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Cyanthox 30

Also known as: CyanthOx 30, Sea buckthorn proanthocyanidins extract, CyanthOx™30, Hippophae rhamnoides proanthocyanidins extract

Overview

CyanthOx 30 is a proprietary, water-soluble extract derived from the berries of the sea buckthorn plant (Hippophae rhamnoides). It is standardized to contain at least 30% proanthocyanidins and 20% bioflavonoids, including quercetin, kaempferol, and 3-methylquercetin. This plant-based supplement is primarily marketed for its potent antioxidant properties, anti-aging effects, and potential benefits for skin health, cardiovascular function, and blood circulation. In vitro studies suggest its antioxidant capacity is significantly higher than that of grape seed extract. While research is in early stages, preliminary human trials indicate its ability to stimulate circulating stem cells and enhance endogenous antioxidant enzyme activity. CyanthOx 30 is designed for easy absorption due to its thermal and pH stability, making it suitable for various applications.

Benefits

CyanthOx 30 shows promising benefits primarily related to its antioxidant and regenerative properties. A small, randomized, placebo-controlled, double-blinded, cross-over trial involving 12 participants demonstrated that a single 500 mg dose significantly stimulated circulating progenitor stem cells, endothelial stem cells, and mesenchymal stromal cells by over 40% within two hours. This suggests potential anti-aging and regenerative health benefits, though the clinical significance of this acute effect requires further investigation. The same study also reported improvements in antioxidant enzyme activity, with superoxide dismutase (SOD) increasing by 11% and glutathione (GSH) by 4%, alongside a 15% reduction in malondialdehyde (MDA), a marker of oxidative stress. These findings support its role in enhancing the body's natural antioxidant defenses. Secondary benefits, such as anti-inflammatory effects, improved skin health, and cardiovascular support, are hypothesized due to its stem cell stimulation and antioxidant properties, but direct clinical evidence for these specific outcomes is currently limited and requires more robust research.

How it works

CyanthOx 30 exerts its effects primarily through potent antioxidant activity and modulation of cellular regeneration. Its rich content of proanthocyanidins and bioflavonoids acts as a scavenger of reactive oxygen species, thereby reducing oxidative stress and protecting cells from damage. This antioxidant action is further supported by its ability to enhance the activity of endogenous antioxidant enzymes like superoxide dismutase (SOD) and glutathione (GSH), while simultaneously reducing lipid peroxidation (MDA). A key mechanism observed is the stimulation of circulating stem cells, including progenitor, endothelial, and mesenchymal stromal cells. While the exact pathways are still being elucidated, this stem cell mobilization is thought to contribute to regenerative processes and tissue repair. The water-soluble nature and stability of CyanthOx 30 are believed to facilitate its absorption and bioavailability within the body.

Side effects

Based on the available limited research, CyanthOx 30 appears to have a favorable safety profile. No adverse effects were reported in the small clinical trial conducted with a 500 mg dose, nor have any common, uncommon, or rare side effects been documented in anecdotal reports. However, due to the early stage of research and the small sample sizes in studies, the full spectrum of potential side effects is not yet established. There are no documented drug interactions, but caution is advised when combining with medications due to the limited data. Contraindications have not been established. Furthermore, there is no specific data available regarding its safety for special populations, including pregnant or lactating women, children, or individuals with pre-existing chronic diseases. Therefore, these populations should exercise caution and consult a healthcare professional before use.

Dosage

The optimal dosage range for CyanthOx 30 is generally recommended between 300 mg to 500 mg per day. This range corresponds to approximately 90-150 mg of sea buckthorn proanthocyanidins. A minimum effective dose of 187.5 mg per day has been suggested, though the proanthocyanidin content at this specific dose is not clearly specified. In the primary clinical trial, a single dose of 500 mg was used to observe acute effects. While acute effects on stem cell stimulation were observed within two hours of administration, the effects of chronic daily dosing are not yet fully understood or documented. The extract is a water-soluble powder, making it suitable for various applications, including beverages. No specific cofactors are identified as being required for its absorption, and its thermal and pH stability are believed to support good bioavailability. The maximum safe dose has not been formally established, but 500 mg has been used in studies without reported adverse effects.

FAQs

Is CyanthOx 30 safe for daily use?

Early evidence from small studies suggests it is safe at doses up to 500 mg daily, with no reported side effects. However, larger, long-term studies are needed to confirm its safety profile for daily, extended use.

How soon can benefits be expected?

Acute effects, such as stem cell stimulation, have been observed within two hours of a single dose. Longer-term benefits from consistent daily use are not yet fully documented.

Can it improve skin and cardiovascular health?

Potentially, through its antioxidant properties and ability to stimulate stem cells, which may support tissue regeneration. However, direct clinical evidence specifically for these benefits is preliminary and requires further research.

Is it better than grape seed extract?

In vitro studies indicate CyanthOx 30 has 8-9 times higher antioxidant capacity than grape seed extract. However, clinical superiority in human health outcomes has not been definitively proven.

Are there any known side effects?

No side effects have been reported in the available clinical studies or anecdotal reports. The safety profile appears favorable, but research is still limited.

Research Sources

https://www.puredia.com/product/cyanthox/clinical-trial – This source describes a randomized, placebo-controlled, double-blinded, cross-over trial involving 12 healthy adults. A single 500 mg dose of CyanthOx 30 increased circulating progenitor, endothelial, and mesenchymal stem cells by over 40% within 2 hours, and improved antioxidant enzyme activity. The study suggests potential anti-aging and regenerative benefits but is limited by its small sample size and short duration.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.914146/pdf – This is a narrative review focusing on the protective effects of sea buckthorn proanthocyanidins against oxidative stress, particularly in macrophages. It provides mechanistic insights into how sea buckthorn proanthocyanidins, the primary components of CyanthOx 30, exert antioxidant and anti-inflammatory effects, primarily based on preclinical data.
https://www.puredia.com/product/cyanthox – This source provides general information about CyanthOx 30, highlighting its composition, primary uses, and key characteristics, including its high proanthocyanidin content and reported antioxidant strength compared to grape seed extract. It serves as a product overview from the manufacturer.
https://thescienceofnutrition.me/2022/02/28/sea-buckthorn-the-next-generation-of-antioxidants/ – This article discusses sea buckthorn as a potent antioxidant source, referencing CyanthOx 30. It provides an overview of the ingredient's potential benefits, including its antioxidant capacity and stem cell stimulating properties, and mentions anecdotal reports of benefits for mild inflammatory or fatigue symptoms.
https://cellregen.us/pages/cyanthox – This source provides information on CyanthOx 30, emphasizing its role in stimulating stem cells and its antioxidant properties. It references the clinical trial findings regarding increased circulating stem cells and improvements in antioxidant markers, supporting its potential for regenerative health.