Angelica Sinensis Extract
Also known as: Dang Gui, Radix Angelicae Sinensis, Angelica Sinensis Extract
Overview
Angelica Sinensis, commonly known as Dang Gui, is a traditional Chinese medicinal herb recognized for its diverse therapeutic properties. Primarily used to replenish blood and relieve symptoms associated with female menstrual disorders, it contains bioactive compounds like polysaccharides, ligustilide, and ferulic acid. The extract is noted for its anti-inflammatory, antifibrotic, antispasmodic, antioxidant, and neuroprotective effects. It is utilized in various clinical applications, including breast cancer, idiopathic pulmonary fibrosis (IPF), and renal protection. Despite the promising findings, the effectiveness and safety of Angelica Sinensis Extract can vary, warranting careful consideration in therapeutic contexts.
Benefits
Angelica Sinensis Extract has several documented benefits, including: 1. **Breast Cancer Management**: Mixed findings exist regarding its safety and potential to enhance tamoxifen efficacy in resistant breast cancer cells, with evidence favoring safe use over safety concerns. 2. **Idiopathic Pulmonary Fibrosis (IPF)**: Meta-analysis evidence suggests it contributes positively to treatment outcomes, though evidence quality varies. 3. **Renal Protection**: Observational studies indicate a dose- and time-dependent renal protective effect, along with survival benefits in patients with renal conditions. The strength of these benefits varies, with systematic reviews providing the highest quality of evidence.
How it works
The mechanisms underlying Angelica Sinensis Extract's effects involve interaction with various biological pathways, including anti-inflammatory and antioxidant mechanisms. The active compounds, like ligustilide and ferulic acid, are thought to modulate signaling pathways involved in inflammation and cellular protection. Additionally, weak estrogenic activity has been reported, which may explain some of its effects on menstrual disorders and breast tissue. Overall, it supports the body's remission processes and proteomic adaptations in chronic conditions.
Side effects
Angelica Sinensis Extract is generally considered safe when used appropriately; however, some potential side effects include gastrointestinal discomfort, skin rash, and, in rare cases, an allergic reaction. Frequent use may cause issues like hyperkalemia, especially in individuals with renal impairment. Caution is advised for pregnant or breastfeeding women due to potential hormonal effects. Additionally, interactions with anticoagulants and medications that affect blood sugar levels have been reported, necessitating monitoring and possible dose adjustments in such cases. Overall, comprehensive safety evaluations are required to mitigate risks associated with its use.
Dosage
The recommended dosage of Angelica Sinensis Extract varies depending on the intended therapeutic effect. For general health benefits, doses typically range from 3 to 9 grams of the dried herb daily, while extracts may require lower quantities due to higher potency. It is recommended to be taken in split doses with meals to enhance absorption. For specific conditions, such as managing symptoms of IPF or renal protection, health care professionals might suggest tailored dosages. There are no established upper limits, but long-term use should be monitored, especially in individuals with existing health conditions.
FAQs
Is Angelica Sinensis safe for breast cancer patients?
Yes, studies indicate it may be safely consumed by breast cancer patients, but evidence is mixed, and hormonal effects should be considered.
Can Angelica Sinensis help with menstrual disorders?
Yes, it is traditionally used to relieve menstrual symptoms and may enhance overall reproductive health.
What are the primary benefits of using Angelica Sinensis?
Key benefits include anti-inflammatory effects, support for renal health, and potential enhancements in cancer treatment when used alongside medication.
Are there any significant side effects?
Potential side effects may include gastrointestinal issues and allergic reactions; monitoring is advised, especially in those on blood thinners.
How should Angelica Sinensis be taken for best results?
It is best taken in divided doses with meals to improve absorption and effectiveness.
Research Sources
- https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This systematic review assesses the safe consumption of Angelica Sinensis in breast cancer management, emphasizing a majority of studies supporting its use without adverse effects.
- https://pubmed.ncbi.nlm.nih.gov/27211015/ – A meta-analysis highlighting the efficacy of Radix Astragali and Radix Angelicae Sinensis for treating idiopathic pulmonary fibrosis, showing potential benefits despite varying evidence quality.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – This retrospective analysis evaluates health insurance claims data, revealing significant renal and survival benefits associated with Angelica Sinensis usage.
- https://pubmed.ncbi.nlm.nih.gov/32425767/ – A systematic review discussing the impact of herbal therapies, including Angelica Sinensis, on chronic conditions like idiopathic pulmonary fibrosis.
- https://pubmed.ncbi.nlm.nih.gov/34362631/ – Research exploring the biochemical profiles and clinical benefits of Angelica Sinensis, providing insights into its pharmacological complexity and therapeutic potential.
