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Caralluma Fimbriata Extract

Also known as: Caralluma fimbriata, Caralluma, Slimaluma

Overview

Caralluma fimbriata is an edible cactus native to India, traditionally used in medicine and as a food ingredient. It's marketed as an appetite suppressant and weight loss supplement. The plant contains antioxidants and chemicals that may influence appetite. Research on Caralluma fimbriata is still emerging, with clinical trials yielding mixed results. Available evidence comes from small-scale studies and systematic reviews, often showing inconsistent outcomes. It is available primarily as an herbal extract in capsule form. While generally considered safe for short-term use, further research is needed to confirm its efficacy and long-term safety.

Benefits

Caralluma fimbriata extract has shown potential in reducing waist circumference (WC) and waist-to-hip ratio (WHR) in some studies. A meta-analysis indicated a significant reduction in WC by 1.59 cm and WHR by 0.06. Another study reported a more substantial reduction in waist circumference (6.5 cm) when combined with diet and exercise. Some studies suggest improvements in metabolic risk factors like systolic blood pressure and triglyceride levels, but these findings are inconsistent. The benefits are primarily observed in overweight or obese adults over a 12-week period. However, the clinical significance of these modest reductions in WC and WHR, without significant changes in body weight or BMI, remains debatable.

How it works

Caralluma fimbriata is believed to work primarily through appetite suppression, although the exact mechanisms are not fully understood. It contains chemicals that may reduce appetite and influence metabolic pathways. It may affect the gastrointestinal system by reducing hunger and the palatability of food. Research on the specific molecular targets and the absorption and bioavailability of Caralluma fimbriata extract is limited. Further studies are needed to fully elucidate its mechanism of action.

Side effects

Caralluma fimbriata extract is generally considered safe when used in doses up to 1000 mg daily for up to 12 weeks. Common side effects include constipation, nausea, and diarrhea. Less common side effects reported in some studies include palpitation, glossitis, insomnia, generalized weakness, and rashes. A rare case of transient hypertension exacerbation has been reported. Due to limited information, its use is not recommended during pregnancy or breastfeeding. Caution is advised for individuals with existing co-morbid conditions, as the extract may interact with other health conditions or treatments. There is limited information available on drug interactions.

Dosage

The optimal dosage range for Caralluma fimbriata extract is typically between 500 mg to 1000 mg per day for up to 12 weeks. Most studies used doses of 500 mg twice daily (1 g/day). The maximum safe dose is generally considered to be no greater than 1000 mg daily for up to 12 weeks. There is no specific timing recommended for the intake of Caralluma fimbriata extract. The extract is usually administered in capsule form. The absorption factors are not well-studied. There is no information on required cofactors for the effective use of Caralluma fimbriata extract.

FAQs

Is Caralluma fimbriata safe?

Caralluma fimbriata is generally safe when used as directed, but it may cause mild side effects like constipation and nausea. Consult a healthcare provider before use, especially if you have existing health conditions.

When should I take Caralluma fimbriata?

There is no specific timing recommended for intake. It can be taken at any time of the day, preferably with meals to minimize potential gastrointestinal discomfort.

What results can I expect from taking Caralluma fimbriata?

Some studies suggest modest reductions in waist circumference and WHR, but significant weight loss or appetite suppression is not consistently supported. Results may vary.

Is Caralluma fimbriata effective for weight loss?

It is often misconceived that Caralluma fimbriata is highly effective for weight loss and appetite suppression, but the evidence is mixed and generally not strong. It should not be relied upon as a primary weight loss solution.

Research Sources

https://journals.lww.com/picp/fulltext/2015/06010/to_evaluate_efficacy_and_safety_of_caralluma.7.aspx – This pilot study evaluated the efficacy and safety of Caralluma fimbriata in overweight and obese individuals. The study found no significant differences in weight, BMI, waist circumference, hip circumference, or WHR between the treatment and placebo groups, although mild side effects were reported.
https://www.webmd.com/vitamins/ai/ingredientmono-1160/caralluma – This WebMD page provides general information about Caralluma, including its uses, effectiveness, side effects, and precautions. It notes that while Caralluma is used for obesity and anxiety, the evidence for these uses is limited and further research is needed.
https://pubmed.ncbi.nlm.nih.gov/34758791/ – This systematic review and meta-analysis examined the effects of Caralluma fimbriata extract on anthropometric parameters. The analysis found significant reductions in waist circumference and waist-to-hip ratio, but no significant effects on body weight, BMI, or hip circumference, suggesting a limited impact on overall weight loss.
https://pubmed.ncbi.nlm.nih.gov/23642949/ – This randomized, double-blind, placebo-controlled trial investigated the effects of Caralluma fimbriata extract on appetite, food intake, and anthropometry in overweight adults. The study reported significant reductions in waist circumference and WHR, along with improvements in metabolic risk factors, indicating potential benefits for body composition.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6547 – This abstract likely refers to a study on Caralluma fimbriata, potentially discussing its traditional uses, chemical composition, and pharmacological activities. Further details would be needed to provide a more specific summary of its findings.