related to calorie restriction mimetics. Resveratrol and its oligomers have limited bioavailability due to rapid metabolism, but standardization aims to optimize bioactive content.
Side effects
Vineatrol 20 is generally considered safe at typical supplement doses, with resveratrol-containing extracts having a good safety profile in clinical studies. Common side effects, occurring in more than 5% of users, include mild gastrointestinal discomfort reported with high doses of resveratrol supplements. Uncommon side effects, affecting 1-5% of users, may include headache or dizziness. Rare side effects, affecting less than 1% of users, include allergic reactions. Potential drug interactions exist with anticoagulants or antihypertensive drugs due to blood-thinning and blood pressure-lowering effects. It is contraindicated in pregnancy, breastfeeding, and in patients on blood thinners. Limited data are available for children and pregnant women, so caution is advised.
Dosage
No specific dose has been established for Vineatrol 20. Resveratrol studies often use 100–500 mg/day. Vineatrol 20 is standardized to deliver at least 5% trans-resveratrol and 20% total resveratrols; typical supplement doses would be adjusted to provide effective stilbenoid amounts, often in the range of 50–200 mg total stilbenoids daily. Up to 1 g/day of resveratrol has been used safely in clinical trials, but long-term safety at high doses is unclear. It may be taken with meals to improve absorption and reduce gastrointestinal side effects. Extracts standardized for stilbenoid content are preferred. Bioavailability may be enhanced by formulation with lipids or other bioenhancers. No specific cofactors are required, but antioxidants like vitamin C may have synergistic effects.
FAQs
Is Vineatrol 20 just resveratrol?
No, it contains a mix of resveratrol monomers and oligomers, including trans-ε-viniferin, which may have distinct biological effects.
Is more resveratrol better?
Resveratrol acts hormetically; low to moderate doses promote beneficial stress responses, but very high doses may not be advantageous long-term.
How quickly do benefits appear?
Cardiovascular and antioxidant effects may require weeks of consistent use.
Is it safe long-term?
Generally yes, but long-term human data specific to Vineatrol 20 are limited.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/38231829/ – An animal study using a myocardial injury model found that a grape shoot extract rich in trans-resveratrol and trans-ε-viniferin improved lipid profiles, reduced cardiac necrosis, and enhanced antioxidant enzymes. The extract also demonstrated ACE-inhibitory activity, suggesting potential cardioprotective benefits. This study provides preclinical evidence supporting the use of grapevine extracts for cardiovascular health.
- https://www.qualialife.com/formulation/vineatrol-20-grapevine-extract – This source provides information on the formulation of Vineatrol-20 and its intended use as a supplement. It highlights the standardization of the extract for resveratrol monomers and oligomers, emphasizing its potential benefits for cardiovascular health and antioxidant support. While not a primary research article, it offers context on the product's composition and intended applications.
- https://oeno-one.eu/article/view/3453 – This study focuses on chemical processes to enhance oligostilbene content in grapevine extracts. The findings suggest that increasing oligostilbene content may improve biological efficacy, which supports the rationale for Vineatrol 20’s oligomer content. Although it lacks clinical data, it provides valuable insights into optimizing the composition of grapevine extracts for potential health benefits.
- https://www.mdpi.com/2304-8158/12/23/4351 – This article discusses the potential health benefits of grapevine extracts, particularly focusing on their antioxidant and anti-inflammatory properties. It highlights the role of stilbenoids, including resveratrol, in reducing oxidative stress and inflammation, which are key factors in various chronic diseases. The review supports the use of grapevine extracts as a natural source of bioactive compounds with potential therapeutic applications.
- https://medlineplus.gov/druginfo/natural/472.html – This MedlinePlus entry provides general information about resveratrol, including its uses, potential benefits, and safety considerations. It notes that resveratrol has been studied for its antioxidant and anti-inflammatory effects, as well as its potential to improve cardiovascular health. The entry also includes information on dosage and potential side effects, offering a comprehensive overview of resveratrol as a natural supplement.