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Dimocarpus Longan Extract

Also known as: Longan, Dragon's Eye, Dimocarpus longan Lour., Dimocarpus longan

Overview

Dimocarpus longan, commonly known as longan or dragon's eye, is a subtropical fruit native to Asia, revered for its potential health benefits in traditional medicine. The fruit is rich in bioactive compounds, such as gallic acid, ellagic acid, and corilagin, which are believed to contribute to its medicinal properties. Longan extract has been studied for its anti-inflammatory, anti-cancer, and memory-enhancing effects; however, most research has been conducted in vitro or on animal models, with limited clinical data in humans. The extract is typically available as a dried form, used in dietary supplements aimed at promoting wellness and managing certain health conditions, particularly those related to glucose metabolism.

Benefits

Longan extract exhibits several evidence-based benefits, particularly in its anti-inflammatory and glucose-regulating properties. In animal studies, it has shown potential to improve insulin sensitivity and lower fasting blood glucose levels, making it especially relevant for individuals with type 2 diabetes. The anti-inflammatory effects are attributed to the suppression of the NF-κB and AP-1 pathways, thereby reducing inflammation. While these benefits are promising, the current limited data primarily stem from in vitro and animal studies, necessitating more human clinical trials to confirm efficacy and define specific populations that may benefit the most.

How it works

The biological mechanisms of Dimocarpus longan extract involve modulation of POMC/AgRP neuronal activities, which are crucial in appetite regulation, and suppression of pro-inflammatory pathways such as NF-κB and AP-1. These actions contribute to its potential benefits in regulating glucose metabolism and reducing inflammation. Interaction with the central nervous and immune systems has been noted, although detailed studies on absorption and bioavailability in humans remain lacking.

Side effects

The safety profile of Dimocarpus longan extract appears favorable, though human data is limited and many potential side effects are not well documented. Common side effects have not been reported, while uncommon or rare side effects remain unknown due to the absence of extensive human trials. Caution is advised for individuals managing diabetes, as the extract may interact with glucose-lowering medications. Additionally, pregnant or breastfeeding women are urged to consult healthcare providers before use, given the limited understanding of its safety in special populations. Overall, more clinical studies are needed to reinforce the safety profile and understand the risk factors associated with its consumption.

Dosage

Currently, no established dosage guidelines exist for the effective use of Dimocarpus longan extract in humans. In animal studies, dosages of around 50 mg/kg have been used, but corresponding human dosages remain speculative. Maximum safe doses have yet to be determined, and there are no specific timing considerations or absorption factors available in the literature. Users should consult healthcare professionals for personalized guidance, particularly in relation to supplementation and managing underlying health conditions.

FAQs

Is longan extract safe to use?

Generally considered safe, but human data is limited. Consult a healthcare provider before use, especially if you have diabetes.

What benefits can I expect from longan extract?

Potential benefits may include improved glucose regulation and reduced inflammation, especially for those with type 2 diabetes.

How should I take longan extract?

No specific dosing guidelines exist, so consult a healthcare provider for personalized recommendations based on individual health needs.

Does longan extract interact with any medications?

It may have interactions with diabetes medications due to its glucose-regulating effects; consult with a healthcare provider.

Can longan extract be used during pregnancy?

Limited data is available; pregnant or breastfeeding women should consult healthcare providers before use.

Research Sources

  • https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1143613/full – This study discusses the nutritional benefits and bioactive compounds found in Dimocarpus longan, highlighting its potential health benefits, particularly regarding glucose regulation and inflammation. However, it emphasizes the need for more human clinical trials.
  • https://pubmed.ncbi.nlm.nih.gov/26721218/ – This animal study demonstrated that longan extract could improve fasting blood glucose levels and enhance insulin sensitivity among diabetic mice, though the findings are limited by the model and lack of human applicability.
  • https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2021.670587/full – The article reviews potential anti-inflammatory properties of longan extract, showing its ability to inhibit NO production in macrophages through suppression of inflammatory pathways. The stronger implications in vivo remain to be confirmed.
  • https://www.researchgate.net/publication/340813257_Phytochemical_Constituents_and_Biological_Activities_of_Longan_Dimocarpus_longan_Lour_Fruit_A_Review – A comprehensive review of phytochemical constituents in longan fruit, detailing various biological activities, including antioxidant and anti-inflammatory effects. The review emphasizes the need for further research to establish clinical relevance.
  • https://www.researchgate.net/publication/388217197_Evaluation_of_the_anthelmintic_activity_of_ethanol_leaf_extract_of_Dimocarpus_longan_Lour_against_Taenia_solium – This study focuses on the anthelmintic properties of longan leaf extract. While not directly relevant to supplement benefits, it highlights ongoing research into longan's diverse biological activities.

Supplements Containing Dimocarpus Longan Extract

Gui Pi Wan by Min Shan
63

Gui Pi Wan

Min Shan

Score: 63/100