Isatis Root Extract
Also known as: Isatis tinctoria, Isatis indigotica, Dai Muko, Ban Lan Gen, Isatis Root Extract
Overview
Isatis root extract is derived from two key medicinal plants, Isatis tinctoria and Isatis indigotica, both prominently used in Traditional Chinese Medicine (TCM) and Ayurveda. This extract is particularly recognized for its high levels of indirubin, a bioactive compound linked to various therapeutic effects. Traditionally, Isatis root has been employed to treat respiratory ailments, such as bronchitis and chest congestion, along with its proposed antiviral properties. Recent preclinical studies have highlighted its potential efficacy in treating radiation-induced mucositis, a common complication in cancer patients undergoing radiotherapy. While the extract presents promising therapeutic avenues, most studies remain at the preclinical stage, indicating a critical need for well-designed clinical trials to validate its effectiveness and safety across diverse patient groups.
Benefits
Isatis root extract shows promise mainly in alleviating radiation-induced mucositis among patients with head and neck cancers, with some randomized controlled trials supporting this application. In vitro studies and laboratory research indicate its anti-inflammatory and immune-modulating effects, suggesting potential benefits for various inflammatory conditions. Animal research suggests that Isatis root extract may protect against tissue injuries by influencing inflammatory pathways. However, the existing research is primarily of low quality, evidencing a considerable gap in rigorous clinical studies needed to confirm its effectiveness in larger, more heterogeneous populations.
How it works
The therapeutic effects of Isatis root extract are primarily attributed to indirubin, which inhibits cyclin-dependent kinases (CDKs), resulting in G2/M phase cell cycle arrest—an action indicative of its potential anticancer properties. Indirubin also exhibits anti-inflammatory effects by inhibiting key enzymes, such as cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), which are crucial for generating inflammatory mediators. Most published findings stem from in vitro experiments, emphasizing the urgent need for further investigation into indirubin's bioavailability and the efficacy in human subjects.
Side effects
The safety profile of Isatis root extract is still not fully established due to the limited quantity of clinical studies involving human subjects. Generally, oral use is perceived as low-risk; however, some uncommon adverse effects have been reported. Individuals taking medications that are processed by the CYP450 3A4 enzyme system should exercise caution due to potential interactions identified in laboratory contexts. Severe side effects tend to be rare, yet the lack of extensive safety assessments warrants careful consideration of Isatis root extract, especially among vulnerable populations, including pregnant women and children. It is advisable for users to consult healthcare professionals prior to commencing supplementation to assess possible drug interactions and other contraindications.
Dosage
Currently, no official dosage guidelines for Isatis root extract have been established, highlighting a significant gap within clinical research on this extract. Most existing studies focus on extract solutions without providing specific dosing or administration protocols. The variability in absorption characteristics further complicates practical usage. Individuals interested in incorporating Isatis root extract into their regimen should seek personalized recommendations from healthcare providers to determine suitable dosages while also being aware of the risks associated with excessive consumption.
FAQs
Is isatis root safe for everyone?
Isatis root safety is not well established. Caution is advised, particularly for those on specific medications or in special populations.
How should isatis root be taken?
There are no standardized guidelines for timing or administration due to limited human studies, so professional consultation is recommended.
Can isatis root help with cancer treatment?
While some lab studies suggest potential benefits, isatis root is not proven as a standalone cancer treatment in humans.
What results can I expect from isatis root supplementation?
Current evidence is insufficient to guarantee specific health benefits; further studies are needed to validate any claims.
Supplements Containing Isatis Root Extract
Wellness Formula
Source Naturals Wellness
Wellness Formula
Source Naturals Wellness
Wellness Formula
Source Naturals Wellness
Wellness Formula
Source Naturals Wellness
Wellness Formula
Source Naturals Wellness
Isatis
Herbalist & Alchemist
David Winston's VX Immune Support
Herbalist & Alchemist
Echinacea-Goldenseal With Olive Leaf
Planetary Herbals
Andrographis Respiratory Wellness
Planetary Herbals
Andrographis Respiratory Wellness
Planetary Herbals
Andrographis Respiratory Wellness
Planetary Herbals
Yin Chiao-Echinacea Complex
Planetary Herbals
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