Artichoke Aerial Parts Extract
Also known as: artichoke aerial parts extract, globe artichoke extract, cynara extract, Cynara scolymus L.
Overview
Artichoke aerial parts extract is derived from the leaves and flowers of the *Cynara scolymus L.* plant, which is native to the Mediterranean region. This extract is rich in phytochemicals, including caffeoylquinic acids, flavonoids like luteolin, and other bioactive compounds. Its traditional usage centers around promoting cardiovascular health and reducing oxidative stress, with systematic reviews showing its effectiveness in improving biological function across various populations. It plays a significant role in the Mediterranean diet and is recognized for its ability to enhance cholesterol levels, support liver function, and provide antioxidant protection, making it a valuable addition to dietary supplements aimed at improving health outcomes.
Benefits
Artichoke extract has been shown to improve lipid profiles by effectively reducing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Systematic reviews have demonstrated its substantial impact on managing hypertension, revealing significant decreases in both systolic and diastolic blood pressure. The extract also exhibits potent antioxidant activity, mitigating oxidative stress and supporting liver function. These benefits are particularly relevant for individuals with hypercholesterolemia and hypertension, indicating its preventive potential against cardiovascular diseases. Clinical studies highlight significant effect sizes, reaffirming the extract's efficacy and relevance in therapeutic contexts.
How it works
Artichoke extract functions primarily by modulating lipid metabolism; it inhibits dietary cholesterol absorption and enhances bile acid excretion, leading to decreased cholesterol synthesis in the liver. The bioactive compounds within the extract also exhibit antioxidant properties, scavenging free radicals and alleviating oxidative stress. Additionally, artichoke extract promotes the expression of LDL receptors, which facilitates the clearance of LDL-C from the bloodstream while boosting the activity of the body's endogenous antioxidant enzymes.
Side effects
Artichoke aerial parts extract is generally regarded as safe, with mild gastrointestinal symptoms such as nausea, bloating, and flatulence reported in over 5% of users. Allergic reactions are less common, occurring in about 1-5% of cases, while severe reactions are rare (<1%). Caution is recommended for individuals taking lipid-lowering or antihypertensive medications due to potential interactions that may amplify their effects. Pregnant or lactating women should consult healthcare professionals due to a lack of safety data in these populations. Individuals allergic to artichokes or other Asteraceae family members should avoid using this extract. Regular monitoring is advised to ensure safe usage.
Dosage
The recommended dosage of artichoke aerial parts extract typically ranges from 600 mg to 1200 mg per day, with optimal results observed between 600 mg and 1800 mg based on individual health conditions and goals. Although no defined upper safety limit exists, higher dosages remain less studied in terms of safety and efficacy. It is advisable to consume the extract with meals to enhance absorption and reduce the likelihood of gastrointestinal discomfort. The most commonly researched forms include capsules and powdered extracts, with dried leaf extracts often preferred in clinical settings. Taking the extract alongside meals rich in healthy fats may further improve its bioavailability.
FAQs
How long to see benefits?
Benefits on lipid profiles and blood pressure are typically observed within 8-12 weeks of supplementation.
What are the potential interactions?
Monitor for interactions with lipid-lowering and blood pressure medications.
What side effects may occur?
Mild gastrointestinal symptoms are the most common side effects.
Are there any allergies to consider?
Individuals with allergies to artichokes or the Asteraceae family should avoid the extract.
When is the best time to take it?
It can be taken at any time of day but is best taken with meals.
