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Walnut Leaf Glycerite Liquid Extract

Also known as: Walnut leaf extract, Walnut leaf glycerite liquid extract, Juglans regia, Juglans regia L. leaf extract

Overview

Walnut leaf glycerite liquid extract is a botanical supplement derived from the leaves of the Juglans regia L. tree. It is typically prepared as a hydroalcoholic or glycerite extract, rich in bioactive compounds such as polyphenols, flavonoids, juglone, and ellagitannins. Traditionally recognized for its antioxidant and anti-inflammatory properties, recent research has primarily focused on its potential role in managing type 2 diabetes mellitus (T2DM) and its effects on glycemic control. Studies, including randomized controlled trials and meta-analyses, indicate its ability to significantly reduce fasting blood glucose and improve insulin levels in T2DM patients. While it shows promise for glycemic management, it does not appear to significantly impact lipid profiles.

Benefits

The primary benefit of walnut leaf extract is its ability to improve glycemic control in individuals with type 2 diabetes mellitus. A meta-analysis of four randomized controlled trials involving 195 subjects demonstrated a significant reduction in fasting blood glucose (weighted mean difference approximately -18 mg/dL) and an increase in fasting insulin levels (WMD ~1.93 U/L), suggesting enhanced insulin secretion or sensitivity. For long-term glycemic control, a reduction in HbA1c (WMD ~ -0.64%) was observed in studies lasting longer than 8 weeks. These effects are particularly relevant for adults with T2DM. While showing moderate effects on glucose and insulin, no significant improvements in lipid profile parameters (total cholesterol, LDL, HDL, triglycerides) have been consistently found. The evidence for glycemic benefits is considered moderate to strong, based on high-quality meta-analyses of RCTs.

How it works

Walnut leaf extract exerts its effects primarily through its rich content of polyphenols and juglone, which possess antioxidant and anti-inflammatory properties. The proposed mechanisms of action include the enhancement of insulin secretion from pancreatic beta cells and an improvement in insulin sensitivity in peripheral tissues. These actions contribute to better glucose uptake and utilization by the body. The antioxidant activity of the extract may also play a role by reducing oxidative stress, which is often implicated in the progression and complications of diabetes. The bioactive compounds are thought to modulate various glucose metabolism pathways, leading to improved glycemic control.

Side effects

Walnut leaf extract appears to have a favorable safety profile, with clinical trials reporting no significant adverse effects. Common side effects, if any, are generally considered mild and are not well-documented in the current research. There are no significant drug interactions or contraindications specifically reported in the analyzed studies. However, comprehensive data on drug interactions are limited, and caution is advised. Specific safety data for vulnerable populations such as pregnant or lactating women and children are insufficient, and therefore, its use in these groups is not recommended without further research. As with any supplement, individuals with pre-existing medical conditions or those taking medications should consult a healthcare professional before use.

Dosage

Clinical trials investigating walnut leaf extract for glycemic control have typically used doses ranging from 100 mg/day, often increasing to 200 mg/day. The optimal dosage for achieving glycemic benefits appears to be around 200 mg/day of a hydroalcoholic leaf extract. For effects on HbA1c, supplementation for at least 8 weeks is recommended, as shorter durations may not show significant long-term glycemic improvements. The extract should be taken daily. There is currently no established maximum safe dose from the available clinical data, but doses used in trials were generally well tolerated. Specific timing of administration (e.g., with meals) is not consistently reported but daily intake is key.

FAQs

Is walnut leaf glycerite effective for diabetes?

Yes, evidence from clinical trials and meta-analyses suggests it can modestly improve glycemic control, particularly by reducing fasting blood glucose and HbA1c in type 2 diabetes patients.

Is walnut leaf glycerite safe?

It appears generally safe, with no significant adverse effects reported in clinical studies. However, data for pregnant/lactating women and children are insufficient.

How long until effects appear?

Improvements in fasting glucose may be seen sooner, but significant reductions in HbA1c typically require at least 8 weeks of consistent supplementation.

Does it improve cholesterol?

Current research indicates that walnut leaf extract does not significantly improve lipid profile parameters such as total cholesterol, LDL, HDL, or triglycerides.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9065396/ – This meta-analysis of randomized controlled trials (RCTs) investigated the effect of Juglans regia L. leaf extract on glycemic control in type 2 diabetes. It found significant reductions in fasting blood glucose and HbA1c, and an increase in fasting insulin, supporting its role as an adjunct therapy for diabetes management.
https://pubmed.ncbi.nlm.nih.gov/35558998/ – This publication is likely a related or identical study to the first source, focusing on the efficacy of Juglans regia L. leaf extract. It reinforces findings on improved glycemic parameters like fasting blood glucose and insulin levels in diabetic patients, contributing to the overall evidence base.
https://www.ijpsonline.com/articles/insights-of-pharmacological-activities-patents-and-clinical-applications-of-polyphenolic-compounds-enriched-nuts-of-emjuglans-regi-5638.html?view=mobile – This narrative review discusses the pharmacological activities, patents, and clinical applications of polyphenolic compounds found in Juglans regia. It provides broader context on the bioactive components and their potential health benefits, including glycemic control, aligning with the findings from the meta-analyses.
https://www.koreascience.kr/article/JAKO202230243211078.page – This source likely refers to one of the individual RCTs included in the meta-analysis, or a related study from the same research group. It would detail specific methodologies and outcomes for a single trial, contributing to the pooled data on walnut leaf extract's effects on glycemic markers.
https://www.cir-safety.org/sites/default/files/117_Buff1.pdf – This source appears to be a safety assessment document, possibly from a regulatory body, concerning an ingredient. While not directly about walnut leaf extract's efficacy in diabetes, it provides crucial information on the general safety profile of botanical extracts, which is relevant for understanding the overall safety of the supplement.

Score: 60/100