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Aframomum melegueta seed extract

Also known as: Aframomum melegueta, Grains of Paradise, Guinea grains, Melegueta pepper

Overview

Aframomum melegueta, commonly known as Grains of Paradise, is a plant native to tropical Africa. Its seeds are used both as a spice and in traditional medicine. Historically, it has been used to treat conditions such as fever, rheumatism, and gastrointestinal disorders. The seeds are characterized by their antimicrobial properties and a pungent flavor, making them a culinary ingredient. Current research is emerging, particularly focusing on its metabolic effects, but the available evidence is limited, consisting mainly of small-scale trials and traditional use reports. It is available as a spice and in extract form.

Benefits

The primary researched benefit of Aframomum melegueta is its potential to increase whole-body energy expenditure (EE) by activating brown adipose tissue (BAT). A study indicated a maximal increase of 361 kJ/d in EE within 0.5 hours after ingesting 40 mg of the extract. Secondary benefits include potential antimicrobial and aphrodisiac properties, although these are less substantiated by clinical trials. The metabolic effects may be particularly beneficial for individuals looking to enhance their metabolic rate. However, more extensive, high-quality research is needed to confirm these benefits and understand their clinical significance fully.

How it works

Aframomum melegueta is believed to work primarily by activating brown adipose tissue (BAT), which in turn increases thermogenesis and energy expenditure. This activation influences metabolic rate. While the specific molecular targets are not yet well-defined in the current literature, the interaction with BAT suggests a direct impact on metabolic processes. Specific data on the absorption and bioavailability of its active compounds is currently lacking, requiring further investigation to fully elucidate its mechanism of action.

Side effects

Aframomum melegueta is generally considered safe when used in traditional culinary amounts, but comprehensive safety data is limited. Common side effects are not well-documented in scientific literature, but potential gastrointestinal upset may occur due to its spicy nature. Rare side effects are currently undetermined due to insufficient data. No documented drug interactions exist, but caution is advised when combining it with other metabolic enhancers. Due to a lack of data, caution is also advised during pregnancy and breastfeeding. Individuals with sensitive stomachs or allergies to spices should use it with caution.

Dosage

A minimum effective dose of 40 mg of Aframomum melegueta extract has demonstrated metabolic effects in studies. However, optimal dosage ranges are not well-established, necessitating further research. The maximum safe dose is also undefined, and caution is advised beyond traditional culinary use. The effects on energy expenditure are observed shortly after ingestion. It is typically used as a spice or in extract form. Specific absorption factors and required cofactors are currently unknown. More research is needed to establish clear dosing guidelines and safety thresholds.

FAQs

How should I use Aframomum melegueta?

Use as directed, starting with small amounts, and monitor for any gastrointestinal upset. If using an extract, follow the product's dosage recommendations.

Is Aframomum melegueta safe?

It is generally safe in traditional culinary amounts, but comprehensive safety data is lacking. Consult a healthcare provider if you have concerns.

When should I take Aframomum melegueta?

Effects are observed shortly after ingestion, so it can be taken before activities where increased metabolic rate may be beneficial.

What results can I expect?

You may experience an increased metabolic rate, but individual results can vary. It is not a proven weight loss aid, and more research is needed.

Is Aframomum melegueta a weight loss supplement?

While it may increase energy expenditure, it is not a proven weight loss aid on its own. More research is needed to determine its effectiveness for weight management.

Research Sources

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-wholebody-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D – This study investigated the effects of Aframomum melegueta extract on brown adipose tissue (BAT) activation and energy expenditure in men. The results showed that the extract increased whole-body energy expenditure by activating BAT, suggesting a potential role in metabolic regulation. The study was limited by its small sample size and short duration.
https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2023-0458.pdf – This study focused on the bioactive components of Aframomum melegueta and highlighted its potential antimicrobial and aphrodisiac properties. While not a clinical trial, it provides insights into the traditional uses and potential pharmacological activities of the plant. The research suggests that the plant's bioactive compounds may contribute to its various health benefits.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0255015 – This pilot study examined the effects of a combination therapy including Aframomum melegueta on various health parameters. While the study showed potential health benefits, the combination therapy makes it difficult to isolate the specific effects of Aframomum melegueta. The results suggest that Aframomum melegueta may contribute to the observed benefits, but further research is needed to confirm this.
https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_article – This study investigates the effects of grains of paradise extract on brown adipose tissue (BAT) activity and energy expenditure in humans. The research indicates that the extract can stimulate BAT, leading to increased thermogenesis and energy consumption. This suggests a potential role for grains of paradise in managing obesity and related metabolic disorders.
https://www.mdpi.com/1424-8247/18/5/749 – This review discusses the potential health benefits of Aframomum melegueta, including its antioxidant, anti-inflammatory, and antimicrobial properties. The review highlights the traditional uses of the plant and its potential applications in various health conditions. It emphasizes the need for further research to fully understand the mechanisms of action and clinical efficacy of Aframomum melegueta.