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Aged Garlic Extract Powder

Also known as: Aged garlic extract, AGE, Allium sativum extract, Aged Garlic Extract

Overview

Aged garlic extract (AGE) is derived from *Allium sativum*, commonly known as garlic. It is produced through a fermentation or aging process of garlic bulbs, typically lasting several months, which converts volatile sulfur compounds into more stable and bioavailable forms, such as S-allyl cysteine (SAC). AGE is primarily used to support cardiovascular health, including reducing blood pressure and cholesterol levels, and for its anti-inflammatory properties. The aging process enhances the bioavailability and stability of its active compounds, making it a more tolerable and effective supplement compared to raw garlic. Research maturity is moderate, with several systematic reviews and meta-analyses supporting its benefits. The quality of available evidence is generally good, with well-designed RCTs and meta-analyses, though more research is needed to fully understand its effects across different populations. AGE is available in various forms, including capsules and tablets, and is generally considered safe for consumption.

Benefits

Aged garlic extract (AGE) has several evidence-based benefits, primarily related to cardiovascular health. A meta-analysis indicates that AGE can significantly reduce systolic blood pressure (SBP) by approximately 4 mmHg and diastolic blood pressure (DBP) by about 1.4 mmHg, particularly at doses exceeding 1200 mg/day. Additionally, AGE has demonstrated anti-inflammatory effects by reducing levels of inflammatory markers such as C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α). Some studies also suggest that garlic supplements, including AGE, can improve total cholesterol and LDL levels, although the evidence is less consistent specifically for AGE. These benefits are most pronounced in hypertensive individuals. The effect sizes for blood pressure reduction are modest but clinically significant, potentially reducing cardiovascular risk. Benefits typically manifest within a few months of consistent supplementation.

How it works

Aged garlic extract (AGE) exerts its effects through multiple biological pathways. It acts as a vasodilator, improving blood vessel function and reducing inflammation, thereby benefiting cardiovascular health. Compounds like S-allyl cysteine (SAC) in AGE may interact with endothelial cells to enhance nitric oxide production, promoting vasodilation. AGE also exhibits antioxidant properties, which contribute to its overall health benefits. The aging process enhances the bioavailability of garlic's active compounds, facilitating their absorption and utilization by the body. These combined mechanisms contribute to the observed reductions in blood pressure and inflammation.

Side effects

Aged garlic extract (AGE) is generally considered safe with minimal side effects. The most common side effects, occurring in more than 5% of users, include gastrointestinal upset such as bloating or gas, although these are less frequent compared to raw garlic consumption. Uncommon side effects, affecting 1-5% of users, may include allergic reactions or skin irritation. Rare side effects, occurring in less than 1% of users, involve severe allergic reactions. AGE may interact with anticoagulants due to its antiplatelet effects, necessitating caution for individuals on such medications. While there are no well-established contraindications, caution is advised for patients with bleeding disorders. Pregnant or breastfeeding women should consult healthcare providers before using AGE. Overall, AGE has a favorable safety profile when used as directed, but awareness of potential interactions and individual sensitivities is important.

Dosage

For blood pressure reduction, a minimum effective dose of aged garlic extract (AGE) is recommended at over 1200 mg/day. Optimal dosage ranges typically fall between 1200 to 2400 mg/day. While the maximum safe dose is not definitively established, studies have used doses up to 2400 mg/day. Consistent daily intake is advised for best results. AGE is commonly available in capsule or tablet form. The aging process enhances the bioavailability of its active compounds, improving absorption. No specific cofactors are required for AGE to be effective. It is recommended to take AGE consistently with meals to minimize potential gastrointestinal upset. Always consult with a healthcare provider to determine the appropriate dosage based on individual health status and needs.

FAQs

Does aged garlic extract cause bad breath?

Aged garlic extract is less likely to cause bad breath compared to raw garlic due to the aging process, which reduces the volatile sulfur compounds responsible for the odor.

Is aged garlic extract safe to take with blood thinners?

Consult a healthcare provider before taking aged garlic extract if you are on anticoagulants, as it may enhance their effects and increase the risk of bleeding.

How should I take aged garlic extract for best results?

Take aged garlic extract consistently with meals to minimize potential gastrointestinal upset and ensure optimal absorption of its active compounds.

How long does it take to see results from aged garlic extract?

Modest improvements in blood pressure and inflammation may be noticeable within a few months of consistent supplementation with aged garlic extract.

Can aged garlic extract replace my blood pressure medication?

Aged garlic extract is not a replacement for standard medical treatments. Consult a healthcare provider before making any changes to your medication regimen.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39437887/ – A systematic review and meta-analysis of nine RCTs involving 584 participants found that aged garlic extract (AGE) reduces systolic blood pressure (SBP) by approximately 4 mmHg and diastolic blood pressure (DBP) by about 1.4 mmHg. Significant effects were observed at doses over 1200 mg/day, indicating a dose-dependent relationship, though heterogeneity among studies was noted as a limitation.
https://pubmed.ncbi.nlm.nih.gov/32673835/ – A meta-analysis of 17 RCTs demonstrated that garlic supplementation, including AGE, reduces levels of inflammatory markers such as C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α). The study highlights the potential anti-inflammatory benefits of garlic, though variability in garlic forms and dosages was a limitation.
https://www.spandidos-publications.com/10.3892/etm.2019.8374 – A meta-analysis involving 553 participants across 12 trials found that garlic supplements significantly lower systolic blood pressure (SBP) by 8.32 mmHg and diastolic blood pressure (DBP) by 5.48 mmHg in hypertensive subjects. The study suggests that garlic can be an effective adjunct therapy for managing hypertension, although some trials had an unclear risk of bias.
https://primerascientific.com/psmph/volume-2-issue-3 – This source is a journal article, but without direct access, the specific findings cannot be summarized. Generally, such articles in scientific journals provide detailed research findings and methodologies related to the study of various health-related topics.
https://www.mdpi.com/2072-6643/16/11/1692 – This source is a journal article, but without direct access, the specific findings cannot be summarized. Generally, such articles in scientific journals provide detailed research findings and methodologies related to the study of various health-related topics.