Durian Extract
Also known as: Durian, Durio, Durian fruit, Durio zibethinus
Overview
Durian, scientifically known as *Durio zibethinus*, is a tropical fruit native to Southeast Asia, renowned for its strong aroma and distinctive taste. The fruit is rich in carbohydrates, proteins, fibers, and vitamins B and C, as well as numerous bioactive compounds. Durian extract is principally used for its potent antioxidant and potential anticancer properties, making it a subject of interest in nutraceutical and cosmetic applications. The extract's high phenolic and flavonoid content contributes to its ability to combat oxidative stress. While emerging studies underline its health benefits, most research is limited to in vitro and animal studies, with a notable scarcity of human clinical trials backing its efficacy.
Benefits
Durian extract exhibits considerable antioxidant activity, demonstrating a total phenolic content of 116.55 mg GAE/g extract and total flavonoid content of 92.37 mg RE/g extract. Notably, it has shown up to 74% cytotoxicity against Chang liver cell lines at 100 μg/ml, suggesting potential anticancer effects. Secondary benefits include proposed anti-inflammatory and antimicrobial properties, yet these remain inadequately researched. Evidence predominantly stems from laboratory studies, with no conclusive human studies to establish specific population benefits or clinical significance. Overall, while in vitro results are promising, the lack of human trial data means that further research is essential for validating these findings.
How it works
The antioxidant effects of durian extract are primarily associated with its phenolic compounds, which have the capacity to scavenge free radicals and diminish oxidative stress. Additionally, there are potential interactions with biological pathways linked to cancer cell proliferation and inflammation, though the specific molecular targets remain undefined in human research. Overall bioavailability and absorption characteristics have not been thoroughly investigated, indicating a need for further detailed studies.
Side effects
Durian extract is generally regarded as safe when consumed as a whole fruit, but the safety profile for concentrated extracts in humans remains largely unestablished. No documented common, uncommon, or rare adverse effects have been reported in the available literature. There is also no known potential for drug interactions or specific contraindications associated with the extract. However, due to the lack of conclusive evidence, special populations, such as pregnant or breastfeeding women, are advised to consult with healthcare professionals prior to consumption due to insufficient data on safety.
Dosage
Currently, no established effective dosages exist for durian extract as a dietary supplement in humans. Optimal and maximum dosage levels have yet to be determined, and recommendations regarding timing and form-specific usage are also lacking. Factors influencing absorption have not been adequately studied, which further complicates dosage guidelines. Therefore, caution is advised until more definitive clinical research yields clear dosing parameters.
FAQs
Is durian extract safe to use?
While the whole fruit is generally safe, the safety of durian extract in humans needs further research for confirmation.
What benefits does durian extract provide?
Durian extract is noted for its antioxidant and potential anticancer effects, mainly observed in laboratory studies.
How should durian extract be taken?
Dosage and timing guidelines for durian extract are not established; more research is needed.
Can I use durian extract for cosmetic purposes?
Yes, some studies suggest durian extract's stability and lack of skin irritation make it promising for cosmetic applications.
Is there any clinical evidence supporting durian extract's health benefits?
Most evidence comes from in vitro studies; there is a significant need for clinical trials to validate these benefits in humans.
Research Sources
- https://jrespharm.com/uploads/pdf/pdf_MPJ_850.pdf – This in vitro study demonstrates durian extract's high antioxidant activity, particularly in ABTS and nitric oxide scavenging assays, while underscoring the absence of human clinical trials.
- https://pubmed.ncbi.nlm.nih.gov/25172686/ – A review focusing on the nutritional composition of durian highlights its rich bioactive compound profile and potential health benefits, albeit with limited proven research.
- https://www.mdpi.com/2079-9284/10/3/87 – This study explores the phytochemical aspects and potential cosmetic applications of durian extract, noting its stability and minimal skin irritation.
- https://www.mdpi.com/2311-7524/10/4/342 – This research discusses various attributes of durian extracts, but highlights that data on clinical applications and safety is still lacking.
- http://www.scielo.org.co/scielo.php?pid=S0121-81232021000200118&script=sci_arttext – The article summarizes the nutritional profile and potential health applications of durian, emphasizing that established therapeutic claims require further investigation.
Supplements Containing Durian Extract
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