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Antrodia

Also known as: Antrodia cinnamomea, Camphor fungus, Niu-chang-chih, *Antrodia camphorata*

Overview

*Antrodia camphorata* is a unique fungus native to Taiwan, known for its traditional medicinal applications. This fungus has garnered attention for its anti-inflammatory, anti-cancer, and hepatoprotective properties. It contains bioactive compounds such as terpenoids, benzenoids, lignans, and polysaccharides, which are thought to contribute to its health benefits. Although research into *Antrodia camphorata* is in its growing phases, the evidence predominantly comes from preclinical studies and small human trials, indicating a moderate level of research maturity. Its traditional use in Chinese medicine highlights the historical importance of this fungus in promoting health.

Benefits

Evidence suggests that *Antrodia camphorata* possesses notable anti-cancer and anti-inflammatory effects, with preclinical studies indicating a reduction in tumor incidence in mouse models. One significant study demonstrated that supplementation led to reduced tumor incidence in a mouse model of intestinal tumorigenesis. Additionally, its hepatoprotective effects include alleviating liver damage induced by chemotherapy agents, such as cisplatin. Specific populations, particularly those at risk for young-onset colorectal cancer, may benefit significantly from its use. However, more robust human trials are needed to confirm the strength and breadth of these benefits.

How it works

*Antrodia camphorata* exerts its effects primarily by inhibiting the Wnt/β-catenin signaling pathway, known for its role in cancer proliferation. Additionally, it modulates inflammatory responses by suppressing pro-inflammatory mediators such as TNF-α and IL-6. The fungus also positively influences gut microbiota, which plays a role in overall health and may further suppress tumorigenic pathways. Despite these findings, detailed information on absorption and bioavailability in humans remains limited, warranting further investigation.

Side effects

*Antrodia camphorata* is generally regarded as safe, but the current human data is minimal, making it difficult to assess common adverse effects. Reports of gastrointestinal disturbances have been noted, though they are rare. There are also potential interactions with chemotherapy drugs, such as cisplatin, necessitating caution in patients undergoing cancer treatment. Furthermore, while no specific contraindications have been established, individuals who are pregnant or breastfeeding should consult healthcare providers before use. Due to the lack of extensive studies, the profile of uncommon or rare side effects remains largely unknown.

Dosage

Currently, the minimum effective dose of *Antrodia camphorata* for humans has yet to be established, and recommended dosages are primarily derived from animal models. Long-term supplementation is often suggested to achieve potential effects, although specific timing and dosage guidelines for human use remain unclear. Typically, the intake is in the form of extracts or polysaccharides, and bioavailability may vary based on preparation methods. No maximum safe dose has been scientifically determined, emphasizing the need for more research.

FAQs

What should I consider before using *Antrodia camphorata*?

Consult a healthcare provider before use, especially if you are taking other medications or undergoing treatment.

Is it safe to use *Antrodia camphorata*?

While generally considered safe, human data is limited, and more studies are needed to affirm its safety profile.

How long does it take to see results?

Long-term use may be required to observe potential anti-cancer and anti-inflammatory effects.

Can *Antrodia camphorata* replace my medical treatment?

No, it should not be seen as a substitute for medical treatment; always consult a healthcare professional.

What are common misconceptions about *Antrodia camphorata*?

It is not a proven treatment for diseases without sufficient scientific evidence.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11314251/ – This study evaluates the anti-cancer effects of *Antrodia camphorata* in animal models, showing a significant reduction in tumor incidence, particularly focusing on gender-specific results.
https://www.oncotarget.com/article/4348/text/ – The research highlights the hepatoprotective effects of *Antrodia camphorata*, specifically noting its ability to reduce cisplatin-induced liver damage in preclinical settings.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1203087/full – An investigation into *Antrodia camphorata*'s mechanisms reveals its role in inhibiting tumorigenic pathways and modulating gut microbiota interactions within in vitro models.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3095428/ – This article discusses various biological activities of *Antrodia camphorata*, including its potential benefits in cancer treatment and liver health based on preliminary studies.
https://www.tandfonline.com/doi/full/10.2147/JIR.S431222 – The paper provides an overview of the pharmacological properties of *Antrodia camphorata*, emphasizing its promising effects but noting the need for more human trials to establish efficacy and safety.