Chloressence
Also known as: Chlorella, green algae supplement, Chloressence, Chlorella vulgaris
Overview
Chlorella is a genus of unicellular green algae, with *Chlorella vulgaris* being the most studied species, naturally found in freshwater environments. It is widely utilized as a nutritional supplement, often categorized as a superfood or nutraceutical, due to its exceptionally rich nutrient profile. Chlorella is packed with proteins, essential vitamins (including vitamin E), vital minerals, chlorophyll, and a variety of antioxidants. Its primary applications as a supplement revolve around general health enhancement, immune system support, and the modulation of cardiovascular risk factors. Research on Chlorella supplementation is moderately mature, with a growing body of randomized controlled trials (RCTs) and meta-analyses, particularly focusing on its effects on lipid profiles and other cardiometabolic indicators. The evidence quality is moderate, with systematic reviews and meta-analyses available, though study designs and outcomes can vary.
Benefits
Chlorella supplementation offers several evidence-based benefits, primarily in the realm of cardiovascular health and antioxidant support. A 2022 systematic review and dose-response meta-analysis of RCTs demonstrated that *Chlorella vulgaris* significantly reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), key markers for cardiovascular risk. However, it showed no significant effect on triglycerides (TG) or high-density lipoprotein cholesterol (HDL-C). While the effect sizes for lipid improvements are statistically significant, their clinical significance warrants further investigation. Benefits on lipid profiles typically emerge after 8-12 weeks of consistent supplementation. A 2025 meta-analysis indicated that Chlorella has a neutral effect on blood pressure and lipemia, differentiating it from Spirulina which showed a slight reduction in diastolic blood pressure. Additionally, Chlorella's rich vitamin E content contributes to its potential anti-inflammatory and antioxidant effects. Research on vitamin E, a major component of Chlorella, suggests it can reduce markers of subclinical inflammation, particularly with alpha-tocopherol forms at doses of 500 mg/day or more over at least 8 weeks. These benefits are most relevant for adults with dyslipidemia or other cardiometabolic risk factors.
How it works
Chlorella exerts its beneficial effects primarily through its rich content of antioxidants, including chlorophyll, various carotenoids, and vitamin E. These compounds work synergistically to combat oxidative stress and reduce inflammation within the body, processes that are fundamental to the development and progression of atherosclerosis and metabolic disorders. Furthermore, Chlorella may influence lipid metabolism by modulating pathways involved in cholesterol absorption and synthesis, although the precise molecular targets and mechanisms are still under active investigation. The efficacy of nutrient absorption from Chlorella, particularly for compounds like vitamin E, is influenced by its rigid cell wall. Therefore, some Chlorella formulations utilize broken cell walls to enhance the bioavailability of its beneficial components.
Side effects
Chlorella supplementation is generally considered safe, with a low incidence of adverse effects reported in clinical trials. The most commonly reported side effects, occurring in a small percentage of users (less than 5%), are mild gastrointestinal symptoms such as bloating or diarrhea. These symptoms are typically transient and can often be mitigated by taking Chlorella with food. There are no firmly established significant drug interactions or contraindications based on high-quality studies. However, due to limited specific safety data, individuals in special populations, such as pregnant or breastfeeding women, or those with autoimmune diseases, should exercise caution and consult a healthcare provider before initiating supplementation. While short-term use (up to 12 weeks) appears safe, long-term safety data beyond this period are currently limited. Users should be aware that the term "Chloressence" is likely a brand name, and the safety profile discussed here is based on studies of *Chlorella vulgaris*.
Dosage
Effective dosages of *Chlorella vulgaris* in clinical trials typically range from 1 to 5 grams per day, usually in powder or extract form. For optimal effects on lipid profiles, meta-analytic data suggest a dosage of approximately 2-3 grams daily. While there is no established maximum safe dose, dosages exceeding 5 grams per day are less extensively studied and may increase the likelihood of experiencing mild gastrointestinal side effects. The timing of Chlorella supplementation is flexible, as its absorption is not highly dependent on meal timing. However, taking it with food may help to minimize any potential mild gastrointestinal discomfort. It is important to note that formulations with broken cell walls are often recommended, as this processing method can significantly improve the bioavailability and absorption of Chlorella's beneficial nutrients.
FAQs
Is Chloressence the same as Chlorella?
The term "Chloressence" is likely a brand name for a Chlorella product. Our analysis is based on *Chlorella vulgaris*, the most scientifically studied species of Chlorella, which is the active ingredient in such products.
How long does it take to see benefits from Chlorella?
Improvements in lipid profiles, such as reductions in total and LDL cholesterol, typically become noticeable after 8 to 12 weeks of consistent daily Chlorella supplementation.
Is Chlorella safe for long-term use?
Current research supports the safety of Chlorella for up to 12 weeks of continuous use. Data on the safety of supplementation beyond this period are limited, so long-term users should consult a healthcare professional.
Does Chlorella lower blood pressure?
Based on current evidence, Chlorella appears to have a neutral effect on blood pressure. Unlike some other microalgae like Spirulina, it has not been shown to significantly reduce blood pressure.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35331862/ – This systematic review and dose-response meta-analysis of randomized controlled trials investigated the effects of *Chlorella vulgaris* supplementation on lipid profiles. It concluded that Chlorella significantly reduced total cholesterol and LDL-C but had no significant effect on triglycerides or HDL-C, suggesting a beneficial role in managing dyslipidemia.
- https://pubmed.ncbi.nlm.nih.gov/40289965/ – This meta-analysis compared the effects of *Chlorella* and Spirulina on cardiometabolic risk factors. It found that Chlorella had a neutral effect on blood pressure and lipemia, while Spirulina showed a modest reduction in diastolic blood pressure, highlighting differences in their physiological impacts.
- https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1035674/full – This umbrella review synthesized evidence on vitamin E supplementation and its effects on inflammation markers. It indicated that vitamin E, particularly alpha-tocopherol at doses of 500 mg/day or more for at least 8 weeks, can reduce markers of subclinical inflammation in adults, providing indirect support for Chlorella's anti-inflammatory potential due to its vitamin E content.
Supplements Containing Chloressence
Complete Whole Food Health Optimizer Natural Flavor
Sequel Vega
Complete Whole Food Health Optimizer Berry Flavor
Sequel Vega
Complete Whole Food Health Optimizer Berry Flavor
Sequel Vega
Complete Whole Food Health Optimizer Vanilla Chai Flavor
Sequel Vega