Celadrin
Also known as: cetylated fatty acids, cetyl myristoleate, Celadrin cream, Celadrin gel, Celadrin
Overview
Celadrin is a proprietary blend of cetylated fatty acids synthesized through a chemical process, not found in nature. Primarily used as a topical anti-inflammatory and analgesic supplement, it targets the alleviation of symptoms associated with osteoarthritis, particularly joint pain and inflammation. The formulation is quickly absorbed through the skin and interacts with membrane receptors involved in inflammatory processes. Research on Celadrin has reached a moderate maturity level, with several clinical trials supporting its usage. However, comprehensive systematic reviews are still lacking, indicating a need for further studies to conclusively determine its efficacy and safety.
Benefits
Celadrin exhibits several evidence-based benefits, especially for individuals suffering from osteoarthritis (OA). A controlled trial with 40 knee OA patients demonstrated significant improvements in range of motion, stair climbing ability, and performance on the 'up-and-go' test within 30 minutes of application, sustained over a period of one month. Another study involving 28 patients across various OA locations recorded approximately 12% enhancements in functional metrics. Overall effect sizes ranged from 3.5% to 42%, showcasing strong potential for functional improvements in OA patients. Benefits can be observed as early as 30 minutes post-application, with cumulative advantages noted over 30 days.
How it works
Celadrin primarily interacts with membrane receptors that play essential roles in the inflammatory response. By inhibiting thromboxane production—known to promote inflammation and tissue damage—Celadrin helps modulate inflammatory processes at the cellular level. This mechanism contributes to improved joint health and pain relief, facilitated by its rapid absorption through the skin, leading to a quicker onset of therapeutic effects.
Side effects
Celadrin is generally considered safe, with clinical trials failing to report significant side effects. No common side effects exceeding 5% occurrence or significant uncommon ones between 1-5% have been recorded. Rare side effects occur in less than 1% of cases and have not been documented. Caution is warranted when used alongside other anti-inflammatory medications, although no major drug interactions have been noted. While specific contraindications have not been established, individuals with sensitive skin or known allergies should proceed cautiously. Usage in pregnant or breastfeeding women and children is not thoroughly researched, thus additional caution is advised.
Dosage
The recommended dosing for Celadrin involves topical application, typically applied twice daily for optimal results. While optimal dosage ranges are not strictly defined, consistent application is suggested to achieve the best effects. There is no established maximum safe dose; however, excessive use is not recommended. The topical cream formulation is most extensively studied and is quickly absorbed, enhancing its efficacy without requiring cofactors for absorption.
FAQs
How often should I apply Celadrin?
Typically, it is recommended to apply Celadrin twice a day for optimal results.
Can I use Celadrin with other medications?
Caution should be exercised when using Celadrin alongside other anti-inflammatory medications.
How long does it take to see benefits?
Many users report benefits as early as 30 minutes after the first application.
Is Celadrin safe for long-term use?
The current studies do not provide long-term safety data, so caution is advised for extended use.
How should I apply Celadrin?
Apply the cream topically to the affected area as needed, typically twice a day.
