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Cascara Sagrada Glycerite Liquid Extract

Also known as: Cascara Sagrada, Sacred Bark, Rhamnus purshiana

Overview

Cascara Sagrada is derived from the bark of the *Rhamnus purshiana* tree, native to North America. It has been traditionally used as a laxative due to its anthraquinone compounds, which stimulate bowel movements. The primary use is for constipation relief. It was once approved by the FDA for this purpose before being delisted due to lack of evidence in 2002. It is available in capsules and glycerite liquid extract forms. The research maturity level is moderate, with limited high-quality studies available, particularly concerning its efficacy and safety in various populations. While traditionally used, its effectiveness and safety require further rigorous scientific investigation.

Benefits

Cascara Sagrada is traditionally used to relieve constipation by stimulating peristalsis. However, there is limited scientific evidence supporting its effectiveness for this purpose. Some users report benefits for gallbladder and liver health, though these claims are largely anecdotal and not well-supported by scientific evidence. There is no specific evidence indicating benefits tailored to particular populations, such as the elderly or children. The benefits are primarily based on traditional use rather than robust clinical trials.

How it works

Cascara Sagrada works by stimulating the bowel through its anthraquinone compounds, which increase peristalsis and promote bowel movements. The exact molecular targets are not well-defined, but it is believed to interact with intestinal receptors to enhance motility. This stimulation leads to increased water and electrolyte secretion into the colon, facilitating easier passage of stool. The mechanism is primarily based on the irritant effect of anthraquinones on the intestinal lining.

Side effects

Cascara Sagrada is generally considered safe for short-term use (less than one week), but prolonged use can lead to serious side effects. Common side effects include stomach discomfort and cramps. Uncommon side effects include dehydration and electrolyte imbalance. Rare side effects include heart problems and muscle weakness. Potential interactions exist with medications affecting bowel function or electrolyte balance. It is contraindicated in pregnancy, breastfeeding, and conditions involving abdominal pain or diarrhea. Avoid use in pregnant or breastfeeding women and children. Long-term use can lead to dependence and reduced bowel function.

Dosage

The minimum effective dose is not well-established. A typical recommendation is 2 capsules (393 mg each) with water in the evening. The maximum safe dose is not defined, and long-term use should be avoided. It is best taken in the evening to facilitate morning bowel movements. It is available in capsules and glycerite liquid extract forms. Due to the potential for side effects and dependence, it is crucial to adhere to short-term use guidelines and avoid exceeding recommended dosages.

FAQs

How should I use Cascara Sagrada?

Use sporadically for constipation relief; avoid long-term use to prevent dependence and potential side effects.

Is it safe to use during pregnancy or breastfeeding?

No, it is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.

When is the best time to take it?

Take it in the evening with water to facilitate bowel movements in the morning.

How quickly can I expect results?

You can expect relief from constipation within a day or two of taking Cascara Sagrada.

Is it effective for colon cleansing before procedures?

No, the belief in its effectiveness for colon cleansing before procedures is not supported by evidence.

Research Sources

https://www.ncbi.nlm.nih.gov/books/NBK548113/ – This source provides general information about herbal medications and their potential interactions. It serves as a broad reference for understanding the context of herbal supplement usage and safety considerations.
https://pubmed.ncbi.nlm.nih.gov/39766936/ – This study investigates the effects of anthranoid laxatives on rat intestinal mucosa. It provides insights into the potential mechanisms and impacts of these laxatives on the intestinal lining, contributing to the understanding of their physiological effects.
https://www.webmd.com/vitamins/ai/ingredientmono-773/cascara-sagrada – WebMD provides consumer-oriented information about Cascara Sagrada, including its uses, side effects, and precautions. It serves as a general reference for individuals seeking basic information about the supplement.
https://www.herbstoponline.com/products/cascara-sagrada-capsules – This is a product page for Cascara Sagrada capsules, offering information on dosage and usage. It provides practical details for consumers interested in using the supplement.