White Atractylodes Root Extract
Also known as: White Atractylodes, Bai Zhu, *Atractylodes macrocephala*
Overview
White Atractylodes, derived from the rhizome of *Atractylodes macrocephala*, is a prominent herb in Traditional Chinese Medicine (TCM). Traditionally, it is utilized to tonify the Spleen, dry dampness, and support digestive health. Its characteristics include a bitter, sweet, and warm nature, contributing to the Earth element in TCM. Modern applications encompass enhancing immune function and regulating gut microbiota. Although research into its pharmacological effects is ongoing, current studies are increasing in scope and quality, revealing promising therapeutic benefits. However, while systematic reviews and meta-analyses exist, further high-quality randomized controlled trials (RCTs) are necessary to solidify its established efficacy and safety.
Benefits
White Atractylodes has shown multiple evidence-based benefits, particularly in oncology. When used alongside neoadjuvant chemotherapy, it has significantly improved the objective response rate (ORR) and disease control rate (DCR) for cancer patients, thereby reducing adverse reactions from chemotherapy. Clinical data indicate that the ORR has increased by a relative risk of 1.41 (95% CI: 1.27-1.57), and the DCR by 1.20 (95% CI: 1.13-1.27). Additional benefits may include enhanced quality of life indicators and modulation of immune responses, particularly in individuals with digestive issues or those undergoing chemotherapy treatment.
How it works
The pharmacological action of White Atractylodes is primarily attributed to its effects on gut microbiota and immune modulation. It exhibits anti-inflammatory properties that support gastrointestinal health and enhance Spleen *qi* according to TCM principles. Bioactive compounds such as sesquiterpenoids play crucial roles in these processes, although specific molecular targets and absorption mechanisms require further investigation for comprehensive understanding.
Side effects
White Atractylodes is generally considered safe when utilized appropriately, particularly in conjunction with chemotherapy. The most commonly reported side effects are gastrointestinal disturbances, although detailed literature on adverse effects in isolation is sparse. Rare side effects have been noted but are uncommon. Potential drug interactions exist, especially with medications that influence digestive functions. Caution is advised for pregnant or lactating individuals and those with severe digestive disorders or compromised immunity, as specific contraindications remain under-researched.
Dosage
The optimal dosage of White Atractylodes remains undefined as it is predominantly used in combination with other herbs in traditional formulations rather than as a standalone supplement. Generally, it is taken with meals to maximize digestive support, with various forms available including capsules and teas. While precise upper limits are not established, safety thresholds should be maintained based on individual tolerance and clinical guidance.
FAQs
Can White Atractylodes be taken with other supplements?
Yes, it is often used in combinations with other herbs to enhance its therapeutic effects.
Is White Atractylodes safe during pregnancy?
Caution is advised during pregnancy and lactation due to limited studies on its safety in these populations.
How should I take White Atractylodes for best results?
It is typically recommended to take it with meals to support digestion and enhance absorption.
What results can I expect when using White Atractylodes?
You may experience improved digestive health and enhanced immune function, particularly when combined with traditional therapies.
Is White Atractylodes a substitute for medical treatment?
No, it should not replace medical treatments but may serve as a complementary therapy.
Research Sources
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1431381/full – This systematic review and meta-analysis involving 1669 patients assessed the effects of White Atractylodes combined with neoadjuvant chemotherapy, demonstrating significant improvements in ORR and DCR with a notable reduction of adverse effects.
- https://pubmed.ncbi.nlm.nih.gov/39479020/ – This review highlights the traditional uses of White Atractylodes in supporting digestive health and immune function while noting the limited number of clinical trials supporting these claims.
- https://www.herbalreality.com/herb/atractylodes/ – This herbal overview discusses the modulation of gut microbiota and immune support associated with White Atractylodes, emphasizing its historical and potential contemporary applications.
- https://pubmed.ncbi.nlm.nih.gov/32987126/ – This source offers insights into the pharmacology of White Atractylodes, though its findings are not derived from clinical studies, providing an overview of its traditional applications.
- https://academic.oup.com/toxres/article/doi/10.1093/toxres/tfae035/7625491 – This article provides an assessment of the safety profile of White Atractylodes, indicating its general safety when used as indicated and in conjunction with chemotherapy.