ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Dong Quai Root Extract

Also known as: Angelica sinensis, Dong Quai, Chinese Angelica

Overview

Dong Quai, scientifically known as *Angelica sinensis*, is a plant native to China, with its root widely used in traditional Chinese medicine. It is available in various forms, including root extracts, capsules, and teas. Historically, it has been used to address a range of health conditions, particularly those related to women's health, such as menstrual and menopausal symptoms. However, the scientific evidence supporting these uses is mixed, and more rigorous clinical trials are needed to confirm its efficacy. Dong Quai is thought to exert its effects through estrogenic activity, which can influence hormone-sensitive conditions. While some studies suggest potential benefits, others show inconclusive results, highlighting the need for caution and further research to establish clear efficacy and safety profiles.

Benefits

Some studies suggest that Dong Quai may improve outcomes for conditions like acute coronary syndrome and prevent radiation-induced dermatitis, although these findings are not universally supported. Limited evidence suggests potential benefits for women experiencing amenorrhea due to antipsychotic drugs. However, research indicates that Dong Quai is no more effective than a placebo in improving menopausal symptoms as measured by the Kupperman index. The effect sizes are generally not well-quantified, and the clinical significance of these benefits remains uncertain due to the mixed results and variability in study designs. More high-quality research is needed to confirm these benefits and determine the specific conditions and populations that may benefit most.

How it works

Dong Quai is believed to exert its effects through interactions with estrogen pathways, potentially influencing hormone-sensitive conditions. It can affect the reproductive and cardiovascular systems due to its potential estrogenic activity. While the exact molecular targets are not well-defined, it may influence estrogen receptors. The bioavailability of Dong Quai's active compounds is not well-studied, which adds uncertainty to understanding its precise mechanism of action. Further research is needed to fully elucidate the biological pathways and molecular targets involved in Dong Quai's effects.

Side effects

Dong Quai is generally considered safe when used appropriately, but caution is advised for individuals with hormone-sensitive cancers due to its estrogenic activity. Common side effects are not well-documented, but may include gastrointestinal issues. Potential uncommon side effects include allergic reactions or interactions with other medications. Due to its potential effects on blood clotting, Dong Quai may interact with blood thinners and other medications. Contraindications include hormone-sensitive cancers, pregnancy, and breastfeeding due to potential estrogenic effects. Caution is also advised for individuals with bleeding disorders or those taking anticoagulant medications. It is important to consult with a healthcare provider before using Dong Quai, especially if you have pre-existing health conditions or are taking other medications.

Dosage

The minimum effective dose of Dong Quai is not well-established, and optimal dosage ranges vary widely, typically used in traditional formulas. The maximum safe dose is not clearly defined. There are no specific timing recommendations for its use. Dong Quai is often used as a root extract in capsules or teas. The bioavailability of its active compounds is not well-studied, which can affect absorption. There are no documented required cofactors for its use. Due to the lack of clear dosage guidelines and potential safety concerns, it is important to consult with a healthcare provider before using Dong Quai.

FAQs

Who should avoid Dong Quai?

Individuals with hormone-sensitive conditions, such as certain cancers, and those who are pregnant or breastfeeding should avoid Dong Quai due to its potential estrogenic effects.

Can Dong Quai help with menopausal symptoms?

Evidence is mixed. Some believe it helps, but studies show it may be no more effective than a placebo for improving menopausal symptoms.

Are there any drug interactions with Dong Quai?

Yes, Dong Quai may interact with blood thinners and other medications due to its potential effects on blood clotting. Consult a healthcare provider before use.

How should I take Dong Quai?

Dong Quai is often used as a root extract in capsules or teas. However, consult a healthcare provider for personalized recommendations due to the lack of clear dosage guidelines.

Is Dong Quai safe for long-term use?

The long-term safety of Dong Quai is not well-established. It is important to use it cautiously and under the guidance of a healthcare provider.

Research Sources

  • https://www.mskcc.org/cancer-care/integrative-medicine/herbs/dong-quai – This resource from Memorial Sloan Kettering Cancer Center provides an overview of Dong Quai, including its uses, potential benefits, and safety considerations. It highlights the importance of caution for individuals with hormone-sensitive conditions due to Dong Quai's estrogenic activity. The resource emphasizes the need for further research to establish its efficacy and safety profile.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC6127017/ – This article discusses the potential benefits of Dong Quai for conditions like amenorrhea induced by antipsychotic drugs and some cardiovascular conditions. It notes that the evidence quality is mixed, and there is variability in study designs. The review suggests that while there may be some benefits, more rigorous research is needed to confirm these findings.
  • https://www.webmd.com/vitamins/ai/ingredientmono-936/dong-quai – WebMD provides information on Dong Quai, including its uses, potential side effects, and drug interactions. It highlights the importance of consulting with a healthcare provider before using Dong Quai, especially if you have pre-existing health conditions or are taking other medications. The resource also notes that the evidence supporting its benefits is mixed.
  • https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This review discusses the estrogenic activity of Dong Quai and the potential risks for hormone-sensitive cancers. It is based on in vitro and animal studies, suggesting that caution is warranted when using Dong Quai, particularly for individuals with a history of hormone-sensitive cancers. The review emphasizes the need for further research to fully understand the risks and benefits.
  • https://consensus.app/results/?q=Was+Dong+Quai+found+to+be+no+more+effective+than+a+placebo+in+improving+scores+on+the+Kupperman+index%3F&pro=on – This resource compiles research findings on Dong Quai's effectiveness in improving menopausal symptoms. It indicates that Dong Quai was found to be no more effective than a placebo in improving scores on the Kupperman index, a measure of menopausal symptoms. This suggests that the perceived benefits of Dong Quai for menopausal symptoms may be due to the placebo effect.

Supplements Containing Dong Quai Root Extract

The Cleaner Women's Formula by Century Systems
43

The Cleaner Women's Formula

Century Systems

Score: 43/100
Menopause Support by Pathway To Healing
70

Menopause Support

Pathway To Healing

Score: 70/100
MedCaps Menopause by XYMOGEN
68

MedCaps Menopause

XYMOGEN

Score: 68/100
Menopause Support by Vital Nutrients
83

Menopause Support

Vital Nutrients

Score: 83/100
Nature's Aphrodisiac For Women by Windmill Health Products
68

Nature's Aphrodisiac For Women

Windmill Health Products

Score: 68/100
Menopause Formula by Vitamer Laboratories
78

Menopause Formula

Vitamer Laboratories

Score: 78/100

Recommended Articles

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal Boosters & COVID-19 Antivirals: Safe Mix?

Herbal supplements may interact with COVID-19 antivirals, requiring careful consideration and further research.

Top Immune Support Ingredients: What Works?

Top Immune Support Ingredients: What Works?

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

Top Anti-Inflammatory Supplement Ingredients

Top Anti-Inflammatory Supplement Ingredients

Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.

Best Supplements for Cortisol Reduction: A Scientific Guide

Best Supplements for Cortisol Reduction: A Scientific Guide

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.