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Angelica

Also known as: Angelica sinensis, Dong Quai, Chinese Angelica

Overview

Angelica sinensis, commonly known as Dong Quai or Chinese Angelica, is a plant native to China, primarily sourced from its root for medicinal purposes. It has been traditionally used in traditional Chinese medicine, particularly for women's health issues such as menstrual cramps and menopause symptoms. Additionally, it is explored for its potential cardiovascular and immune system support. The plant contains compounds like ferulic acid and Z-ligustilide, contributing to its pharmacological effects. Research on Angelica sinensis is ongoing, with studies exploring its antioxidant, anti-inflammatory, and potentially estrogenic properties. While some studies show promise, more rigorous clinical trials are needed to confirm its efficacy and safety. It is available in various forms, including capsules and teas.

Benefits

Some studies suggest that Angelica sinensis may improve cardiovascular health and potentially aid in the treatment of certain cancers, such as breast cancer, by sensitizing cancer cells to apoptosis. It may also have protective effects on renal function and overall survival. Traditionally, it has been used for women's health, but recent studies explore broader applications. Specific effect sizes vary by study, but some show significant benefits in certain conditions. A systematic review and meta-analysis found that *Radix Astragali* and *Radix Angelicae Sinensis* may improve pulmonary function and exercise tolerance in patients with idiopathic pulmonary fibrosis.

How it works

Angelica sinensis is believed to exert its effects through multiple biological pathways, including antioxidant, anti-inflammatory, and potentially estrogenic mechanisms. It interacts with cardiovascular, immune, and possibly reproductive systems. Compounds like Z-ligustilide may target pathways involved in apoptosis and cell cycle regulation. While the absorption and bioavailability of its compounds are not extensively studied, they are believed to be absorbed and metabolized in the liver.

Side effects

Angelica sinensis is generally considered safe when used appropriately, but potential interactions with medications and effects on estrogen-sensitive conditions need consideration. Common side effects include gastrointestinal upset and allergic reactions. Rare side effects include the potential for bleeding due to anticoagulant effects. It may interact with anticoagulants and diabetes medications. It is contraindicated in pregnancy and breastfeeding due to potential estrogenic effects. Caution is advised in patients with estrogen-sensitive cancers.

Dosage

The minimum effective dose of Angelica sinensis is not established, and optimal dosage ranges vary widely. The maximum safe dose is also not well-defined. It is often taken with meals to reduce gastrointestinal side effects. Angelica sinensis is available in various forms, including capsules and teas. Bioavailability may be influenced by the preparation method. Consult a healthcare provider before use, especially if taking medications or having underlying health conditions.

FAQs

What are the practical usage concerns for Angelica sinensis?

Consult a healthcare provider before use, especially if taking medications or having underlying health conditions. Be aware of potential interactions with medications and effects on estrogen-sensitive conditions.

How should Angelica sinensis be taken?

It is typically taken with meals to reduce gastrointestinal side effects. The form and preparation method may influence bioavailability.

What results can I expect from taking Angelica sinensis?

Expected results are variable, depending on the condition being treated. It is not a substitute for medical treatment without consulting a healthcare provider.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC7203419/ – This systematic review and meta-analysis investigates the effects of Radix Astragali and Radix Angelicae Sinensis on patients with idiopathic pulmonary fibrosis. The study suggests that these herbal remedies may improve pulmonary function and exercise tolerance in this patient population, indicating a potential therapeutic role.
https://journals.sagepub.com/doi/abs/10.1177/1934578X241309226 – This study likely explores the effects and applications of Angelica sinensis in a specific context. Further details would be needed to provide a more comprehensive summary of its findings and significance.
https://pubmed.ncbi.nlm.nih.gov/32425767/ – This study likely investigates specific aspects of Angelica sinensis, such as its chemical composition, pharmacological effects, or clinical applications. Further details would be needed to provide a more comprehensive summary of its findings and significance.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – This study explores the renoprotective effects of Angelica sinensis, suggesting dose- and time-dependent benefits. The research indicates significant survival benefits without an increased risk of hyperkalemia, highlighting its potential in renal health.
https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This research indicates that Angelica sinensis may have estrogenic effects, which could impact breast cancer prognosis. However, some compounds like Z-ligustilide show promise in sensitizing cancer cells to apoptosis, suggesting a complex interaction with breast cancer cells.