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Bombyx Mori L Extract

Also known as: Silkworm extract, mulberry silkworm extract, Bombyx mori pupae extract, Bombyx mori L. extract

Overview

Bombyx mori L. extract is derived from the silkworm, primarily from its pupae or larvae, and has a long history of traditional use in Asian cultures as both a food source and a medicinal ingredient. It is categorized as a nutraceutical or functional food ingredient due to its rich nutritional profile. The extract is notable for its high content of protein (up to 60% dry weight), essential amino acids, unsaturated fatty acids, minerals, and various bioactive peptides. While traditionally consumed for general well-being, modern research is exploring its potential applications in nutritional supplementation, wound healing, and metabolic health. The current research maturity level is emerging, with a growing body of evidence from systematic reviews and pilot studies, though robust human randomized controlled trials (RCTs) are still limited.

Benefits

Bombyx mori L. extract offers several potential benefits, primarily as a nutritional supplement and with emerging evidence for wound healing. As a nutritional supplement, it is highly valued for its rich protein content (up to 60% dry weight), essential amino acids, and unsaturated fatty acids, making it a promising food source, especially in regions facing malnutrition. The evidence for this is strong, supported by systematic reviews of its nutritional composition. For wound healing, pilot studies, mainly in animal models, suggest that the extract may accelerate the healing process. These studies indicate positive trends, possibly due to bioactive peptides and proteins, but the sample sizes are small, and robust quantification of effect sizes in humans is lacking, limiting clinical significance. While there's potential for metabolic health benefits, such as its use as a model for drug screening in diabetes and gout, direct human evidence is currently insufficient. The time course for wound healing effects has been observed within days to weeks in animal models, but human data are too limited to draw definitive conclusions.

How it works

The mechanism of action for Bombyx mori L. extract is multifaceted, primarily stemming from its rich composition. For wound healing, bioactive peptides and proteins within the extract are thought to promote tissue regeneration and reduce inflammation, although specific molecular targets are not fully elucidated. These compounds likely interact with growth factors, cytokines, and metabolic enzymes to support cellular repair processes. Nutritionally, the extract provides essential amino acids and fatty acids that are crucial for various metabolic processes throughout the body. It may also modulate immune responses and support overall metabolic health, though the exact pathways require further investigation. While animal studies suggest good digestibility and absorption of its proteins and lipids, human bioavailability data are not well-studied.

Side effects

While generally considered safe as a food in traditional contexts, Bombyx mori L. extract carries certain safety considerations. The most common adverse effect is allergic reactions, particularly in individuals sensitive to insects or shellfish due to potential cross-reactivity. These reactions can range from mild symptoms to, rarely, severe anaphylaxis. Gastrointestinal discomfort has been reported, but it is uncommon. There are no known significant drug interactions reported with Bombyx mori L. extract. However, it is contraindicated for individuals with known allergies to insects or shellfish. For special populations such as pregnant or lactating women and children, there is insufficient safety data to recommend its use. Consumers should be aware of the potential for microbial contamination if the product is not properly processed and handled. Overall, while generally well-tolerated, allergic potential is the primary safety concern.

Dosage

Specific dosing guidelines for Bombyx mori L. extract in humans are not well-established, as most research involves animal models or traditional food consumption. A minimum effective dose has not been determined, and optimal dosage ranges are currently undefined. Traditional food use suggests that moderate intake is generally safe. The maximum safe dose is also not established, but excessive intake could potentially increase the risk of allergic reactions. There are no specific timing recommendations for administration; it can generally be taken with meals. The extract is available in various forms, including powder, extract, or whole pupae, and bioavailability may vary between these forms. While its protein and lipid content suggest good digestibility, human absorption factors are not extensively studied. No specific cofactors are identified as necessary for its efficacy.

FAQs

Is Bombyx mori L. extract safe to consume?

It is generally safe as a food, but allergic reactions are the primary concern, especially for individuals with insect or shellfish allergies. Always check for potential allergens.

What are the main benefits of taking this extract?

Its primary benefit is as a rich nutritional supplement, providing high-quality protein, essential amino acids, and healthy fats. Emerging evidence suggests potential for wound healing, but more human research is needed.

Can I take Bombyx mori L. extract if I have allergies?

If you have allergies to insects or shellfish, it is strongly advised to avoid this extract due to potential cross-reactivity and the risk of severe allergic reactions.

What is the recommended dosage?

There is no established recommended dosage for humans. Doses vary in research, and traditional use involves moderate intake. Consult a healthcare professional for personalized advice.

Is this extract a 'miracle cure' for any condition?

No, it is not a miracle cure. Its benefits are primarily nutritional and supportive. While research is ongoing for therapeutic uses, it should not replace conventional medical treatments.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC9325104/ – This systematic review analyzed the nutritional composition of Bombyx mori pupae, concluding that they are a rich source of protein, essential amino acids, and unsaturated fatty acids. The study highlights its potential as a valuable nutritional supplement, though it notes the limited human clinical data and the prevalence of animal or in vitro studies.
https://pubmed.ncbi.nlm.nih.gov/36076388/ – This systematic review assessed the food safety of Bombyx mori by examining 65 records on microbiological, chemical, and allergenic hazards. It found that while generally safe as food, there are risks of microbial contamination and allergic reactions. The review is comprehensive but points out the heterogeneity in study designs and the limitations in clinical safety data.
https://www.mdpi.com/2305-6320/12/2/11 – This pilot study investigated the wound healing efficacy of Bombyx mori extracts in an animal model. The findings suggested that the extracts might accelerate wound healing, but the study's small sample size and methodology limit the strength of its conclusions. It provides preliminary evidence but is not sufficient for clinical recommendations.
https://www.mdpi.com/2227-9717/12/11/2594 – This research, likely a pilot study or similar, also explored the wound healing properties of Bombyx mori extracts. Similar to other preliminary studies, it indicated potential positive effects on wound repair. However, the study's limitations, including small sample size and lack of human data, mean that robust effect sizes and clinical significance could not be definitively established.
https://resjournals.onlinelibrary.wiley.com/doi/full/10.1111/phen.12421 – This source discusses the potential of Bombyx mori as a model for drug screening, particularly in conditions like diabetes and gout. It suggests that the extract could have metabolic health benefits. However, the research primarily focuses on its utility as a research model rather than providing direct human evidence for its therapeutic efficacy in these conditions.