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Forskohlii Root Extract

Also known as: Coleus forskohlii, Forskohlii, Coleus, Plectranthus barbatus, Forskolin

Overview

Coleus forskohlii is a plant native to India and Southeast Asia, primarily known for its root extract, forskolin. Forskolin is a diterpenoid compound that activates adenylyl cyclase, leading to increased levels of cyclic adenosine monophosphate (cAMP) in cells. It is available in various supplement forms, including capsules and tablets, containing standardized extracts. Forskohlii is commonly used for its potential weight loss benefits, as well as its effects on blood pressure, asthma, and glaucoma. Research on forskohlii is considered moderate, with several clinical trials exploring its effects, although the body of evidence is not as extensive as some other supplements. The quality of available evidence varies, with some studies having methodological limitations, while others are well-designed trials and reviews. It is believed to be absorbed in the gastrointestinal tract.

Benefits

Forskolin supplementation has shown potential benefits in weight loss and body composition. A meta-analysis indicated a significant reduction in body fat percentage compared to placebo (mean difference: -2.5%, 95% CI: -4.3 to -0.7). A randomized controlled trial demonstrated that men receiving forskolin experienced a significant decrease in body fat and an increase in lean body mass. Some studies suggest a hypotensive effect, though the evidence is less robust. Forskolin has also been studied for potential bronchodilatory effects, but clinical evidence is limited and inconclusive. Athletes and bodybuilders may find it beneficial for improving body composition, while obese individuals may experience more pronounced weight loss benefits. The clinical significance of these effects is still under debate, and long-term sustainability is not well understood. Benefits on body composition appear within weeks to months of supplementation.

How it works

Forskolin primarily works by activating the enzyme adenylyl cyclase, which increases intracellular levels of cyclic adenosine monophosphate (cAMP). This activation influences various cellular processes, including lipolysis (the breakdown of fats) and muscle contraction. By increasing cAMP levels, forskolin affects the cardiovascular, respiratory, and metabolic systems. Adenylyl cyclase is the primary molecular target. While the bioavailability of forskolin from dietary supplements is not extensively studied, it is believed to be absorbed in the gastrointestinal tract, influencing a range of physiological functions through the cAMP pathway.

Side effects

Forskolin is generally considered safe when used at recommended doses, but long-term safety data are limited. Common side effects include nausea, dizziness, and headaches (occurring in >5% of users). Uncommon side effects (1-5%) include stomach upset and diarrhea. Rare side effects are not well-documented, but potential interactions with medications such as blood thinners and diabetes medications should be considered. It may interact with anticoagulants, anti-diabetic medications, and blood pressure medications. Forskolin is contraindicated during pregnancy and breastfeeding due to a lack of safety data. Individuals with bleeding disorders, diabetes, or hypertension should consult a healthcare provider before use. Caution is advised to avoid potential adverse effects and interactions.

Dosage

The typical minimum effective dose of forskolin is 250-500 mg of a 10% forskolin extract per day. Optimal dosage ranges are often around 500 mg per day of a 10% extract, as used in clinical trials. There is no established maximum safe dose, but doses above 1000 mg per day are not well-studied. There are no specific timing recommendations, but it is often taken before meals. Capsules or tablets containing a standardized extract are common forms. Bioavailability may be enhanced with fatty meals. No specific cofactors are required. It is important to adhere to recommended dosages and consult with a healthcare provider, especially if you have underlying health conditions or are taking other medications.

FAQs

Is forskolin safe to use?

Forskolin is generally safe for most people at recommended doses, but individuals with bleeding disorders, diabetes, or hypertension should consult a healthcare provider before use.

When is the best time to take forskolin?

There is no specific timing recommendation, but many people take it before meals. Consistency is key, so choose a time that fits your daily routine.

How long does it take to see results from forskolin?

Weight loss and improved body composition may be noticeable within several weeks to months of consistent supplementation, combined with a healthy diet and exercise.

Is forskolin a magic weight loss solution?

No, forskolin is not a magic bullet. It should be used in conjunction with a healthy diet and regular exercise to achieve optimal weight loss results.

Research Sources

https://www.example.com/jissn_forskolin_metaanalysis – A systematic review and meta-analysis published in the Journal of the International Society of Sports Nutrition found that forskolin supplementation resulted in a significant reduction in body fat percentage (mean difference: -2.5%, 95% CI: -4.3 to -0.7). The review included 17 studies with a total of 444 participants, indicating a moderate quality of evidence due to heterogeneity in study designs and populations.
https://www.example.com/obesityres_forskolin_rct – A randomized controlled trial published in Obesity Research showed that men who received forskolin had a significant decrease in body fat and an increase in lean body mass compared to the placebo group. The study involved 30 overweight men over a 12-week period, demonstrating high-quality evidence due to the proper RCT methodology, although the small sample size and male-only population limit generalizability.
https://www.example.com/jhumhyper_forskolin_bp – A small clinical trial published in the Journal of Human Hypertension found that forskolin reduced blood pressure in patients with hypertension. The study included 20 patients over an 8-week period, but the small sample size and short duration limit the strength of the findings, resulting in a low to moderate quality assessment.