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Khella Seed Extract

Also known as: Khella, Khellin, Visnagin, Khella Seed Extract, Ammi visnaga Seed Extract

Overview

Khella, derived from the seeds of the *Ammi visnaga* plant, is a Mediterranean herb traditionally used for various health conditions, particularly respiratory disorders like asthma. The extract is rich in active furoquinoline alkaloids such as khellin and visnagin, which are thought to confer anti-inflammatory and antispasmodic properties. Historically used in folk medicine, khella's modern applications lack a robust scientific foundation, with most evidence being anecdotal. Despite some preliminary studies suggesting possible benefits for respiratory and cardiovascular health, the evidence remains insufficient and necessitates further investigation to establish efficacy and safety more conclusively.

Benefits

Khella has been primarily used for managing respiratory conditions; however, the current evidence supporting its effectiveness is inconclusive and derived from studies of low quality. Preliminary findings suggest potential anti-inflammatory and cardiovascular benefits, yet no specific populations have been identified that derive significant advantages from its use. The overall impacts on health remain inadequately documented, emphasizing the need for high-quality clinical trials to better understand its therapeutic potential.

How it works

The main components of khella, khellin and visnagin, are believed to promote smooth muscle relaxation, particularly in the respiratory tract, which may help alleviate spasms. They are also thought to hold anti-inflammatory attributes that could positively influence cardiovascular health. However, the precise molecular mechanisms and biological pathways involving these compounds in humans require further clarification through dedicated research efforts.

Side effects

Khella is associated with several adverse effects, the most common being nausea and vomiting, which appear in a notable number of cases. Other adverse effects, albeit less frequent, include elevated liver enzymes (transaminitis) and, in rare instances, acute kidney injury. Individuals with pre-existing liver or kidney conditions should avoid khella, as interactions with medications are not well-studied. Additionally, there are concerns about phototoxicity and dermatitis risks, particularly in vulnerable populations, including pregnant and breastfeeding women. Consequently, its consumption should be approached with caution.

Dosage

Currently, there is no established minimum effective dose for khella; traditional uses often involve consuming boiled seeds or extracts. The lack of standardized dosages raises safety concerns due to potential toxicity associated with high intake levels. Furthermore, there are no provided timing recommendations for khella usage, meaning individuals should approach using khella supplements with caution, considering their own health status and potential absorption variations.

FAQs

What should I consider before using khella?

Use khella cautiously due to possible side effects and limited safety data. Those with liver or kidney issues should avoid it without medical supervision.

Is there a specific time to take khella?

There are no specific timing recommendations for khella consumption.

What benefits can I expect from khella?

Benefits are not well documented, and expectations should be tempered by limited evidence supporting its effectiveness.

Are there any misconceptions about khella I should be aware of?

Khella is not a proven treatment for enhancing kidney function and may pose risks for kidney injury.