Angelica Sinensis
Also known as: Angelica sinensis (Oliv.) Diels, Dang Gui, Dong Quai, Angelica sinensis
Overview
*Angelica sinensis*, commonly known as Dang Gui or Dong Quai, is a plant native to China and widely used in Traditional Chinese Medicine (TCM). It is valued for its medicinal properties, particularly in tonifying and replenishing blood, relieving pain, and addressing female health issues. The plant contains bioactive compounds such as polysaccharides, ligustilide, and ferulic acid, which contribute to its therapeutic effects. *Angelica sinensis* is available in various forms, including capsules and teas, and is often used for menstrual irregularities, pain relief, and as a general health product. Research on *Angelica sinensis* is ongoing, with studies exploring its pharmacological effects and potential benefits. While some high-quality systematic reviews and meta-analyses exist, the overall evidence quality varies, with a mix of in vitro and animal studies contributing to the current understanding of its efficacy and safety.
Benefits
*Angelica sinensis* has shown potential benefits in several areas. Some studies suggest a positive effect on breast cancer patients, although the evidence is mixed. A systematic review and meta-analysis indicated that *A. sinensis* combined with *Radix Astragali* improved pulmonary function and exercise tolerance in patients with Idiopathic Pulmonary Fibrosis (IPF). Additionally, research suggests dose- and time-dependent renoprotective effects. The plant may be particularly beneficial for women experiencing menstrual irregularities and for individuals with IPF. However, the effect sizes vary across studies, and further research is needed to fully understand the clinical significance and time course of these benefits. The quality of evidence ranges from moderate to high, depending on the specific application.
How it works
*Angelica sinensis* exerts its effects through multiple biological pathways. It exhibits anti-inflammatory and antioxidant properties, contributing to its therapeutic benefits. The plant also possesses potential estrogenic activity, although this effect is considered weak. *Angelica sinensis* interacts with various body systems, including the cardiovascular, nervous, and reproductive systems. Its molecular targets include estrogen receptors, although its binding affinity is limited. The bioactive compounds in *Angelica sinensis* are absorbed into the body, where they can exert systemic effects. Further research is needed to fully elucidate the mechanisms of action and bioavailability of its active constituents.
Side effects
While generally considered safe when used appropriately, *Angelica sinensis* can cause side effects in some individuals. Common side effects are not well-documented, but gastrointestinal upset is possible. Uncommon side effects include allergic reactions and potential interactions with blood thinners. Rare side effects may involve severe allergic reactions. *Angelica sinensis* has the potential to interact with anticoagulants and estrogen-sensitive medications. It is contraindicated during pregnancy and breastfeeding due to a lack of safety data. Caution is advised for patients with bleeding disorders or those taking anticoagulant medications. It is important to consult with a healthcare provider before using *Angelica sinensis*, especially if you have underlying health conditions or are taking other medications.
Dosage
The minimum effective dose of *Angelica sinensis* is not well-established and varies depending on the condition being treated. Optimal dosage ranges are not standardized, as it is often used in traditional formulations. The maximum safe dose is also not well-defined, but high doses may increase the risk of side effects. For menstrual issues, it is often used in cycles. *Angelica sinensis* is available in various forms, including capsules and teas, and bioavailability may vary based on the preparation method. There are no documented required cofactors. It is crucial to consult with a healthcare provider to determine the appropriate dosage and timing for your specific needs.
FAQs
Is Angelica sinensis safe to use?
Generally safe when used appropriately, but consult a healthcare provider before use, especially if taking medications, to monitor for potential interactions.
How should I take Angelica sinensis?
Follow traditional guidelines or consult a healthcare provider for specific instructions on timing and administration based on your individual needs.
What results can I expect from using Angelica sinensis?
Results vary depending on the condition being treated. It is not a substitute for medical treatment without consultation with a healthcare professional.
Research Sources
- https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This review of *A. sinensis* in breast cancer found mixed evidence, with more recent studies suggesting positive effects. The analysis included 21 articles and indicated variable study quality and designs, leading to moderate evidence quality overall.
- https://pubmed.ncbi.nlm.nih.gov/27211015/ – This study investigates the estrogenic activity of *Angelica sinensis* extracts. It provides insights into the potential hormonal effects of the herb, which are relevant to its traditional use for women's health issues.
- https://pubmed.ncbi.nlm.nih.gov/32425767/ – A systematic review and meta-analysis on *Radix Astragali* and *Radix Angelicae Sinensis* in treating IPF found significant improvements in pulmonary function and exercise tolerance. The analysis included 17 RCTs and found improved pulmonary function and reduced adverse reactions, but was limited by variability in study designs.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – This study on the renoprotective effects of *A. sinensis* suggested dose- and time-dependent benefits. The retrospective analysis of 18,348 new users showed dose-dependent renoprotection without increased hyperkalemia risk, but the retrospective design limits the evidence quality.
