Zhu Ling Sclerotium Extract
Also known as: Poria cocos sclerotium extract, Wolfiporia extensa sclerotium extract, Zhu Ling, Fu Ling
Overview
Zhu Ling, derived from the dried sclerotium of the fungus Poria cocos (also known as Wolfiporia extensa), is a medicinal mushroom widely used in Traditional Chinese Medicine (TCM). It grows on pine roots and is valued for its diuretic and spleen-supporting properties. The extract contains polysaccharides, triterpenoids, and other bioactive compounds believed to modulate immune function and reduce inflammation. Traditionally, it is used to promote urination, reduce edema, and support kidney function, often as part of multi-herb formulas like Wuling powder. While research on isolated Zhu Ling extract is limited, studies on TCM formulas containing Zhu Ling suggest potential benefits for kidney-related conditions. Further research is needed to fully elucidate its mechanisms and isolated effects.
Benefits
The primary benefit associated with Zhu Ling, particularly when used in conjunction with other herbs in TCM formulas like Wuling powder, is its diuretic and kidney-supportive effects. A meta-analysis of Wuling powder showed significant improvements in 24-hour urine volume and a reduction in 24-hour urine protein in patients with diabetic nephropathy, suggesting a renal-protective effect. Secondary benefits may include immune modulation and anti-inflammatory effects, inferred from TCM use and some preclinical studies, although direct clinical evidence for these effects from isolated Zhu Ling extract is limited. Patients with kidney-related disorders, particularly diabetic nephropathy, may experience the most benefit from formulas containing Zhu Ling.
How it works
Zhu Ling's mechanism of action is not fully elucidated, but it is believed to exert its diuretic effects through modulation of renal tubular function and fluid balance. The anti-inflammatory and immunomodulatory effects are thought to be mediated by polysaccharides and triterpenoids, which influence cytokine production and immune cell regulation. Some evidence suggests that TCM formulas containing related herbs can modulate Th17/Treg cell balance and inflammatory pathways. Zhu Ling primarily affects the renal and immune systems. The bioavailability of its active compounds, such as polysaccharides and triterpenoids, can vary depending on the extraction methods used.
Side effects
Zhu Ling is generally considered safe when used in traditional doses within TCM formulas. Common side effects are rare, with mild gastrointestinal discomfort occasionally reported. Uncommon side effects, occurring in 1-5% of users, may include allergic reactions, although these are rare. There are no significant rare side effects reported in high-quality studies. Potential drug interactions may occur with diuretics or immunosuppressants, but clinical data are limited. Caution is advised in patients with dehydration or electrolyte imbalance. Limited data are available regarding its use during pregnancy, lactation, or in pediatric populations. It is important to consult with a healthcare provider before using Zhu Ling, especially if you have any underlying health conditions or are taking other medications.
Dosage
The minimum effective dose of isolated Zhu Ling extract is not well established. Traditional TCM formulas typically use 9-15 grams of dried sclerotium in prescriptions. The maximum safe dose is not clearly defined, and adherence to traditional dosing is recommended. Zhu Ling is usually administered orally as a decoction or extract, multiple times daily. It is often used as part of complex herbal formulas rather than as an isolated extract. The extraction method and co-administration with other herbs can affect its bioavailability. Due to limited research on isolated Zhu Ling, it's crucial to consult with a qualified healthcare practitioner for appropriate dosing and usage guidelines.
FAQs
Is Zhu Ling extract effective alone?
Most clinical evidence supports its use within multi-herb formulas. Data on the efficacy of isolated Zhu Ling extract are limited. Consult a healthcare provider for guidance.
Is it safe for long-term use?
Generally safe when used as directed in TCM. However, long-term safety data are limited. Monitor for any adverse effects and consult a healthcare provider.
How soon can benefits be expected?
Improvements in kidney function markers have been observed within weeks to months in clinical studies of formulas containing Zhu Ling. Individual results may vary.
Can it be combined with conventional medications?
Caution is advised. Consult a healthcare provider before combining Zhu Ling with conventional medications due to potential interactions.
Research Sources
- https://onlinelibrary.wiley.com/doi/10.1155/2022/1720749 – This systematic review and meta-analysis of 24 RCTs found that Wuling powder, which includes Zhu Ling, significantly increased 24-hour urine volume and decreased 24-hour urine protein in diabetic nephropathy patients. The study indicates a renal protective effect of the formula, although the specific contribution of Zhu Ling is not isolated.
- https://journals.sagepub.com/doi/10.1177/15347354221081214 – This article discusses the use of traditional Chinese medicine in treating ulcerative colitis. It highlights that combined probiotics and TCM can reduce recurrence rates in ulcerative colitis, implying immune modulation by TCM components, potentially including Zhu Ling, although the specific role of Zhu Ling is not clearly defined.
- https://onlinelibrary.wiley.com/doi/10.1155/2022/4654793 – This study investigates the effects of a traditional Chinese medicine formula on ulcerative colitis. The research suggests that the formula can improve symptoms and reduce inflammation in patients with ulcerative colitis, indicating the potential for TCM, including components like Zhu Ling, to modulate the immune response in inflammatory bowel diseases.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.844961/full – This review discusses the potential of traditional Chinese medicine in treating various diseases. It highlights that TCM formulas containing related herbs can modulate immune cell balance, suggesting immunomodulatory potential relevant to Zhu Ling's effects, although direct evidence for isolated Zhu Ling is limited.
