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Cissus Leaf Extract

Also known as: Veld grape, Devil's backbone, Asthisamharaka, *Cissus quadrangularis*

Overview

*Cissus quadrangularis* is a succulent vine found in tropical and subtropical areas, traditionally utilized for its health benefits. It contains a variety of bioactive compounds, including flavonoids, triterpenoids, and phytosterols, and is known for its potential in promoting bone health, aiding weight management, and providing antioxidant effects. Although existing research indicates benefits, it is considered to have a moderate level of research maturity, highlighting the need for further high-quality clinical studies to explore its efficacy and safety in more depth.

Benefits

The primary benefit of *Cissus quadrangularis* is its positive impact on bone health, with studies indicating it can help in the healing of bone fractures and may exert anti-osteoporotic effects. Additionally, it has shown significant potential for weight management, evidenced by a mean weight reduction of approximately 5.19 kg compared to placebo in clinical trials. The herb's antioxidant and anti-inflammatory properties further support its use in managing metabolic syndrome, making it particularly beneficial for individuals with obesity or related conditions. The evidence strength is moderate to high for bone and weight-related outcomes, although more research is required to establish definitive therapeutic protocols.

How it works

*Cissus quadrangularis* operates primarily through its antioxidant activity by scavenging free radicals and enhancing the activity of antioxidant enzymes. It also displays anti-inflammatory capabilities by inhibiting pro-inflammatory pathways. Importantly, it may influence skeletal system functions, improving bone healing and density, as well as metabolic pathways that contribute to weight management. Various compounds in Cissus, such as flavonoids and triterpenoids, can directly interact with cellular mechanisms, although detailed insights into absorption and bioavailability remain limited.

Side effects

Generally, *Cissus quadrangularis* is considered safe, with few studies reporting any significant adverse effects at common dosages. Data on specific side effects is lacking, with both common and uncommon side effects not well-documented. No rare side effects have been reported in the available literature. However, drug interactions are not thoroughly studied, so caution is advised when combining it with other medications. Pregnant or breastfeeding women should consult healthcare professionals before use, and there is little data on safety for children or individuals with severe health conditions. Overall, most adverse effects appear minimal, but ongoing monitoring for reactions is recommended.

Dosage

While a universally accepted minimum effective dose for *Cissus quadrangularis* is not well established, typical usage ranges from 300 mg to several grams per day, depending on the specific formulation and targeted application. Given the lack of defined maximum dosages, caution is advised when using higher doses. There are no specific timing recommendations, but taking it with meals may improve absorption. The supplement is available in varied forms, such as capsules and powders, allowing users to choose based on personal preference. Factors influencing absorption could include the presence of other nutrients in the diet, emphasizing the importance of a well-rounded intake.

FAQs

Is *Cissus quadrangularis* safe to use?

Generally regarded as safe, *Cissus quadrangularis* is free from serious adverse effects in studies, though interactions with other medications have not been thoroughly studied.

How long does it take to see results?

Results may vary, with noticeable benefits on bone health or weight management typically observed after several weeks to months of consistent use.

Can I take it with other supplements or medications?

While it is generally safe, it is advisable to consult a healthcare provider before combining *Cissus quadrangularis* with other supplements or medications.

What are the most common misconceptions about *Cissus quadrangularis*?

One common misconception is that it is a proven anabolic agent for bodybuilding. Current research does not support this claim.

What form is best for taking *Cissus quadrangularis*?

The best form depends on personal preference; it is available in capsules and powders, allowing for flexibility based on the desired method of ingestion.

Research Sources

https://www.microbiochemjournal.com/articles/ijcmbt-aid1016.php – This systematic review and meta-analysis of 1108 patients highlighted the significant benefits of *Cissus quadrangularis* combination products for weight reduction and improved lipid profile management compared to placebo, although it noted a need for more high-quality studies.
https://pubmed.ncbi.nlm.nih.gov/22976133/ – This review confirms that extracts of *Cissus quadrangularis* are safe and effective in aiding bone healing and managing weight. However, it emphasizes the necessity of well-controlled human studies for verifying health claims.
https://pubmed.ncbi.nlm.nih.gov/28165166/ – This literature review articulates the antioxidant, anti-inflammatory, and anti-diabetic properties of *Cissus quadrangularis*, suggesting these may contribute to its overall health benefits. It highlights the requirement for systematic reviews to assess efficacy accurately.
https://jmla.pitt.edu/ojs/jmla/article/download/246/1489 – The article provides a comprehensive overview of the pharmacological mechanisms and potential benefits of *Cissus quadrangularis*, underscoring the significance of further systematic exploration in clinical contexts.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5783 – This study illustrates the effects of *Cissus quadrangularis* in the context of safety and efficacy, recognizing the blend of various bioactive compounds that may contribute to its health claims, although it calls for more extensive human studies.