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Atractylodes Macrocephala Rhizome Extract

Also known as: Baizhu, Atractylodes Macrocephala Rhizome, Atractylodes macrocephala Koidz.

Overview

*Atractylodes macrocephala*, belonging to the Asteraceae family, is a prominent herb in Traditional Chinese Medicine (TCM). It is primarily used for its ability to strengthen the spleen and stomach, as well as for its drying and dampening properties. The rhizome is rich in bioactive compounds such as polysaccharides, volatile oil components, and amino acids, which contribute to its pharmacological effects. Predominantly, it has applications in enhancing gastrointestinal health, regulating metabolic disorders, and potentially serving as an adjunct in cancer therapy. Although research on *Atractylodes macrocephala* is moderate, there is a growing body of evidence supporting its beneficial roles, particularly concerning its anti-inflammatory effects and impacts on gut microbiota. However, the quality of available research is mixed, necessitating further investigation to substantiate its efficacy and safety in various applications.

Benefits

[{"effect":"Gastrointestinal Health","evidence":"Improves intestinal microbiota composition and reduces inflammation.","population":"General population and those with gastrointestinal issues.","key_findings":"Research indicates significant microbial changes associated with supplementation."},{"effect":"Cancer Treatment","evidence":"Enhances overall response rate and disease control rate when used in conjunction with neoadjuvant chemotherapy for advanced gastric cancer (RR for ORR: 1.41, 95% CI: 1.27-1.57).","population":"Patients with advanced gastric cancer.","key_findings":"Systematic reviews demonstrate improved treatment outcomes."},{"effect":"Metabolic Disorders","evidence":"May alleviate blood hyperviscosity and improve metabolic parameters.","population":"Individuals with metabolic syndromes.","key_findings":"Animal studies corroborate reduced inflammation and beneficial metabolic impacts."}]

How it works

*Atractylodes macrocephala* exerts its effects through various biological pathways, predominantly by regulating gut microbiota and inhibiting pro-inflammatory pathways such as IL-6/STAT3/ESRRG. Its interaction with medicinal targets, including TLR4 and NF-κB, suggests a potent anti-inflammatory response which ultimately contributes to improved gastrointestinal health, metabolic regulation, and potential cancer therapeutic benefits.

Side effects

Generally well-tolerated when used appropriately, though comprehensive documentation of side effects is lacking. Uncommon side effects may include gastrointestinal upset, while rare ones are not well-documented. There may be potential drug interactions with medications affecting the gastrointestinal or immune systems. Caution is advised for pregnant or breastfeeding individuals due to insufficient safety data. Special consideration should be given to patients with severe gastrointestinal conditions to mitigate adverse reactions.

Dosage

The optimal dosage range for *Atractylodes macrocephala* is not well-established, but it is typically included in traditional formulations. Aqueous extracts are commonly utilized, with dosing often guided by TCM principles rather than strict clinical standards. Specific dosage for therapeutic use varies, and timing is generally considered within the wider context of a TCM regimen. Due to a lack of defined maximum doses, safe upper limits remain to be clarified through further research.

FAQs

Is *Atractylodes macrocephala* safe for long-term use?

Generally considered safe, though comprehensive safety data is lacking. Monitor for adverse effects, particularly in sensitive populations.

How should I take *Atractylodes macrocephala*?

It is often integrated into a broader TCM regimen; consult a qualified practitioner for specific administration instructions.

When can I expect to see results from *Atractylodes macrocephala*?

Results vary significantly depending on individual health conditions and treatment purposes, with some benefits observable over weeks.

Can *Atractylodes macrocephala* replace conventional treatments?

No, it should not be seen as a substitute for conventional medical treatments, but rather as a complementary approach.

Research Sources

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1102605/full – This study investigates the effects of *Atractylodes macrocephala* polysaccharides on intestinal microbiota composition, presenting moderate evidence supporting its role in gut health. However, the primary limitation was the animal model context.
https://pubmed.ncbi.nlm.nih.gov/39505223/ – In an experimental study, *Atractylodes macrocephala* was shown to alleviate blood hyperviscosity through anti-inflammatory mechanisms. The findings highlight its potential benefits in metabolic health, though further corroboration with human studies is needed.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1431381/full – Systematic review and meta-analysis indicate that *Atractylodes macrocephala* enhances the efficacy of chemotherapy in advanced gastric cancer, supporting its use as an adjunctive therapy based on high-quality patient data.