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Bovine Anterior Pituitary

Also known as: Bovine Anterior Pituitary Extract, BAPE, Bovine Pituitary Extract, BPE, Anterior Pituitary Extract

Overview

Bovine Anterior Pituitary Extract (BAPE) is derived from the anterior pituitary gland of cattle and contains a variety of hormones and growth factors. It is primarily utilized in cell culture media to stimulate cell growth, particularly in epithelial and stem cells, due to its mitogenic properties. BAPE contains a spectrum of mitogens and growth factors. Research on BAPE is primarily focused on in vitro applications, with limited human clinical trials available. The available evidence is mainly from in vitro studies and animal models, with a lack of high-quality human clinical trials to support its use as a dietary supplement for human health benefits. Therefore, its effects and safety in humans are not well-established.

Benefits

The primary benefit of Bovine Anterior Pituitary Extract is its ability to promote cell growth in vitro, making it useful for cell culture applications, especially for epithelial and stem cells. Some studies suggest potential antioxidant effects, but this is based on limited evidence. Due to the lack of human clinical trials, there is insufficient evidence to support any specific health benefits in humans. The effects observed are primarily in cell culture settings, and the clinical significance for human health is not well-established. Further research is needed to determine if BAPE has any tangible benefits for human health.

How it works

Bovine Anterior Pituitary Extract promotes cell growth through the action of various growth factors and hormones present in the extract. These factors stimulate cell proliferation by interacting with growth factor receptors on cell surfaces, activating intracellular signaling pathways that promote cell division and growth. The extract primarily interacts with cellular systems to promote growth. The specific absorption and bioavailability of these components in humans, particularly through oral or parenteral administration, are not well-studied.

Side effects

The safety profile of Bovine Anterior Pituitary Extract is not well-documented in humans due to the limited number of human clinical trials. While it is generally considered safe for cell culture use, potential side effects in humans are largely unknown. Due to the presence of hormones and growth factors, there is a theoretical risk of interactions with other hormones or growth factors in the body. It should be avoided in conditions where uncontrolled cell growth could be harmful. Pregnant or breastfeeding women should exercise caution due to the lack of safety data. Further research is needed to fully understand the potential side effects and risks associated with BAPE in humans.

Dosage

There are no established dosage guidelines for Bovine Anterior Pituitary Extract in humans due to the lack of human clinical trials. Minimum effective dose, optimal dosage ranges, and maximum safe dose have not been determined. Timing considerations and form-specific recommendations are not applicable for human supplementation. Absorption factors for human oral or parenteral administration are unknown. Due to the limited safety data, it is not recommended for human consumption without medical supervision.

FAQs

Is Bovine Anterior Pituitary Extract safe for human consumption?

Human safety data are limited. It is generally considered safe for cell culture use, but its safety for human consumption has not been well-established. It should not be used without medical supervision.

What are the expected results of using Bovine Anterior Pituitary Extract?

In cell culture, it promotes cell growth. However, there is no evidence to suggest specific health benefits in humans. Claims of benefits for human health are not supported by clinical trials.

How is Bovine Anterior Pituitary Extract typically used?

It is primarily used in research settings for cell culture applications. It is not widely used as a dietary supplement for human health benefits due to the lack of supporting evidence.

Are there any known drug interactions?

Potential interactions with other hormones or growth factors are possible, but specific interactions have not been well-studied in humans. Caution should be exercised when combining it with other hormonal supplements or medications.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/14690452/ – A study examined the antioxidant potential of Bovine Pituitary Extract (BPE) in human prostate epithelial cells. The findings suggest that BPE may have protective effects against oxidative stress in these cells, indicating a potential role in cellular defense mechanisms.
https://pubmed.ncbi.nlm.nih.gov/5800448/ – This study investigated the effect of bovine anterior pituitary extract on lipid mobilization in rats and humans. The research highlighted the potential metabolic effects of the extract, suggesting it may influence lipid metabolism.
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.935433/full – A proteomic analysis of the hypothalamus and pituitary gland in cattle revealed significant changes in protein abundance related to puberty. While not directly related to BPE supplementation, it provides insights into the hormonal changes during development.
https://www.cellapplications.com/bpe-bovine-pituitary-extract – This resource describes Bovine Pituitary Extract (BPE) as a supplement used in cell culture media to promote cell growth. It highlights BPE's role in supporting the proliferation of various cell types, including epithelial and stem cells.
https://www.3hbiomedical.com/media-and-supplements/supplements-and-reagents/bovine-pituitary-extract-bpe – This resource provides information on Bovine Pituitary Extract (BPE) as a supplement and reagent used in cell culture. It emphasizes BPE's ability to enhance cell growth and proliferation in in vitro settings.