Hydrangea
Also known as: Hydrangea macrophylla, Hydrangea serrata, Hydrangea, Bigleaf Hydrangea, Mountain Hydrangea
Overview
Hydrangea is a genus of flowering plants, with *Hydrangea macrophylla* and *Hydrangea serrata* being the most commonly studied species. Native to Asia and North America, it has traditional uses for urinary tract issues and is currently being researched for anti-aging and weight management effects. The plant contains compounds like hydrangenol and dihydroisocoumarins, which are believed to contribute to its biological activities. Research on hydrangea is still emerging, with a growing number of clinical trials but a need for more systematic reviews. The quality of available evidence is variable, with some well-designed randomized controlled trials (RCTs) but a lack of comprehensive meta-analyses. Hydrangea supplements are available in various forms, including oral capsules and tablets, and are often derived from leaf extracts.
Benefits
*Hydrangea serrata* leaf extract has demonstrated benefits for skin health and weight management. A randomized, double-blind, placebo-controlled trial showed significant reductions in skin wrinkles and improvements in hydration and elasticity in human participants. Another RCT indicated that *Hydrangea serrata* extract supplementation led to reductions in body weight, body fat mass, and BMI in overweight individuals. These benefits were observed over a 12-week supplementation period. While potential anti-inflammatory and antioxidant effects have been suggested, more research is needed to confirm these benefits. Currently, the documented benefits are primarily observed in adults for skin health and weight management.
How it works
The active compounds in hydrangea, such as hydrangenol, are believed to interact with skin and metabolic pathways, influencing collagen synthesis and fat metabolism. While the exact mechanisms are not fully understood, it is thought that these compounds may interact with the integumentary and metabolic systems. The specific molecular targets are not well-defined, but compounds like hydrangenol may influence cellular processes related to aging and metabolism. Limited data is available on the absorption and bioavailability of hydrangea compounds in humans, which is an area requiring further investigation to fully elucidate its mechanism of action.
Side effects
Hydrangea is generally considered safe based on available clinical trials, with no significant adverse effects reported. Common, uncommon, and rare side effects have not been documented in clinical trials. However, potential interactions with other medications are not well-studied, and caution may be advised in individuals with certain medical conditions or during pregnancy/lactation due to a lack of comprehensive data. Special population considerations, such as use in children or individuals with severe health conditions, are limited. It is important to consult with a healthcare provider before starting hydrangea supplementation, especially if taking other medications or having pre-existing health conditions, to ensure safety and avoid potential interactions.
Dosage
For *Hydrangea serrata* leaf extract, doses of 300 mg to 600 mg per day have been studied. Currently, 600 mg per day appears to be the most effective dose for weight management and skin health benefits, based on available research. The maximum safe dose has not been definitively established, but doses up to 600 mg per day have been used without reported adverse effects in clinical trials. Daily supplementation is typical, and oral capsules or tablets are the commonly used forms. More research is needed to understand the absorption factors and required cofactors for optimal utilization of hydrangea supplements.
FAQs
Is hydrangea supplement safe?
Hydrangea supplements are generally considered safe, with no significant side effects reported in clinical trials. However, it's important to consult with a healthcare provider before use, especially if you have existing health conditions or are taking other medications.
How should I take hydrangea supplements?
Typically, hydrangea supplements are taken once daily. Follow the dosage instructions on the product label or as directed by your healthcare provider. Consistency is key for observing potential benefits over several weeks.
What are the expected results from taking hydrangea supplements?
Improvements in skin health and body composition may be observed over several weeks with consistent use. However, hydrangea is not a cure-all and should be used as part of a balanced lifestyle, including a healthy diet and regular exercise.
Are there any drug interactions with hydrangea supplements?
Potential interactions with other medications are not well-studied. Consult with your healthcare provider or pharmacist to ensure there are no contraindications with any medications you are currently taking.
Can pregnant or breastfeeding women take hydrangea supplements?
Due to limited data on the use of hydrangea supplements in pregnant or breastfeeding women, caution is advised. It is best to consult with a healthcare provider before use to ensure safety for both mother and child.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8622367/ – This randomized, double-blind, placebo-controlled trial with 151 participants found that *Hydrangea serrata* leaf extract significantly improved skin wrinkles, hydration, and elasticity after 12 weeks. The study suggests that hydrangea extract may have potential benefits for skin health, highlighting its role in improving skin parameters.
- https://pubmed.ncbi.nlm.nih.gov/32481760/ – This randomized, double-blind, placebo-controlled trial demonstrated that *Hydrangea serrata* extract reduced body weight, body fat mass, and BMI in overweight individuals over a 12-week period. The findings indicate that hydrangea extract may be a beneficial supplement for weight management in overweight or obese individuals.
- https://www.mdpi.com/2072-6643/14/1/208 – This article discusses the potential health benefits of various plant extracts, including Hydrangea. It highlights the antioxidant and anti-inflammatory properties of certain compounds found in Hydrangea, suggesting their potential role in promoting overall health and well-being.
- https://www.healthline.com/nutrition/hydrangea-root – This article provides a general overview of hydrangea root, discussing its traditional uses and potential health benefits. It mentions that hydrangea has been used for urinary tract issues and highlights the need for more research to confirm its efficacy and safety.
- https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2024.1412189/full – This research article explores the various applications of plants in traditional medicine, including Hydrangea. It discusses the phytochemical composition of Hydrangea and its potential therapeutic properties, emphasizing the need for further scientific investigation to validate its traditional uses.
