ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Goldenseal Herb 4:1 Extract Powder

Goldenseal Herb 4:1 Extract Powder

TerraVita Premium Collection

#Other
70
Safety72
Efficacy68
Transparency62
Based on Examine, Wikipedia, and 23 other sources

Overview

This Goldenseal Herb 4:1 Extract provides a substantial daily dose of 3000 mg, leveraging the traditional uses of goldenseal for immune and digestive support. While goldenseal contains berberine, a well-researched compound with metabolic and antimicrobial benefits, the efficacy of the whole goldenseal extract itself is less substantiated by large-scale clinical trials compared to isolated berberine. The lack of standardization to active compounds makes precise efficacy assessment challenging.

The Good

Contains a Concentrated Extract: The 4:1 extract indicates a more potent form compared to raw herb powder.

Delivers a High Daily Dose: With 3000 mg per day, the product provides a significant amount of goldenseal.

Traditional Use for Immune and Digestive Support: Goldenseal has a long history of use in traditional medicine for these applications.

The Bad

Limited Clinical Evidence for Whole Goldenseal: Most robust research focuses on berberine, not the full goldenseal extract, making direct efficacy claims for this product difficult.

Potential for Drug Interactions: Goldenseal can inhibit CYP enzymes and P-glycoprotein, significantly affecting the metabolism of numerous medications, leading to increased drug levels and side effects.

Insufficient Long-Term Safety Data: While generally safe for single doses, long-term safety of goldenseal extract is not well-established.

Is it for you?

Best For: Individuals seeking natural immune and digestive support

Skip If: Pregnant, breastfeeding, or have certain medical conditions without consulting a healthcare provider.

Ingredients Analysis

Goldenseal Herb Extract; Powder

1000 mg

How to Use

Mix powder with water or preferred beverage. Follow dosage instructions on product packaging.

Frequency:

Daily

Best Time:

Anytime

When:

As directed on packaging

Who Should Use This

Best For:

Individuals seeking natural immune and digestive support

Similar Products

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement by Vetriscience®

Vetri-Science® Laboratories Healthymouth™ Natural Zeolites for Dogs & Cats Dental Health Supplement

Vetriscience®

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT by GNARLY®

COLLAGEN PRO Pasture Raised Peptides UNFLAVORED DIETARY SUPPLEMENT

GNARLY®

Muscle memory Creatine Powder supplement by Ora®

Muscle memory Creatine Powder supplement

Ora®

Amazing Formulas MSM (Methylsulfonylmethane) Supplement by Amazing Nutrition

Amazing Formulas MSM (Methylsulfonylmethane) Supplement

Amazing Nutrition

Fiber GDX Dietary Supplement Fiber / Orange Flavor by THE PAUSENUTRITION®

Fiber GDX Dietary Supplement Fiber / Orange Flavor

THE PAUSENUTRITION®

PROSTATE HEALTH SUPPLEMENT by OFFSTATE

PROSTATE HEALTH SUPPLEMENT

OFFSTATE

Recommended Articles

Optimal Berberine Dosing Guide

Optimal Berberine Dosing Guide

Optimal berberine intake involves 500-1500 mg/day, split 2-3 times, ideally 30-60 minutes before meals, tailored to individual needs.

Cycling Berberine: Avoid Tolerance, Maximize Benefits

Cycling Berberine: Avoid Tolerance, Maximize Benefits

Cycling berberine can help prevent tolerance and enhance its metabolic and cardiovascular benefits.

Berberine vs. Metformin: Glucose Control Efficacy

Berberine vs. Metformin: Glucose Control Efficacy

Clinical trials show berberine can effectively control glucose levels, comparable to metformin, with a different side effect profile.

Berberine vs Metformin: Weight Loss Showdown 2025

Berberine vs Metformin: Weight Loss Showdown 2025

Berberine and metformin both show promising weight loss effects by activating AMPK, with berberine possibly having a slight edge in certain populations.