Citrus Bioflavinoids
Also known as: Hesperidin, Naringenin, Eriocitrin, Citrus Flavonoids, Citrus Bioflavonoids
Overview
Citrus bioflavonoids are a class of polyphenolic compounds extracted from citrus fruits including oranges, lemons, and grapefruits. They primarily consist of well-studied compounds such as hesperidin, naringenin, and eriocitrin. These bioflavonoids are recognized for their significant antioxidant characteristics, with extensive research hinting at their positive impact on cardiovascular health, lipid profile improvement, and glycemic control. Evidence suggests that they function effectively as free radical scavengers and modulate various biological pathways in the body. Despite moderate existing research, there is a consensus among experts for the need for additional studies to further explore their long-term effects and underlying mechanisms.
Benefits
Citrus bioflavonoids are linked to several notable health benefits: 1. Improved Endothelial Function: A systematic review found that citrus bioflavonoid supplementation can enhance flow-mediated vasodilation (FMD) by about 2.75%, supporting cardiovascular health. 2. Enhanced Lipid Profile: Meta-analyses indicate significant reductions in total cholesterol, LDL, and triglycerides, alongside increases in HDL levels. 3. Oxidative Stress Reduction: In patients with type 2 diabetes, these compounds may lower oxidative stress and improve metabolic markers. 4. Autoimmune Disease Management: While evidence remains inconclusive, some studies suggest possible benefits in autoimmune disease management. Populations with cardiovascular issues and type 2 diabetes appear to benefit the most, with evidence supporting clinical significance through solid effect sizes in various trials.
How it works
Citrus bioflavonoids mainly exert beneficial effects through their potent antioxidant properties, diminishing oxidative stress within the body by scavenging free radicals. Additionally, they positively influence lipid metabolism by modulating pathways involved in lipogenesis and beta-oxidation, leading to improved lipid profiles. Furthermore, they inhibit dipeptidyl peptidase-4 (DPP-4), which can enhance glycemic control by influencing insulin signaling pathways, collectively contributing to cardiovascular protection and metabolic health.
Side effects
Citrus bioflavonoids are generally considered safe, with minimal documented adverse effects. Common side effects (>5%) are limited, and significant adverse reactions from supplementation are rare. There are no consistently reported uncommon side effects (1-5%) or rare side effects (<1%) found in the literature. While potential drug interactions could arise, particularly with medications affecting blood sugar or lipids, specific interactions require more attention in future studies. Pregnant or breastfeeding women should consult healthcare providers due to insufficient safety data, and individuals with existing health conditions should exercise caution when considering supplementation.
Dosage
The effective dosage of citrus bioflavonoids typically ranges from 200 mg to 500 mg daily. The minimum effective dose is approximately 200 mg, which has been linked to benefits in endothelial function and lipid regulation. Optimal dosages in studies fluctuate from 19 mg to 560 mg, with 200-500 mg/day being the effective range. Although no maximum safe limit has been decisively established, doses up to 560 mg/day have shown a lack of significant adverse effects in clinical settings. Hesperidin-containing forms are common as they exhibit higher bioavailability; absorption of citrus bioflavonoids may be enhanced when combined with other dietary flavonoids, although further details are limited.
FAQs
Are citrus bioflavonoids safe?
Yes, citrus bioflavonoids are generally considered safe, though more long-term studies are needed regarding safety and interactions with medications.
How should I take citrus bioflavonoids?
Daily supplementation is recommended, with no specific timing; consistency in dosing is essential for potential benefits.
What benefits can I expect?
Citrus bioflavonoids may enhance endothelial function, improve lipid profiles, and reduce oxidative stress, particularly benefiting those with cardiovascular risk or type 2 diabetes.
Are all citrus bioflavonoid supplements the same?
No, bioavailability and effectiveness can vary significantly across supplements due to different formulations and dosages.
Supplements Containing Citrus Bioflavinoids
Ultimate Eye I
Dr. Stan Guberman
Multiple Cherry Flavor
Bluebonnet Rainforest Animalz
Multiple Cherry Flavor
Bluebonnet Rainforest Animalz
Multiple Orange Flavor
Bluebonnet Rainforest Animalz
Multiple
Bluebonnet Rainforest Animalz
Vitamin C Orange Flavor
Bluebonnet Rainforest Animalz
Women's One Multiple
AN Amazing Nutrition Amazing Formulas
Prenatal One Multiple
AN Amazing Nutrition Amazing Formulas
Men's One Multiple
AN Amazing Nutrition Amazing Formulas