Watermelon Powder
Also known as: Watermelon, Watermelon Powder, Citrullus lanatus
Overview
Watermelon powder is derived from Citrullus lanatus, a fruit known for its rich nutrient profile, particularly the amino acid L-citrulline. This dietary supplement is primarily utilized for its antioxidant properties and its potential role in supporting cardiovascular health and muscle recovery. Research indicates its potential to influence blood pressure and cholesterol levels, as well as mitigate muscle soreness. While promising, the evidence base is still developing, with a recognized need for more rigorous and comprehensive studies to fully elucidate its benefits and limitations. It is available in various forms, often as a dried powder or extract.
Benefits
Watermelon consumption has demonstrated potential cardiovascular benefits, including significant decreases in systolic blood pressure, total cholesterol, and LDL cholesterol, as evidenced by a meta-analysis of randomized controlled trials. These effects suggest a role in managing cardiovascular diseases. Furthermore, due to its L-citrulline content, watermelon powder may aid in reducing muscle soreness, particularly beneficial for athletes post-exercise. Some evidence also points towards improved vascular function, though this area requires further investigation. The strength of evidence for blood pressure and cholesterol reduction is moderate, with observed significant effect sizes, while the evidence for muscle soreness reduction is promising but based on smaller studies. The time course for these benefits is not yet clearly established.
How it works
The primary mechanism of action for watermelon powder's benefits centers on its L-citrulline content. Once ingested, L-citrulline is converted into L-arginine within the body. L-arginine then serves as a precursor for nitric oxide (NO) production. Nitric oxide is a potent vasodilator, meaning it helps relax and widen blood vessels, thereby improving blood flow and potentially leading to a reduction in blood pressure. This interaction primarily affects the cardiovascular system by enhancing vascular function. The nitric oxide pathway is considered the key molecular target. L-citrulline from watermelon is generally well absorbed, especially when consumed in its natural, unheated form.
Side effects
Watermelon powder is generally considered safe for consumption, though comprehensive data on its long-term use is still emerging. Common side effects are not extensively documented, but gastrointestinal upset is a possibility, especially with higher doses. Uncommon side effects may include potential allergic reactions in sensitive individuals. Rare side effects are not well-documented. It is important to note that watermelon powder may interact with certain medications, particularly those affecting blood pressure or the nitric oxide pathway, such as nitrates or erectile dysfunction medications. While no absolute contraindications are well-established, individuals with pre-existing medical conditions, particularly those related to blood pressure regulation or kidney function, should exercise caution. Pregnant or breastfeeding women are advised to consult a healthcare provider before incorporating watermelon powder into their regimen due to limited safety data in these populations.
Dosage
The minimum effective dose for watermelon powder is not definitively established, but research studies frequently utilize amounts that provide between 1 to 5 grams of L-citrulline. Therefore, an optimal dosage range typically falls within 1-5 grams of L-citrulline per day. The maximum safe dose has not been well-defined, and exceeding recommended amounts without professional guidance is not advised. For muscle benefits, it is often recommended to take watermelon powder before exercise. For cardiovascular effects, consistent daily intake may be more beneficial. The form of consumption can influence absorption; natural watermelon juice may offer better bioavailability compared to pasteurized or highly processed forms, as heat treatment can affect L-citrulline's efficacy. No specific cofactors are known to be required for its absorption or action.
FAQs
How often should watermelon powder be consumed for optimal benefits?
Consistent daily intake may be beneficial for cardiovascular health, while pre-exercise timing is suggested for muscle benefits.
Is watermelon powder safe for everyone?
Generally safe, but consult a healthcare provider if you have specific medical conditions or are taking medications.
When is the best time to take watermelon powder?
Before exercise for muscle recovery or consistently throughout the day for cardiovascular benefits.
What benefits can be expected from watermelon powder?
Potential reductions in blood pressure, cholesterol, and muscle soreness are among the expected benefits.
Does watermelon powder have significant effects on weight loss?
There is currently no strong scientific evidence to support the use of watermelon powder specifically for weight loss.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/37369281/ – This meta-analysis of 9 randomized controlled trials investigated the effects of watermelon supplementation on cardiovascular disease risk factors. It found significant reductions in systolic blood pressure, total cholesterol, and LDL cholesterol, indicating potential antihypertensive effects. However, it also noted an increase in fasting blood sugar. The study highlighted limitations such as heterogeneity and limited sample sizes, suggesting moderate quality evidence.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9592950/ – This meta-analysis explored the impact of L-citrulline supplementation and watermelon consumption on vascular function. It suggested potential improvements in vascular health, contributing to better cardiovascular outcomes. The review emphasized the need for more well-designed, longer-term studies to confirm these findings, indicating a moderate quality of evidence due to existing study limitations.
- https://pubs.acs.org/doi/abs/10.1021/jf400964r – This in vitro and in vivo study examined the effects of watermelon juice on muscle soreness and recovery heart rate in athletes. It demonstrated that watermelon juice, likely due to its L-citrulline content, could reduce muscle soreness post-exercise. The study involved a small sample size of 7 athletes, limiting the generalizability of its findings and suggesting a low to moderate quality of evidence.
Supplements Containing Watermelon Powder

Water Away with Dandelion & Potassium
ZHOU Nutrition

One Daily Multivitamin
Nature's Lab

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Armor-V Multi-Nutrient Complex
MP MusclePharm

Six Daily Advanced Multivitamin
Nature's Lab

Super Reds Capsules
Purity Products

Alpha Dry
IMSOALPHA
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Water Away
Phytoral
Ruby Reds
New Vitality