Bu Gu Zhi Fruit Extract
Also known as: Bu Gu Zhi, Psoraleae Fructus, Scruffy Pea, Psoralea corylifolia
Overview
Psoraleae Fructus is derived from the dried ripe fruit of *Psoralea corylifolia*, a plant prevalent in traditional Chinese medicine. It has been used historically to address a variety of health issues such as leukoderma, menstrual irregularities, and bone diseases. The fruit is rich in bioactive compounds like psoralen and isopsoralen, which contribute to its anti-inflammatory and antioxidant properties. Despite its traditional applications, the maturity of scientific research is variable, with a mix of observational and animal studies but a lack of high-quality clinical trials substantiating its efficacy and safety in humans.
Benefits
Research indicates that Psoraleae Fructus may significantly enhance bone growth, as illustrated by a study in rabbits showing a 275% increase in new bone formation when combined with collagen. Potential benefits for conditions such as osteoporosis have been noted, although most evidence pertains to animal studies rather than human populations. Additionally, its antioxidant and anti-inflammatory effects have some support, albeit less thoroughly examined in clinical trials. The existing evidence highlights the necessity for further investigation, particularly in thriving human-specific outcomes.
How it works
The active compounds in Psoraleae Fructus, especially psoralen, may influence biological pathways related to bone metabolism and oxidative stress. While the exact mechanisms are not clearly defined, it is believed that these compounds promote new bone formation and may interact with inflammation-regulating pathways, indicating a supportive role for bone health.
Side effects
Psoraleae Fructus has a notable risk profile, particularly concerning liver health; around 57% of reported adverse reactions are linked to hepatotoxicity. Common side effects include liver injury, which can be severe. Uncommon reactions may manifest as phototoxic dermatitis and allergic responses. Use in individuals with pre-existing liver conditions is contraindicated, and caution is advised for pregnant women. Additionally, Psoraleae Fructus may interact negatively with pharmaceuticals processed by the liver, underscoring the need for medical supervision during use.
Dosage
Specific dosage guidelines for Psoraleae Fructus are not well-established, typically varying within traditional Chinese medicine formulations. The lack of a minimum effective dose poses challenges, with overdoses potentially leading to hepatotoxicity. It is generally consumed as a decoction or in capsules, with no specific timing recommendations known. Variations in preparation methods may influence the bioavailability of its active compounds, and caution is warranted in determining safe upper limits.
FAQs
What should I monitor while using Psoraleae Fructus?
It's essential to monitor liver function due to the risk of hepatotoxicity.
Is it safe for people with liver conditions?
No, individuals with liver issues are advised to avoid Psoraleae Fructus.
When is the best time to take it?
There are no specific timing recommendations for taking Psoraleae Fructus.
What benefits can I expect?
Potential benefits include improved bone health, although human evidence is limited.
Can it cure bone-related conditions?
It is not a proven treatment for all bone-related conditions, and further research is needed.
Research Sources
- http://www.cjnmcpu.com/cn/article/pdf/preview/10.1016/S1875-5364(22)60234-6.pdf – This study discusses the hepatotoxic effects of Psoraleae Fructus, identifying liver injury as a common adverse reaction and emphasizing the need for further investigation into its safety profile.
- https://thegroveclinic.com.au/pages/research-on-chinese-medicine-and-osteoporosis – The article highlights various studies indicating that Chinese herbs, including Psoraleae Fructus, may positively influence bone mineral density, although specific data for Psoraleae Fructus remains limited.
- https://www.xiahepublishing.com/2835-6357/FIM-2022-00051 – This meta-analysis points out that while certain Chinese herbal treatments may improve bone health, detailed data on Psoraleae Fructus itself are sparse, highlighting the necessity for rigorous trials.
Supplements Containing Bu Gu Zhi Fruit Extract
Recommended Articles
Herbal Boosters & COVID-19 Antivirals: Safe Mix?
Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.
Top Immune Support Ingredients: What Works?
Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.
Top Anti-Inflammatory Supplement Ingredients
Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.
Best Supplements for Cortisol Reduction: A Scientific Guide
Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.