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D-Serine

Also known as: Glycine, Sarcosine, Phosphatidylserine

Overview

D-Serine is an amino acid found in the brain. Derived from glycine, d-serine is a neuromodulator, meaning it regulates the activities of neurons. D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced N-methyl-D-aspartate (NMDA) signaling, which includes cocaine dependence and schizophrenia. D-Serine’s effect on schizophrenia is well researched, and though it shows promise, it is also unreliable, since d-serine does not always reach the blood after supplementation. Sarcosine may be a more reliable treatment. D-Serine is a coagonist at NDMA receptors, which means it improves the effects of other compounds that bind with the receptor. These compounds include glutamate and NMDA itself. D-Serine is often categorized as a nootropic.

Benefits

D-Serine acts as a coagonist at NMDA receptors in the brain. This means that it enhances the effects of other neurotransmitters, such as glutamate, that bind to these receptors. By doing so, D-Serine plays a crucial role in modulating synaptic transmission and plasticity, which are essential for cognitive functions such as learning and memory.

How it works

D-Serine supplementation has been associated with several benefits, particularly in the context of mental health. It may help improve cognitive function, particularly in individuals suffering from schizophrenia, by enhancing NMDA receptor activity. Additionally, it has shown potential in reducing symptoms of cognitive decline and may aid in the treatment of conditions characterized by NMDA receptor dysfunction, such as cocaine dependence.

Side effects

The usual dose used in D-serine studies is 30 mg/kg of bodyweight. This correlates to an approximate dose range of 2,045 – 2,727 mg for people between 150 and 200 lbs. This dose appears to be the minimal effective dose for improving cognition in people suffering from a variety of diseases. Preliminary evidence suggests that doubling or quadrupling the dose to 60 mg/kg and 120 mg/kg, respectively, will cause additional benefits for people suffering from schizophrenia.

Dosage

D-Serine is generally considered safe when used at recommended dosages. However, potential side effects may include gastrointestinal discomfort, headache, and dizziness. There are safety concerns regarding its use in individuals with certain medical conditions, particularly those with kidney issues, as D-serine is processed by the kidneys. It is advisable to consult a healthcare provider before starting supplementation, especially for individuals with pre-existing health conditions.