Grape Whole Fruit Extract
Also known as: Vitis vinifera Extract, Grape Seed Extract, Whole Grape Extract, Grape Whole Fruit Extract
Overview
Grape whole fruit extract is derived from the entire grape fruit of the vine species *Vitis vinifera*, encompassing the skin, seeds, and pulp. This extract is notably abundant in polyphenolic compounds, including flavonoids and proanthocyanidins, which confer potent antioxidant properties. Its primary applications include supporting cardiovascular health, mitigating inflammation, and enhancing lipid profiles. The efficacy of grape whole fruit extract is substantiated by a wealth of randomized controlled trials and systematic reviews, affirming its role in promoting overall health, particularly in individuals with cardiovascular diseases. Rich in antioxidants, it plays a vital role in combating oxidative stress, making it a valuable dietary supplement in both clinical and general populations.
Benefits
Grape whole fruit extract is recognized for its numerous evidence-based benefits. Notable improvements include reductions in total cholesterol (-6.196 mg/dL), LDL cholesterol (-4.964 mg/dL), and triglycerides (-7.641 mg/dL), as demonstrated in various meta-analyses. Additionally, it significantly lowers inflammation markers, such as C-reactive protein (CRP) by -0.229 mg/dL, and enhances glycemic control with decreases in fasting plasma glucose (-2.01 mg/dL). The most substantial effects have been observed in patients with pre-existing clinical conditions, particularly those taking doses exceeding 500 mg/day for a minimum of 12 weeks. Overall, the evidence supports grape whole fruit extract's benefits for cardiovascular health and oxidative stress management.
How it works
The beneficial effects of grape whole fruit extract are largely due to its rich polyphenolic content, which exhibits strong antioxidant activities and enhances endothelial function. These polyphenols effectively scavenge free radicals and diminish oxidative stress, crucial for maintaining cardiovascular health. The extract also inhibits the activity of the nuclear factor kappa B (NF-κB), a key inflammatory regulator, thereby reducing levels of inflammatory markers such as CRP. This multifaceted interaction positively influences cardiovascular and metabolic systems, aiding in lipid profile regulation, blood pressure maintenance, and glycemic control.
Side effects
Grape whole fruit extract is typically regarded as safe when consumed at recommended dosages, with most studies reporting no common side effects exceeding 5%. However, some users may experience gastrointestinal discomfort, including nausea or diarrhea, which are considered uncommon adverse effects (1-5%). Rare or serious side effects are significantly less than 1% and not frequently documented. Caution is advised for individuals on anticoagulant therapy due to the extract's antioxidant properties. Those with allergies to grapes should avoid this supplement, and pregnant or breastfeeding women are urged to consult healthcare professionals to ensure safety as data on these populations is limited.
Dosage
For optimal health benefits, a minimum effective dose of around 500 mg/day of grape polyphenols is recommended. More pronounced effects are typically noted at doses greater than 500 mg/day, especially over intervention periods of 12 weeks or longer. While no maximum safe dose has been firmly established, quantities exceeding 1000 mg/day are less studied and warrant caution. Consistent daily intake is encouraged, though specific timing does not significantly impact efficacy. Grape whole fruit extract is commonly available in capsule or tablet forms containing standardized extracts, and bioavailability may be improved when taken with meals rich in fats.
FAQs
Is grape whole fruit extract safe?
Generally, grape whole fruit extract is considered safe; however, consult healthcare providers if you have existing health conditions or are on medication.
When should I take grape whole fruit extract?
There is no specific timing requirement, but consistent daily intake is recommended for optimal results.
How long until I see results?
Improvements in lipid profiles and CRP levels are typically observed within 12 weeks of consistent supplementation.
Can grape extract replace my medication?
It should not be viewed as a substitute for medical treatment, but can complement prescribed therapies under healthcare guidance.
Research Sources
- https://www.ncbi.nlm.nih.gov/pubmed/29486214 – This meta-analysis evaluates the effects of grape polyphenols on cardiovascular risk factors, concluding that the supplementation significantly reduces LDL cholesterol and triglycerides while improving inflammatory markers among various clinical populations.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516243/ – This systematic review presents evidence on dietary polyphenols, including grape extracts, highlighting their antioxidant effects and potential to improve markers of cardiovascular health through multiple mechanisms and in various chronic diseases.
Supplements Containing Grape Whole Fruit Extract
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