White Button Mushroom Fruiting Body Extract
Also known as: Agaricus bisporus, White Button Mushroom
Overview
White button mushrooms (*Agaricus bisporus*) are the most commonly consumed mushrooms worldwide. As a dietary supplement, white button mushroom extract is used for its potential immune-supporting and anti-cancer properties. It contains phytochemicals, including conjugated linoleic acid (CLA). Research suggests potential benefits in prostate cancer, including inhibiting cancer cell proliferation and modulating immune responses. The extract is available in various forms, such as capsules and tablets. While generally considered safe as a food, more research is needed to fully understand the long-term effects and optimal usage of the extract as a supplement. The mushrooms are cultivated globally, making the extract readily accessible.
Benefits
White button mushroom extract has shown potential in inhibiting prostate cancer cell proliferation and enhancing immune function. In vitro studies indicate that the extract can induce apoptosis in prostate cancer cells. Clinical trials suggest that it may reduce myeloid-derived suppressor cells (MDSCs) in patients with prostate cancer, potentially boosting anti-cancer immune defenses. The extract may also enhance innate immunity by increasing natural killer (NK) cell activity and cytokine production, such as IFN-γ and TNF-α. These benefits are most studied in the context of prostate cancer and immune system modulation. However, the effect sizes and clinical significance are not fully quantified due to the limited number of human studies, and the duration of supplementation required to observe benefits is not well-defined.
How it works
White button mushroom extract likely modulates immune responses, including enhancing NK cell activity and reducing MDSCs, which can suppress immune responses in cancer. It interacts with the immune system, potentially affecting cancer cell growth and proliferation. Phytochemicals like CLA may play a role in its anticancer effects. Specific molecular targets are not well-defined, and the bioavailability of the active compounds in white button mushroom extract is not well-studied. Further research is needed to fully elucidate the mechanisms of action and absorption characteristics.
Side effects
White button mushroom extract is generally considered safe when consumed as food, but long-term supplementation data are limited. Common side effects are not well-documented for supplementation. Potential gastrointestinal upset is possible, though not commonly reported. Rare side effects are unknown due to limited long-term studies. Potential interactions with immunosuppressive drugs or cancer treatments are speculative and require further study. Caution is advised in immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers due to limited data. More comprehensive research is needed to fully assess the safety profile of white button mushroom extract supplementation.
Dosage
A minimum effective dose for white button mushroom extract supplementation has not been established. Clinical trials have used various forms and dosages, but specific optimal ranges are not defined. The maximum safe dose is also not established. There are no specific timing recommendations available. Capsules or tablets are common forms, but bioavailability may vary. Absorption factors and required cofactors are unknown. Due to the lack of established guidelines, it is important to consult with a healthcare professional before starting supplementation with white button mushroom extract.
FAQs
How can I safely incorporate white button mushroom extract into my diet?
Consult with a healthcare provider before starting any new supplement. Begin with a low dose and monitor for any adverse effects. Ensure the supplement is from a reputable source.
Are there any known interactions with medications or health conditions?
Potential interactions with immunosuppressive drugs or cancer treatments are speculative and require further study. Caution is advised in immunocompromised individuals. Always consult with a healthcare provider.
What results can I expect from taking white button mushroom extract?
Expected results are variable, depending on individual health status and supplementation context. Research suggests potential benefits in prostate cancer and immune system modulation, but more studies are needed.
Is white button mushroom extract a proven cancer treatment?
No, it is not a proven cancer treatment. While research shows potential benefits, it should not be used as a substitute for conventional medical care. Always consult with healthcare providers.
Research Sources
- https://www.sciencealert.com/mushroom-extract-shows-promising-effects-against-prostate-cancer – This article summarizes a phase II clinical trial and mouse model study that found white button mushroom extract can delay tumor growth and reduce MDSCs in prostate cancer patients. The study suggests that the extract modulates the immune system, potentially enhancing anti-cancer defenses.
- https://pubmed.ncbi.nlm.nih.gov/19005974/ – This study investigates the antiproliferative effects of white button mushroom extract on prostate cancer cells. The results demonstrate that the extract inhibits prostate cancer cell proliferation and induces apoptosis, highlighting its anticancer potential in vitro and in vivo.
- https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.3175 – This study examines the effect of dietary supplementation with white button mushrooms on innate immunity in mice. The findings indicate that supplementation enhances innate immunity by increasing NK cell activity and cytokine production, suggesting potential immune benefits.
- https://pubmed.ncbi.nlm.nih.gov/17513409/ – This research explores the impact of white button mushroom consumption on immune function. The study provides evidence that dietary supplementation with white button mushrooms can enhance immune responses, particularly by increasing NK cell activity.
- https://www.sciencedaily.com/releases/2024/01/240108125753.htm – This science daily article reports on a recent study showing that white button mushroom extract can delay tumor growth and reduce MDSCs in prostate cancer patients. The research suggests that the extract modulates the immune system, potentially enhancing anti-cancer defenses.
Recommended Articles
Best Ingredients for Healthy Hair Growth
Vitamins D, iron, zinc, and natural oils like rosemary are crucial for healthy hair growth.
Mushroom Supplement Extraction: Enhancing Potency
Extraction is essential to unlock the full potency of certain mushroom supplements like Reishi, Cordyceps, and Lion's Mane.
Vitamin D2 vs D3: Optimal Doses & Benefits
Vitamin D3 is more effective than D2 in raising vitamin D blood levels, with recommended doses varying based on individual needs.
Top Adaptogens for Stress Relief: A Scientific Guide
Adaptogens like Ashwagandha, Rhodiola, and Holy Basil are effective for stress relief, supported by clinical evidence.