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Kidney Bean Extract

Also known as: white kidney bean, kidney bean extract, Phaseolus vulgaris

Overview

White kidney bean extract is derived from the common white kidney bean (*Phaseolus vulgaris*), notable for its high content of α-amylase inhibitors. These proteins impede the action of α-amylase, an enzyme responsible for breaking down carbohydrates. By limiting carbohydrate digestion and absorption, this extract is primarily marketed as a weight-loss supplement while also aimed at enhancing metabolic health. The key components found in this extract include proteins, carbohydrates, and fats, with α-amylase inhibitory activity reported to range between 1,360 and 5,777 U/g. Despite the existence of randomized controlled trials (RCTs) and systematic reviews, the research presents mixed results regarding its effectiveness, indicating a need for further exploration in different populations and settings.

Benefits

Research indicates that white kidney bean extract can provide several potential benefits: 1. Weight Loss: Studies suggest a small, statistically significant reduction in body fat, with a meta-analysis showing a mean difference of -1.86 kg in body fat reduction compared to placebo groups. However, the evidence remains mixed regarding overall body weight improvements. 2. Metabolic Health: The extract may support metabolic health via its mechanism of inhibiting carbohydrate absorption. Though some studies suggest beneficial metabolic changes, the inconsistencies in findings warrant cautious interpretation. 3. Population Specificity: Benefits appear most evident in overweight or obese individuals, yet general recommendations for the broader population remain unsupported.

How it works

White kidney bean extract functions primarily through the inhibition of the α-amylase enzyme, which is crucial for carbohydrate breakdown into simpler sugars. By preventing this enzymatic action, less carbohydrate is absorbed in the gastrointestinal tract, potentially leading to reduced calorie intake and aiding weight loss efforts. This local action of the extract may also positively influence metabolic indicators, although further study on exact molecular interactions and bioavailability is needed.

Side effects

White kidney bean extract is generally considered safe for consumption, with no severe adverse events reported. However, common side effects that may affect over 5% of users include headache, flatulence, soft stool, and occasional constipation, although these effects do not significantly differ from those experienced by placebo groups. Uncommon side effects are rarely documented. There are no significant drug interactions or known contraindications, although caution is advised for individuals with existing gastrointestinal issues due to the extract's primary action on the digestive system. Safety in specific populations, such as pregnant women or children, remains inadequately researched.

Dosage

Studies have explored various dosing regimens, generally indicating that typical dosages range from 445 mg to 1500 mg daily. For optimal results, the extract is often taken beforehand carbohydrate-rich meals, with lower doses (around 445 mg to 1000 mg daily) being commonly utilized. While no maximum safe dose is established, the intake of doses up to 1500 mg per day has been tolerated without severe side effects. Variations in dosage may affect efficacy, and factors influencing absorption lean towards its local activity in the gastrointestinal tract rather than systemic bioavailability.

FAQs

How should I take white kidney bean extract?

It is typically taken before meals that are rich in carbohydrates to maximize its effects on α-amylase inhibition.

What are the common side effects?

Common side effects include headaches, flatulence, soft stools, and constipation, although these are similar to placebo effects.

Is white kidney bean extract effective for weight loss?

The efficacy for weight loss is questionable; while some studies show small fat reductions, clinical significance remains uncertain.

Is it safe to use white kidney bean extract?

Yes, it is generally considered safe, with no serious adverse effects reported, though some may experience mild gastrointestinal symptoms.

When should I expect results?

Benefits may surface over short-term periods, typically between 30 days to 12 weeks, but varying results are common.

Research Sources

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.930832/full – This systematic review and meta-analysis assessed the efficacy of white kidney bean extract in weight loss, finding statistical significance in reducing body fat but not overall body weight. Heterogeneity among studies suggests the need for clearer interpretations.