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Lactobacillus Casei R0215

Also known as: Lactobacillus casei R0215, L. casei R0215, Probiotic L. casei

Overview

Lactobacillus casei R0215 is a strain of lactic acid bacteria that is commonly found in fermented foods and the human gut. As a probiotic supplement, it is used to support gastrointestinal health and the immune system. L. casei strains are known for their ability to survive passage through the gastrointestinal tract and adhere to intestinal epithelial cells, allowing them to exert their beneficial effects. Research on L. casei is mature, with numerous studies evaluating its efficacy. The available evidence is generally of high quality, including multiple randomized controlled trials (RCTs) and systematic reviews. It is available in various forms, including capsules, powders, and fermented dairy products.

Benefits

Lactobacillus casei R0215 has demonstrated efficacy in preventing antibiotic-associated diarrhea (AAD). A systematic review and meta-analysis found that L. casei DN-114001 significantly reduced the risk of AAD in adults, with a relative risk (RR) of 0.32 (95% CI 0.16, 0.63), indicating a 68% risk reduction. While a related strain, L. paracasei subsp. paracasei, did not show a significant reduction in the duration of common infectious diseases, this highlights the importance of strain-specific effects. Research on Lactobacillus casei Shirota (a different strain) suggests potential benefits in knee osteoarthritis, but further research is needed to confirm these findings for L. casei R0215. The benefits of L. casei in preventing AAD are observed during antibiotic treatment and may extend beyond.

How it works

Lactobacillus casei R0215 works by modulating the gut microbiota, enhancing the intestinal barrier function, and stimulating the immune system. It interacts with the gastrointestinal tract and the immune system, promoting a healthy gut microbiome. While the exact molecular targets are not fully elucidated, the mechanism involves interactions with intestinal epithelial cells and immune cells. Probiotics like L. casei are generally not absorbed into the bloodstream but exert their effects locally in the gastrointestinal tract.

Side effects

Lactobacillus casei is generally considered safe for consumption. Common side effects, occurring in more than 5% of users, may include mild gastrointestinal symptoms such as bloating, gas, and abdominal discomfort. Uncommon side effects (1-5%) are typically mild and transient, though evidence is limited. Serious adverse effects are rare (less than 1%) and may include infections in immunocompromised individuals. There are no significant known drug interactions, but caution is advised in immunocompromised patients. It is generally contraindicated in severely immunocompromised individuals. Caution is also advised in pregnant or breastfeeding women, although the evidence suggests it is generally safe.

Dosage

The minimum effective dose of Lactobacillus casei R0215 varies by study but typically ranges from 10^9 to 10^10 CFU (Colony-Forming Units) per day. Optimal dosages are often in the range of 10^10 CFU per day. There is no established maximum safe dose, but doses above 10^11 CFU per day are not commonly studied. It is best taken with meals to enhance survival through the stomach. Available in various forms including capsules, powders, and fermented dairy products. Survival through the gastrointestinal tract is enhanced by enteric coating or consumption with food. No specific cofactors are required.

FAQs

Is Lactobacillus casei R0215 safe?

Generally safe, but caution is advised in immunocompromised individuals.

When is the best time to take Lactobacillus casei R0215?

Best taken with meals to enhance survival through the stomach.

What are the expected results of taking Lactobacillus casei R0215?

Benefits may include reduced risk of antibiotic-associated diarrhea and potential improvements in gastrointestinal health.

Are all Lactobacillus casei strains equally effective?

No, not all L. casei strains are equally effective; strain-specific effects are important.

Research Sources

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This systematic review and meta-analysis of 22 RCTs found that Lactobacillus casei DN-114001 significantly reduced the risk of antibiotic-associated diarrhea (AAD) in adults. The pooled data showed a relative risk (RR) of 0.32 (95% CI 0.16, 0.63), indicating a substantial protective effect. The study highlights the importance of strain-specific effects in probiotic interventions.
https://www.mdpi.com/2072-6643/16/14/2243 – This randomized controlled trial (RCT) on 230 participants with knee osteoarthritis found that Lactobacillus casei Shirota showed potential benefits in alleviating symptoms. The study suggests that this specific strain may have a positive impact on osteoarthritis, but further research is needed to confirm these findings for other L. casei strains, including R0215. The research highlights the potential of probiotics in managing osteoarthritis symptoms.
https://www.mdpi.com/2072-6643/12/11/3443 – This systematic review and meta-analysis examined the effects of fermented dairy drinks containing Lactobacillus paracasei subsp. paracasei on common infectious diseases. The study did not find a significant reduction in the duration of these diseases. However, it emphasized the importance of considering strain-specific effects when evaluating the efficacy of probiotics.
https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1095368/full – This network meta-analysis evaluated various probiotic regimens for preventing necrotizing enterocolitis in very low birth weight infants, including combinations with Lactobacillus casei. While Lactobacillus casei was included in some regimens, the specific strain R0215 was not evaluated in this context. The study provides insights into the effectiveness of different probiotic combinations in this vulnerable population.
https://en.wikipedia.org/wiki/index.html?curid=2720799 – Wikipedia provides general information about Lactobacillus casei, including its characteristics, uses, and occurrence in various environments. It serves as a starting point for understanding the basic properties of this lactic acid bacteria. However, it is important to consult peer-reviewed research for detailed and specific information on the R0215 strain.