ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2026 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Betaine Anhydrous (TMG)

Betaine Anhydrous (TMG)

BulkSupplements.com

#Other
75
Safety80
Efficacy70
Transparency90
Based on Examine, Wikipedia, and 23 other sources

Overview

Betaine anhydrous, also known as trimethylglycine (TMG), is a compound involved in methylation and osmoregulation. Research suggests it is effective at reducing homocysteine levels, which may support cardiovascular health. While some research indicates a possible ergogenic effect, results are not consistent. The product provides a single ingredient at a dose supported by some research, but may be lower than what's needed for full benefit for different use cases.

The Good

Supports methylation processes

May promote cardiovascular health by reducing homocysteine levels

Acts as an osmolyte to support cell hydration

The Bad

May cause diarrhea at high doses

May increase total cholesterol and LDL-cholesterol levels at high doses

Individual responses can vary

Is it for you?

Best For: Individuals seeking cardiovascular support, athletes, those interested in liver health

Skip If: You are pregnant or nursing, or have a pre-existing medical condition without consulting a doctor.

Ingredients Analysis

Trimethylglycine

1500 mg

How to Use

Take the recommended serving size, typically 1-2 grams per day, often split into multiple doses.

Frequency:

Daily

Best Time:

Anytime

When:

With or without food

Who Should Use This

Best For:

Individuals seeking cardiovascular support, athletes, those interested in liver health