Glycyrrhiza Uralensis Root Extract
Also known as: Licorice root, Chinese licorice, Glycyrrhiza uralensis
Overview
*Glycyrrhiza uralensis* is a perennial plant native to Asia, valued for its roots, which contain bioactive compounds like glycyrrhizin and liquiritigenin. Commonly utilized in traditional herbal medicine, this extract is particularly renowned for its anti-inflammatory, antioxidant, and antimicrobial properties. Its applications span the treatment of liver diseases and gastrointestinal disorders, with growing interest in its broader therapeutic potential. Although research on *Glycyrrhiza uralensis* is increasing, the quality of available evidence varies; while some studies are robust, many more are needed to fully elucidate its efficacy and safety in different populations.
Benefits
Evidence supports several benefits of *Glycyrrhiza uralensis*, primarily for liver health, where glycyrrhizin effectively reduces fibrosis markers associated with liver damage by inhibiting the TGF-β1 signaling pathway. It has shown significant antioxidant properties, particularly from licorice sprouts, which lessen lipid levels and improve antioxidant enzyme activities. These effects suggest that it is especially beneficial for individuals with liver conditions or those seeking enhanced antioxidant support. Variability in benefit timing indicates that consistent use over weeks or months may be necessary to observe significant effects.
How it works
The primary mechanism of action of *Glycyrrhiza uralensis* involves the inhibition of 11β-hydroxysteroid dehydrogenase (11β-HSD), producing corticosteroid-like effects. This interaction reduces liver fibrosis by attenuating the TGF-β1 signaling pathway. Glycyrrhizin and its derivatives engage with multiple biological pathways, impacting the liver and gastrointestinal systems while accounting for cardiovascular effects due to mineralocorticoid-like activity.
Side effects
While generally regarded as safe when used properly, chronic consumption of *Glycyrrhiza uralensis* can lead to notable side effects including hypokalemia and hypertension due to its mineralocorticoid-like properties. Less common effects may include edema and headaches. Rare instances of severe hypokalemia could result in muscle weakness or cardiac complications. Care should be taken in individuals taking diuretics or corticosteroids, as these medications may interact negatively. Contraindications include pregnancy and existing conditions such as severe hypertension or heart failure. Caution is also warranted in patients with kidney diseases.
Dosage
Recommended dosages for *Glycyrrhiza uralensis* typically range from 1 to 5 grams of dried root per day, although higher amounts may be necessary for certain liver health indications with a maximum advised limit of 10 grams daily. It is advisable to take these dosages consistently and at specific times of the day to ensure optimal effects. Common forms include capsules and teas, and bioavailability may vary based on preparation. Currently, there are no identified specific cofactors needed for absorption.
FAQs
How long does it take to see benefits?
Benefits may be noticeable after several weeks of consistent use.
Is it safe for long-term use?
Chronic use can lead to side effects like hypertension; monitoring is recommended.
Can it interact with other medications?
Yes, particularly with diuretics and corticosteroids.
Research Sources
- https://www.liebertpub.com/doi/10.1089/jmf.2019.4459 – This systematic review and meta-analysis investigates the efficacy of glycyrrhizic acid on liver fibrosis, revealing significant reductions in markers such as TGF-β1 and Smad proteins, suggesting its potential to reverse fibrosis. Challenges included study variability and a limited number of quality studies.
- https://pubmed.ncbi.nlm.nih.gov/38527575/ – In vitro and in vivo studies highlighted licorice sprouts' antioxidant properties, demonstrating no cytotoxicity and significant reductions in lipid levels alongside enhancements in antioxidant enzyme activities. The study's rigorous design underscores the importance of its findings within a molecular context.
- https://www.scielo.br/j/cta/a/8BkTCwd3yPd43tqdpQ3f9NQ/ – This review explores the pharmacological properties of licorice root, emphasizing its anti-inflammatory, antioxidative, and antimicrobial effects, and potential therapeutic applications, although highlighted limitations pertain to the lack of specific experimental data.