Fadogia Agrestis Powder
Also known as: Fadogia agrestis, Black aphrodisiac, Bakin Gagai
Overview
Fadogia agrestis is a plant native to Nigeria, belonging to the Rubiaceae family. It has traditional uses as an aphrodisiac, for treating erectile dysfunction, and as a febrifuge. Current research is primarily based on animal studies, with no human trials available, limiting the quality of evidence. Animal studies suggest potential benefits such as increased testosterone levels and enhanced libido. However, the absence of human data and reliance on rodent models necessitate caution when extrapolating these findings to humans. Fadogia agrestis is typically available as a powder or extract. Further research is needed to determine its safety and efficacy in humans.
Benefits
Animal studies suggest that Fadogia agrestis may increase testosterone levels and enhance libido. A rodent study showed dose-dependent increases in testosterone (2-fold at 18 mg/kg, 3-fold at 50 mg/kg, and 6-fold at 100 mg/kg) and improved sexual performance metrics. Some evidence supports anti-inflammatory and analgesic properties, though these findings are preliminary. The observed benefits are primarily in male rodents, and the clinical significance in humans remains untested. Benefits in rodents were observed within 5 days of supplementation. The lack of human studies limits the strength of evidence for these benefits.
How it works
Fadogia agrestis is suspected to stimulate luteinizing hormone (LH) production, which in turn increases testosterone synthesis. This interaction primarily affects the reproductive and endocrine systems. Saponins present in the plant are thought to play a role in its effects. However, the exact mechanisms of action, including absorption and bioavailability, are not well characterized. Further research is needed to fully elucidate how Fadogia agrestis interacts with various biological pathways.
Side effects
The safety of Fadogia agrestis in humans is not established due to the lack of human studies. Potential side effects are largely unknown. Long-term rodent studies have noted potential cytotoxic effects, raising concerns about prolonged use. Drug interactions have not been studied, and contraindications are not established. Due to the lack of data, use in pregnant or breastfeeding women is not recommended. Comprehensive safety assessments in human populations are necessary to fully understand the risk profile of Fadogia agrestis.
Dosage
There is no established safe or effective dosage of Fadogia agrestis for humans. Dosage recommendations are speculative and extrapolated from rodent studies, potentially ranging from 1000-4500 mg/day. The maximum safe dose has not been determined. Timing considerations and form-specific recommendations are not established. Absorption factors are not well understood, and required cofactors have not been identified. Given the lack of human data, it is crucial to exercise caution and consult with a healthcare professional before considering Fadogia agrestis supplementation.
FAQs
What is the safe dosage for humans?
There is no established safe dosage for humans. Recommendations are extrapolated from animal studies and should not be considered definitive.
Are there any known side effects?
Side effects in humans are largely unknown due to the lack of human studies. Rodent studies suggest potential cytotoxic effects with long-term use.
How long does it take to see results?
In rodent studies, benefits were observed within 5 days of supplementation. However, the time course of effects in humans is unknown.
Is Fadogia agrestis safe for women?
Due to the lack of data, use in pregnant or breastfeeding women is not recommended. Safety in women has not been established.
What are the expected results?
Expected results are uncertain due to the lack of human studies. Animal studies suggest potential benefits in testosterone levels and libido.
Research Sources
- https://examine.com/supplements/fadogia-agrestis/ – Examine.com provides a general overview of Fadogia agrestis, summarizing available research on its effects on testosterone and libido. It highlights the limitations of current studies, primarily focusing on animal models, and emphasizes the need for human trials to confirm its efficacy and safety.
- https://pubmed.ncbi.nlm.nih.gov/30170324/ – This study investigates the effects of Fadogia agrestis on testicular function in rats. The findings suggest that Fadogia agrestis may increase testicular weight and enhance sperm parameters. However, the study is limited by its animal model and short duration, making it difficult to extrapolate the results to humans.
- https://advancedmolecularlabs.com/blogs/news/testosterone-booster-research-update-fodagia-agrestis-is-it-the-real-deal – This blog post discusses the potential of Fadogia agrestis as a testosterone booster, reviewing available research and highlighting its limitations. It emphasizes the need for more rigorous human studies to validate the claims made based on animal research.
- https://pubmed.ncbi.nlm.nih.gov/35969364/ – This study evaluates the effects of Fadogia agrestis stem extract on erectile dysfunction in rats. The results indicate that the extract may restore the NO/cGMP pathway, which is crucial for erectile function. While promising, the study lacks human data and broader applicability, limiting its clinical significance.
- https://pubmed.ncbi.nlm.nih.gov/16281088/ – This rodent study demonstrates significant increases in testosterone and improved sexual performance metrics with Fadogia agrestis supplementation. Limitations include the lack of human data and potential cytotoxic effects noted in longer studies, which need to be further investigated.