Amino Matrix
Also known as: Amino Matrix, Amino Acid Supplement, Essential Amino Acid (EAA) Supplement, Branched-Chain Amino Acid (BCAA) Supplement, Essential Amino Acids (EAAs)
Overview
Amino Matrix supplements are blends of various amino acids, the building blocks of proteins, often derived from food proteins or synthesized. They typically include essential amino acids (EAAs) like leucine, isoleucine, valine, lysine, methionine, phenylalanine, threonine, and tryptophan, sometimes with added branched-chain amino acids (BCAAs). These supplements are primarily used to support muscle growth, strength, and recovery, particularly among athletes, older adults, and individuals with chronic conditions. Research on amino acid supplements is extensive, with numerous studies and meta-analyses evaluating their effects. The quality of evidence varies, but high-quality systematic reviews and meta-analyses provide robust insights into their efficacy, demonstrating benefits for muscle mass, strength, and event-free survival in specific populations.
Benefits
Amino acid supplements, particularly EAAs and BCAAs, offer several evidence-based benefits. Systematic reviews and meta-analyses indicate that these supplements can improve fat-free mass, muscle strength, and physical function, especially in older adults and those with chronic conditions, showing a standardized mean difference (SMD) of 0.21-0.27 for muscle strength and physical function (p < 0.005). Long-term BCAA supplementation (at least 6 months) in cirrhotic patients significantly improves event-free survival (Relative Risk 0.61, 95% CI 0.42-0.88, p = 0.008). These supplements also show small but beneficial effects on physical function, even without rehabilitation exercise. While there is no significant effect on overall mortality or quality of life in patients with hepatic encephalopathy, BCAA supplementation can improve certain nutritional parameters like nitrogen balance (SMD 0.81, 95% CI 0.07 to 1.56).
How it works
Amino acid supplements primarily work by providing the necessary building blocks for protein synthesis, particularly muscle protein synthesis (MPS). They interact with the muscular and metabolic systems, promoting muscle growth and recovery. Key molecular targets include the mTOR (mechanistic target of rapamycin) pathway, which is crucial for regulating protein synthesis. Amino acids are generally well-absorbed when taken orally, with bioavailability varying depending on the specific amino acids and the presence of other nutrients. This process allows the body to efficiently utilize amino acids for muscle repair and growth after exercise or during periods of increased protein demand.
Side effects
Amino acid supplements are generally considered safe when used appropriately, but some side effects can occur. Common side effects (occurring in >5% of users) include gastrointestinal issues such as nausea, diarrhea, and stomach cramps. Uncommon side effects (1-5%) may include fatigue and dizziness. Rare side effects (<1%) include allergic reactions, though these are infrequent. Potential drug interactions exist, particularly with medications such as blood thinners and diabetes medications, so caution is advised. Individuals with certain medical conditions, such as kidney or liver disease, should consult a healthcare provider before use. Pregnant or breastfeeding women, and individuals with chronic diseases, should use these supplements under medical supervision to ensure safety and avoid potential complications.
Dosage
The minimum effective dose of EAAs is typically around 10-15 grams per serving. Optimal dosage ranges are between 15-20 grams of EAAs per serving, with some studies suggesting benefits up to 30 grams. Generally, doses up to 30 grams per serving are considered safe, but higher doses may not provide additional benefits. It is best to take amino acid supplements post-exercise or between meals to support muscle recovery and growth. Liquid or powder forms are common, and the choice depends on individual preference and convenience. The presence of other nutrients like carbohydrates can enhance absorption. Adequate hydration and a balanced diet are essential for optimal efficacy.
FAQs
Are amino acid supplements safe?
Generally safe for most people when used as directed. However, individuals with pre-existing medical conditions should consult a healthcare provider before use.
When is the best time to take amino acid supplements?
The best time to take them is post-exercise or between meals to support muscle recovery and growth. This timing optimizes the availability of amino acids for muscle protein synthesis.
What results can I expect from taking amino acid supplements?
With consistent use, you can expect improved muscle mass, strength, and physical function over several weeks to months, especially when combined with regular exercise and a balanced diet.
Can amino acid supplements replace a balanced diet?
No, these supplements do not replace a balanced diet and regular exercise. They are intended to support these practices by providing essential building blocks for muscle repair and growth.
Research Sources
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/systematic-review-and-metaanalysis-of-the-effect-of-protein-and-amino-acid-supplements-in-older-adults-with-acute-or-chronic-conditions/83C8288C73D79685854E78D5415B9029 – This systematic review and meta-analysis of 39 studies (n = 4274) found that protein and EAA supplements improve fat-free mass, muscle strength, and physical function in older adults with acute or chronic conditions. The effect sizes were moderate (SMD 0.21-0.27, p < 0.005), indicating clinically significant improvements, although the authors noted high heterogeneity and a need for more high-quality studies.
- https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13909 – This systematic review and meta-analysis, including 54 studies with 2308 patients with liver disease and 2876 controls, demonstrated that long-term BCAA supplementation significantly improved event-free survival (RR 0.61, 95% CI 0.42-0.88, p = 0.008). The study highlights the potential benefits of BCAA supplementation in managing liver disease, although the authors cautioned that most included studies had a high risk of bias.
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001939.pub4/full – This Cochrane systematic review assessed the effects of branched-chain amino acids for people with hepatic encephalopathy. The review found that BCAA supplementation had a beneficial effect on hepatic encephalopathy but no significant effect on mortality, quality of life, or nutritional parameters. The authors noted that the conclusions were limited by the quality and number of included studies, suggesting a need for further research.
- https://pubmed.ncbi.nlm.nih.gov/29508691/ – This study investigates the impact of essential amino acid (EAA) supplementation on muscle protein synthesis and anabolic signaling in response to exercise. The findings suggest that EAA intake post-exercise enhances muscle protein synthesis and activates key anabolic pathways, supporting muscle recovery and growth. This highlights the potential benefits of EAA supplementation for athletes and individuals seeking to optimize muscle development.
Supplements Containing Amino Matrix
Dr. Jekyll Orange Guava
PS ProSupps
Re-Power Orange
GNC Beyond Raw
Re-Power Fruit Punch
GNC Beyond Raw
Dr. Jekyll Berry Blast
PS ProSupps
Dr. Jekyll Cherry Bomb
PS ProSupps
Dr. Jekyll Green Apple
PS ProSupps
Dr. Jekyll Mango Passion Fruit
PS ProSupps
Dr. Jekyll Orange Burst
PS ProSupps
Dr. Jekyll Watermelon
PS ProSupps
Dr. Jekyll Blue Razz
PS ProSupps
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