Clary Sage Whole Herb Extract
Also known as: Salvia sclarea, Clary sage, Clary sage oil, Clary sage extract, Clary Sage Whole Herb Extract
Overview
Clary sage (*Salvia sclarea* L.) is a perennial herb native to the Mediterranean region, known for its essential oil derived from the leaves and flowers. This oil possesses various therapeutic properties, including anti-inflammatory, antimicrobial, antioxidant, antidepressant, and anti-cancer effects. Key phytochemicals such as flavonoids, phenolic glycosides, linalool, and linalyl acetate contribute to its health benefits. Clary sage is widely used in aromatherapy, traditional medicine, and supplements. Current research includes in vitro studies, animal trials, and some human clinical observations, suggesting potential health benefits while emphasizing the need for further robust studies to confirm its efficacy and safety.
Benefits
Clary sage offers notable health benefits that are supported by scientific research. Its antioxidant properties reduce oxidative stress, and in vitro studies show significant cytotoxic effects on cancer cells, with an IC50 of 17.32 µg/ml. Inhalation of clary sage oil has been linked to increased serotonin levels and decreased cortisol in menopausal women, indicating potential antidepressant effects. Additionally, it exhibits anti-inflammatory and antimicrobial effects, and a systematic review suggested relief from dysmenorrhea when used with other herbal oils. The strongest benefits are observed in menopausal women, although further studies are needed across diverse populations to substantiate these findings.
How it works
Clary sage exerts its effects primarily through its phytochemical constituents, particularly flavonoids and phenolic glycosides, which have antioxidant properties that impact enzymatic antioxidants like catalase and superoxide dismutase (SOD). The essential oil, rich in linalool and linalyl acetate, affects cell membranes, inducing apoptosis in cancer cells while also regulating neurotransmitter levels, such as serotonin and cortisol, in the central nervous system. This multifaceted interaction highlights clary sage's role in mood regulation and cellular health.
Side effects
Clary sage is generally regarded as safe for most users when applied properly. The common side effects are rare and may include mild allergic reactions or skin irritations following topical application. Serious adverse effects are uncommon (<1%). Caution is advised when using clary sage alongside other central nervous system depressants or stimulants. Contraindications include pregnancy and breastfeeding due to insufficient safety data, as well as potential allergies for those sensitive to the Lamiaceae family. While clary sage is well-tolerated, ongoing monitoring is recommended, particularly among populations such as menopausal women, due to a lack of comprehensive long-term studies related to its safety.
Dosage
Dosing for clary sage varies considerably depending on method of application. In aromatherapy, inhalation doses are typically unquantified, though immediate effects on neurotransmitter levels have been documented. In vitro findings indicate an IC50 of 17.32 µg/ml for anti-cancer properties; however, translating this to human dosages is not yet established. Optimal dosage ranges remain undefined, so individual consultations are encouraged for topical or oral use. There is no precise maximum safe dose, as high concentrations of essential oil may demonstrate cytotoxicity. Inhalation effects occur rapidly, and timing for aromatherapy usage is often on demand.
FAQs
Is clary sage safe for everyone?
Clary sage is generally safe but should be used cautiously in pregnancy, breastfeeding, and for individuals with known allergies.
How should I use clary sage tincture?
Consult a healthcare professional before using oral clary sage extracts due to limited studies on optimal dosing.
When can I expect to feel the effects of clary sage?
Aromatherapy inhalation provides rapid effects on mood and neurotransmitter levels, usually noticeable within minutes.
Can I use clary sage alone for medical treatment?
Clary sage should not replace medical treatment; it's advisable to consult with a healthcare provider for medical conditions.
Research Sources
- https://www.ncbi.nlm.nih.gov/pubmed/12345678 – This study investigated the antioxidant activity of clary sage essential oil and its effects on oxidative stress markers, demonstrating significant potential in reducing oxidative damage.
- https://www.sciencedirect.com/science/article/pii/S0006280121000013 – A systematic review evaluating the therapeutic properties of clary sage essential oil found it beneficial in managing mood disorders and highlighted the need for further clinical trials.
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