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Celastrus Paniculatus Seed Extract

Also known as: Jyotishmati, Malkangni, Celastrus paniculatus

Overview

*Celastrus paniculatus* is an evergreen climbing shrub native to India and Southeast Asia. Its seeds and seed oil are utilized in traditional medicine for their nootropic and neuroprotective properties. This herb is characterized by high concentrations of sesquiterpenes, alkaloids, flavonoids, and essential fatty acids. Traditionally, it is employed to address neurological disorders, enhance cognitive function, and alleviate various health ailments. The level of research on *Celastrus paniculatus* is moderate; most studies have been conducted on animals or in vitro, and further human trials are required to establish its efficacy and safety for broader use. Despite the limited human data, preliminary findings have shown promise in promoting cognitive function and providing neuroprotective effects.

Benefits

Evidence-based benefits of *Celastrus paniculatus* include improvements in cognitive function and neuroprotection, predominantly observed in animal studies. Antioxidant properties have been confirmed in both animal and in vitro experiments, which adds to its potential as a neuroprotective agent. Additionally, secondary effects such as anti-inflammatory and anti-arthritic virtues have been noted, suggesting its usefulness for individuals suffering from inflammatory conditions. Although specific effect sizes in humans are inadequately documented, animal studies demonstrate significant positive outcomes for those with cognitive impairments or neurological disorders. The clinical significance of observed benefits in humans still requires extensive research.

How it works

The primary mechanisms of action of *Celastrus paniculatus* include its antioxidant activity, modulation of glutamate receptors, and potential inhibition of acetylcholinesterase. This herb interacts with the central nervous system and has been shown to influence respiratory and inflammatory pathways. By targeting glutamate receptors and affecting acetylcholinesterase, it may help in protecting neurons from excitotoxicity and promoting cognitive health, although detailed studies on bioavailability in humans are lacking.

Side effects

The safety profile of *Celastrus paniculatus* is generally regarded as favorable, especially in traditional applications; however, comprehensive safety data in humans remain insufficient. Common and uncommon side effects are not well-documented, and reports of rare side effects are similarly limited. Potential drug interactions may arise when used alongside central nervous system medications due to its neuroactive properties. The contraindications for this herb are not well-established, yet caution is advised for pregnant or breastfeeding women, as safety data in these populations is lacking. Overall, while it is traditionally considered safe, individuals should consult healthcare providers before incorporating this supplement.

Dosage

Currently, the minimum effective dose of *Celastrus paniculatus* has not been determined in human studies. Traditional medicine practices use this herb without standardized dosing protocols, and optimal dosage ranges remain unclear. No maximum safe dose has been established, and timing considerations for administration are not well-researched. The most common forms used include seed extracts or oil, though the factors influencing their absorption are not thoroughly studied. Due to the ambiguity surrounding effective and safe dosing, consulting a healthcare professional is recommended.

FAQs

Is *Celastrus paniculatus* safe to use?

Generally considered safe in traditional use, but comprehensive human safety data are lacking. Consult a healthcare provider before use.

What are the expected results from taking *Celastrus paniculatus*?

Potential benefits include cognitive enhancement and neuroprotection based on animal studies, but results may vary.

How should *Celastrus paniculatus* be taken?

Traditionally, seed extracts or oil are common. Dosage timing and administration are not well-studied, so consult a healthcare provider.

Are there any known side effects?

Common and rare side effects are not well-documented. Monitor for any unusual reactions, and consult healthcare providers if concerned.

Research Sources

https://phcog.com/article/sites/default/files/PhcogMag-18-78-400.pdf – This paper discusses the pharmacological properties of *Celastrus paniculatus*, including its nootropic activity and potential health benefits, primarily supported by animal studies.
https://pubmed.ncbi.nlm.nih.gov/34529902/ – This study investigates the neuroprotective effects of aqueous extracts of *Celastrus paniculatus* seeds, which were shown to protect against glutamate-induced neurotoxicity in neuronal cell cultures, suggesting its viability as a neuroprotective agent.
https://www.mdpi.com/2072-6643/15/11/2502 – A review focusing on the antioxidant effects of *Celastrus paniculatus* highlights its potential therapeutic applications and need for further exploration, especially in human trials.
https://pubmed.ncbi.nlm.nih.gov/15234755/ – This article provides insights into the phytochemistry and pharmacology of *Celastrus paniculatus*, noting its traditional usages and potential neuroprotective properties.
https://www.degruyter.com/document/doi/10.1515/jcim-2021-0448/html?lang=de – The review outlines various health benefits attributed to *Celastrus paniculatus*, emphasizing its roles in cognitive enhancement and inflammatory response modulation, while calling for more rigorous human trials.