ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Liver Defense

Liver Defense

Sprouts Farmers Market

#Other
48
Safety55
Efficacy40
Transparency70
Based on Examine, Wikipedia, and 23 other sources

Overview

This 'Liver Defense' supplement relies on a proprietary blend, which prevents an accurate assessment of individual ingredient dosages. While Milk Thistle is often associated with liver protection, its effectiveness is debated in high-quality trials, and its concentration in this blend is undisclosed. Other ingredients lack robust clinical support for liver health. Therefore, the overall effectiveness of this product for advertised liver defense is highly questionable due to underdosing concerns and insufficient scientific backing for many of its components.

The Good

Traditional Herbal Blend: Contains a variety of herbs historically used in traditional medicine for liver and digestive support.

Gluten-Free: Suitable for individuals avoiding gluten.

Convenient Liquid Form: Drops can be easily added to water or juice, offering an alternative to pills.

The Bad

Proprietary Blend Obscures Dosing: The exact amounts of each herb within the 500mg proprietary blend are not disclosed, making it impossible to determine if individual ingredients are present at clinically effective doses, rendering their inclusion largely theoretical.

Limited Clinical Evidence for Key Ingredients: Several ingredients, such as Oregon Grape Root, Yellow Dock Root, and Fringe Tree Bark, lack robust human clinical trials to support their efficacy for liver defense or other claims.

Potential for Drug Interactions: Ingredients like Oregon Grape Root (due to berberine) and Milk Thistle may interact with medications, specifically those metabolized by P-glycoprotein or cytochrome P450 enzymes, requiring caution and medical consultation.

Is it for you?

Best For: Individuals seeking liver support, those with lifestyle factors impacting liver health

Skip If: Pregnant, nursing, taking medication, or have a medical condition without consulting a doctor

Ingredients Analysis

Herb Weight Equivalence

500 mg

Proprietary Blend

500 mg

Oregon Grape Root

0 mg

Milk Thistle Seed

0 mg

Yellow Dock Root

0 mg

Red Root

0 mg

Dandelion Root

0 mg

Fringe Tree Bark

0 mg

Fresh Ginger Root

0 mg

How to Use

Take 1-2 capsules daily with food, or as directed by a healthcare professional.

Frequency:

Daily

Best Time:

Morning or Evening

When:

With food

Who Should Use This

Best For:

Individuals seeking liver support, those with lifestyle factors impacting liver health

Recommended Articles

Glutamine Dosage for Gut Health: A Guide

Glutamine Dosage for Gut Health: A Guide

Glutamine supports gut health with a recommended dosage of 5-30 grams per day, available in various supplement forms.

Immune Supplements & Pregnancy Safety 2025

Immune Supplements & Pregnancy Safety 2025

The safety of immune-boosting supplements during pregnancy in 2025 hinges on supplement type, dosage, and health conditions.

Top Immune Support Ingredients: What Works?

Top Immune Support Ingredients: What Works?

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

Milk Thistle & Liver Health: The Role of Silymarin

Milk Thistle & Liver Health: The Role of Silymarin

Silymarin in milk thistle significantly supports liver health by providing antioxidant properties and therapeutic effects on liver diseases.