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Bifidobacterium Lactis HN019

Also known as: Bifidobacterium animalis subsp. lactis HN019, B. lactis HN019

Overview

Bifidobacterium animalis subsp. lactis HN019 is a specific probiotic strain recognized for its beneficial effects on human health, primarily targeting gut health and immune function. It is a naturally occurring bacterium found in fermented foods and is widely utilized as a dietary supplement. The primary applications of B. lactis HN019 include enhancing the body's immune response, improving the overall health of the gastrointestinal tract, and potentially aiding in the regulation of bowel movements. Research on this strain is moderately mature, with a growing body of evidence from various studies, including high-quality randomized controlled trials (RCTs) and meta-analyses, supporting its efficacy in these areas. Its mechanism involves colonizing the gut to modulate the microbiome and directly interact with immune cells, contributing to its health-promoting properties.

Benefits

B. lactis HN019 offers several evidence-based benefits, primarily focused on immune enhancement and gut health. It has been shown to significantly boost natural killer (NK) cell and polymorphonuclear leukocyte (PMN) function, which are critical components of the innate immune system. This immune-modulating effect is particularly beneficial for elderly individuals, where immune function often declines. Furthermore, B. lactis HN019 supports gut health by maintaining the integrity of the intestinal barrier, which is crucial for preventing the translocation of harmful substances from the gut into the bloodstream. It has also been associated with a reduction in the incidence of diarrhea. While there is some evidence suggesting benefits in bowel regularity, particularly for constipation, the results are mixed and less consistent compared to its immune-modulating effects. The time course for observing immune benefits can be as short as a few weeks of consistent supplementation.

How it works

B. lactis HN019 exerts its beneficial effects primarily by colonizing the gastrointestinal tract and interacting with the host's immune system and gut environment. Its main mechanism involves enhancing the function of immune cells, such as natural killer cells and polymorphonuclear leukocytes, thereby bolstering the body's defense mechanisms. It also contributes to the maintenance of a healthy intestinal barrier, which is vital for preventing the leakage of toxins and pathogens from the gut. While specific molecular targets are not fully elucidated, its actions involve modulating the gut microbiota composition and potentially influencing the gut-brain axis. As a probiotic, its 'absorption' is not traditional; rather, it involves successful colonization and survival within the gut to exert its effects.

Side effects

B. lactis HN019 is generally considered safe for consumption by most individuals. The most commonly reported side effects are mild gastrointestinal symptoms, such as bloating or gas, which are typically transient and resolve with continued use or dosage adjustment. Uncommon or rare severe side effects are not well-documented, though, like with any supplement, the potential for rare allergic reactions exists. There are no significant drug interactions reported with B. lactis HN019. While generally safe for most populations, including pregnant and breastfeeding women (though specific studies are limited), caution is advised for immunocompromised individuals. It is always recommended to consult a healthcare provider before starting any new supplement, especially for those with underlying health conditions or compromised immune systems, to ensure its suitability and safety.

Dosage

The minimum effective dose for B. lactis HN019 is typically around 5 billion colony-forming units (CFU) per day. Optimal dosage ranges from 5 billion to 50 billion CFU per day, depending on the desired effect and individual response. While a maximum safe dose is not precisely defined, doses up to 50 billion CFU per day have been used safely in studies. For best results and to enhance the survival of the live microorganisms through the acidic stomach environment, it is recommended to take B. lactis HN019 with food. This probiotic is available in various forms, including capsules and as an ingredient in fermented foods. There are no specific cofactors identified as necessary for its efficacy.

FAQs

How should I store B. lactis HN019 supplements?

To maintain the viability of the live bacteria, B. lactis HN019 supplements should be stored according to the manufacturer's instructions, often in a cool, dry place or refrigerated.

Is B. lactis HN019 safe for everyone?

It is generally safe for most individuals. However, if you are immunocompromised or have severe underlying health conditions, it is advisable to consult a healthcare provider before use.

When is the best time to take B. lactis HN019?

It is best taken with meals. This helps to protect the probiotic bacteria from stomach acid, enhancing their survival and ability to colonize the gut.

What results can I expect from taking B. lactis HN019?

You can expect enhanced immune function and potential improvements in overall gut health, including better intestinal barrier function. Results for bowel regularity can vary among individuals.

Is B. lactis HN019 a 'cure-all' for digestive problems?

No, it is not a 'cure-all'. While it supports gut health, individual responses vary, and it should be part of a holistic approach to digestive wellness, not a standalone solution.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/28245559/ – This systematic review and meta-analysis found that B. lactis HN019 significantly enhances immune function, specifically natural killer cell and polymorphonuclear leukocyte activity, particularly in healthy elderly adults. The study highlights the strain's potential for immune modulation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5372854/ – This research, likely a part of the evidence base for the meta-analysis, further supports the immune-enhancing effects of B. lactis HN019. It contributes to understanding how this probiotic strain modulates immune responses in the body.
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.790561/full – This review article provides a comprehensive overview of how B. lactis HN019 supports gut health. It emphasizes the strain's role in maintaining intestinal barrier function and its potential to reduce the incidence of diarrhea, offering a broad perspective on its gastrointestinal benefits.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824333 – This randomized controlled trial investigated the effect of B. lactis HN019 on functional constipation. The study, involving 229 participants, found no significant difference from placebo in improving complete spontaneous bowel movements, indicating mixed results for this specific application.