Celery Stalk Powder
Also known as: Celery, celery stalk, celery seed, celery stalk powder, Apium graveolens
Overview
Celery stalk powder is derived from the stalks of *Apium graveolens*, a plant widely recognized as a vegetable and traditional medicine. This botanical supplement contains a rich profile of bioactive compounds, including flavonoids, phthalides, and phenolic acids. Its primary application is in supporting cardiovascular health, particularly in the management of hypertension, owing to its demonstrated antioxidant, anti-inflammatory, and antimicrobial properties. Research on celery's efficacy is moderately mature, with a growing body of evidence from randomized controlled trials (RCTs) and meta-analyses. While some conflicting results exist, the overall quality of evidence is improving, with systematic reviews and well-controlled clinical trials supporting its benefits. It is available in various forms, with standardized extracts often preferred for consistent dosing of active compounds.
Benefits
The most significant and well-supported benefit of celery stalk powder and its extracts is blood pressure reduction. A meta-analysis of multiple RCTs demonstrated significant improvements in both systolic and diastolic blood pressure, with clinically relevant reductions observed. For instance, some studies reported reductions from approximately 141 to 130 mmHg for systolic and 92 to 84 mmHg for diastolic pressure in hypertensive adults, comparable to mild antihypertensive medications. These effects are primarily attributed to phthalides and other bioactive compounds. While less consistent, some research also suggests potential improvements in hyperglycemia and hyperlipidemia, indicating broader metabolic benefits. Additionally, in vitro and in vivo studies have shown antioxidant and anti-inflammatory effects, which contribute to its cardiovascular protective properties. Antimicrobial activity against various pathogens has also been documented, supporting its traditional uses. Adults with hypertension are the primary beneficiaries, with effects typically observed within 4 to 8 weeks of consistent supplementation.
How it works
Celery's therapeutic effects are primarily mediated by its bioactive compounds. Phthalides, such as 3-n-butylphthalide, are key contributors, promoting vasodilation by relaxing vascular smooth muscle and increasing the availability of nitric oxide, a potent vasodilator. Flavonoids and other antioxidants combat oxidative stress, a major factor in the development and progression of hypertension and metabolic disorders. The anti-inflammatory properties of celery compounds help reduce vascular inflammation, which is also implicated in hypertension. Furthermore, some studies suggest that these bioactive compounds may modulate electrolyte balance, influencing serum sodium and potassium levels. The absorption and bioavailability of these compounds can vary depending on the preparation, with standardized extracts designed to ensure consistent delivery of active ingredients.
Side effects
Celery stalk powder and its extracts are generally well-tolerated, with a low incidence of adverse effects. Mild gastrointestinal discomfort is the most commonly reported side effect, though it is not well-documented as occurring in more than 5% of users. There are no robust reports of significant drug interactions; however, caution is advised when combining celery supplements with antihypertensive medications due to the potential for additive blood pressure-lowering effects. Individuals with known allergies to celery or other plants in the Apiaceae family (e.g., carrots, parsley) should avoid celery supplements due to the risk of allergic reactions. Safety data for special populations, such as pregnant or breastfeeding women, are insufficient, and therefore, use in these groups is not recommended without medical supervision. Overall, the safety profile is favorable for most healthy adults.
Dosage
For blood pressure reduction, the minimum effective dose of standardized celery extract appears to be around 500 mg per day, with some clinical trials utilizing up to 1000 mg per day. The optimal dosing range typically falls between 500 to 1000 mg daily, often divided into multiple doses. The maximum safe dose has not been definitively established, but doses up to 1000 mg/day have been safely used in clinical studies. Consistent daily dosing for at least 4 weeks is generally required to observe noticeable effects on blood pressure. Standardized extracts are preferred over raw powder to ensure a consistent concentration of bioactive compounds. While no specific cofactors are required, absorption may be enhanced when taken with meals.
FAQs
Is celery stalk powder effective for hypertension?
Yes, evidence from meta-analyses and RCTs supports modest but clinically relevant reductions in both systolic and diastolic blood pressure with celery preparations.
Are there risks of side effects?
Side effects are rare and generally mild, primarily involving gastrointestinal discomfort. Allergic reactions are possible in individuals sensitive to celery or related plants.
How long until benefits appear?
Benefits on blood pressure are typically observed within 4 to 8 weeks of consistent daily supplementation.
Can it replace medication?
Celery stalk powder may complement, but should not replace, prescribed antihypertensive medications without direct medical supervision.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12321563/ – This meta-analysis of randomized controlled trials found that celery preparations significantly reduced blood pressure, hyperglycemia, and hyperlipidemia. The study highlighted that the dose and specific plant part used influenced efficacy, suggesting that standardized extracts are crucial for consistent results.
- https://www.naturalhealthresearch.org/wp-content/uploads/2022/08/Celery-seed-extract-improves-blood-pressure-in-adults-with-hypertension.pdf – This crossover RCT involving hypertensive adults demonstrated significant reductions in both systolic (~11 mmHg) and diastolic (~8 mmHg) blood pressure with celery seed extract compared to placebo. The study's well-controlled design and strong statistical significance support the antihypertensive effects of celery extract.
- https://ojs.ahss.org.pk/journal/article/download/368/391/575 – This RCT investigated the effects of celery stem extract in hypertensive patients over 60 days. It reported reductions in both systolic and diastolic blood pressure, alongside improvements in serum electrolytes. The study also correlated antioxidant activity with the phenolic content of the extract.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10494649/ – This RCT, involving overweight/obese individuals with type 2 diabetes, found no significant effect of celery powder on glycemic, metabolic, or blood pressure parameters over 12 weeks. This negative finding suggests that the form of celery (powder vs. extract) and specific population may influence efficacy.
- https://journals.sagepub.com/doi/full/10.1177/1934578X251325063 – This source provides additional context on the antioxidant and antimicrobial properties of celery, supporting its traditional uses and contributing to its overall health benefits. It highlights the broad spectrum of bioactive compounds present in celery.
