Cutch Tree Extract
Also known as: Cutch Tree Extract, Black Cutch, Catechu, Cutch, Acacia catechu
Overview
*Acacia catechu* is a thorny tree indigenous to India and other regions of Asia, known for its high content of polyphenolic compounds, particularly ellagic acid, rutin, and quercetin, which are extracted from the leaves, seeds, and heartwood. Traditionally, it has been utilized in Ayurvedic medicine for its multiple functional properties, including antioxidant and antiproliferative effects. In addition to its medicinal roles, it serves as a natural dye and tanning agent. Current research on *Acacia catechu* shows moderate maturity, revealing significant antioxidant potential and encouraging therapeutic properties primarily through in vitro and animal studies, while evidence from human clinical trials remains scarce.
Benefits
Studies indicate that *Acacia catechu* possesses considerable antioxidant activity, effectively scavenging ABTS radicals. Notably, it displays significant antiproliferative effects against cancer cell lines, particularly HepG2 cells, with maximum inhibition reaching 83% at concentrations of 10 µM. Animal models suggest that the extract may benefit individuals with osteoarthritis by minimizing bone damage and alleviating joint pain, especially when used in conjunction with other natural compounds. These findings are particularly applicable for populations affected by oxidative stress and certain cancer conditions, illustrating the extract's therapeutic potential.
How it works
The beneficial effects of *Acacia catechu* are primarily attributed to its polyphenolic compounds, which engage multiple biological pathways. These compounds scavenge free radicals, thereby reducing oxidative stress, and facilitate apoptosis in cancer cells. Moreover, the extract interacts with various cellular systems to inhibit cell proliferation and modulate molecular pathways associated with cancer and oxidative stress, providing a protective influence against several diseases.
Side effects
The safety profile of *Acacia catechu* remains inadequately defined in humans, reflecting its traditional utilization in Ayurvedic medicine. No prevalent (>5%) or notable (1-5%) side effects have been documented in the literature, and no rare (<1%) adverse effects have been reported. Information regarding drug interactions and contraindications is limited. Special caution should be taken by specific groups such as pregnant or breastfeeding women and individuals with allergies to *Acacia catechu*, given the insufficient data on safety in these populations.
Dosage
Establishing an appropriate dosage for *Acacia catechu* is challenging, as existing literature does not provide defined dosage ranges for human applications. In vitro studies indicate cytotoxic effects at concentrations as low as 0.1 µM; however, no minimum effective or maximum safe dose has been defined for human consumption. Typically, the extract is derived from leaves, seeds, or heartwood, with the methanolic extract of leaves being the most commonly studied. Currently, there are no specific recommendations regarding administration timing or factors affecting absorption.
FAQs
Is *Acacia catechu* safe for humans?
While traditionally used, comprehensive safety data in humans is lacking, and caution should be exercised.
How should I take *Acacia catechu*?
There are no specific recommendations for timing and administration available in the literature.
What results can I expect from using *Acacia catechu*?
Antioxidant and antiproliferative effects can be expected based on in vitro and animal studies.
Is *Acacia catechu* a substitute for medical treatments?
No, it should not be considered a substitute for medical treatment and should be used under healthcare guidance.
Research Sources
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140626/ – This study provides insights into the antioxidant activities of *Acacia catechu* and its polyphenolic components. It illustrates significant protective effects and potential therapeutic applications based on in vitro experiments.
- https://www.sciencedirect.com/science/article/pii/S0022459614006182 – This article discusses the antiproliferative effects of *Acacia catechu* on various cancer cell lines, highlighting mechanisms of action and the efficacy observed with different concentrations in laboratory settings.
Supplements Containing Cutch Tree Extract
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